SCNNB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNNB_RAT
• UniProt AC: P37090
• Protein Name: Amiloride-sensitive sodium channel subunit beta
• Gene Name: Scnn1b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 638
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . Apical membrane of epithelial cells.
• Protein Description: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception..
• Protein Sequence: MPVKKYLLKCLHRLQKGPGYTYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYPLPAGEKYCNNRDFPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRPNAEVYPDQQTLPIPGTPPPNYDSLRLQPLDTMESDSEVEAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	N-linked_Glycosylation	APKSSHTNTTSTLNF CCCCCCCCCCCEEEE	35.62	-
141	N-linked_Glycosylation	TNTTSTLNFTIWNHT CCCCCEEEEEECCCC	31.91	-
613	Phosphorylation	QTLPIPGTPPPNYDS CCCCCCCCCCCCCCC	27.54	11805112
631	Phosphorylation	QPLDTMESDSEVEAI CCCCCCCCCCCCCCC	35.30	18308722
633	Phosphorylation	LDTMESDSEVEAI-- CCCCCCCCCCCCC--	53.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
613	T	Phosphorylation	Kinase	MAPK1	P63086	GPS
613	T	Phosphorylation	Kinase	MAPK3	P21708	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNNB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNNB_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_RAT	Nedd4	physical	8665844

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.