SEC24_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEC24_SCHPO
• UniProt AC: Q9UUI5
• Protein Name: Protein transport protein sec24
• Gene Name: sec24
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 926
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmi
• Protein Description: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity)..
• Protein Sequence: MSQEDAFYGKGSYGASSGNSNIPPQGFQPVYPVAGQLDNTAPYVGAVAEGTAEGIVSNGEYAVGAMGAAPTNIIGSVDQQPPVSHTSHKSRRQYPAEVFELTNTLAASPAPPSLSEPSYVMARTPSSSPYPHDRAEVGTKSLSAQFGGMSLGADGAAAMPTNELVSVDLYNQTPEISDLTSPPPPINLPLSYSATGAATSNCPPKYVRSTINCVPTTNSLLKKSKIPFALVIRPYTSLVEEDDPVPVVTDTIISRCRRCRMYINPFSIFIDNGHRYRCNSCGIVNEVPQSYDWDSFRNVQRDRWQRPELNYAVVDFIAPQEYMVRAPQPLVYVFLIDISFVSISSGMVGTASRAILESLDRIPNKEGRAKVAFIGVDSALHFFSVSPGAEEATQLVVSDLEEPFLPRNQDLLLNLRECRQGIENLLERFQSMFATTRDSSNALGPGLKAAHRLIENIGGKICCLISSLPNVGVGKLELREDPKLLGTNRESSLLHPNDSFYKSFAVECSTSQVSVDMFLFSSQYQDVATLSCLPRYTSGKTQFYHRWNASRSEDALKFASELTNYLSMEIELEAVMRVRGSNGLRMSSFYGNFFNRSSDLCAFPSFPRDQSYVVEVVIEDTITKPFVSFQTAMLHTTCNGERRIRVLTISLPTTNSMTDLYASADQVAIAQYLTVRASEKALSSTLNEARDSIISKLVEILEVYKKNLAGQNTGAAIPLQISTNLRLLPLLCLALTKHTGFRRSSHISSDLRSIALCYLSTLPTPLLMRYIYPTLYSLHDMPIEAGTVTEQGVVLPSALNLTSALLQSFGLYLVDTHIHQFLYIGKDAVPQLLIDAFGVNSLADLKAGRFTMPVIDNPLNVRINAILGKLRSLDKGSTIMPSLYLVRGDGDPQLRSWFFSHFVEDRSENSPSYLQFLQTLKEKVRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQEDAFYG ------CCHHHHCCC	42.13	29996109
124	Phosphorylation	PSYVMARTPSSSPYP CCEEEECCCCCCCCC	20.27	29996109
126	Phosphorylation	YVMARTPSSSPYPHD EEEECCCCCCCCCCC	42.72	28889911
127	Phosphorylation	VMARTPSSSPYPHDR EEECCCCCCCCCCCC	36.21	25720772
128	Phosphorylation	MARTPSSSPYPHDRA EECCCCCCCCCCCCC	32.56	29996109
130	Phosphorylation	RTPSSSPYPHDRAEV CCCCCCCCCCCCCCC	18.36	25720772
587	Phosphorylation	GSNGLRMSSFYGNFF CCCCCCCEEECCCCC	15.74	25720772
588	Phosphorylation	SNGLRMSSFYGNFFN CCCCCCEEECCCCCC	17.10	25720772
597	Phosphorylation	YGNFFNRSSDLCAFP CCCCCCCCCCCCCCC	29.34	25720772
598	Phosphorylation	GNFFNRSSDLCAFPS CCCCCCCCCCCCCCC	31.22	25720772
744	Phosphorylation	KHTGFRRSSHISSDL CCCCCCCCCCCCHHH	23.24	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEC24_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEC24_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEC24_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THI4_SCHPO	thi2	physical	23695164
THI4_SCHPO	thi2	physical	26771498
SC232_SCHPO	sec2302	physical	26771498
SC231_SCHPO	sec231	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.