dbPTM

SCN2A_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SCN2A_RAT
UniProt AC	P04775
Protein Name	Sodium channel protein type 2 subunit alpha
Gene Name	Scn2a
Organism	Rattus norvegicus (Rat).
Sequence Length	2005
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient..
Protein Sequence	MARSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAISRFSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRNPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQAGEEEKEDAVRKSASEDSIRKKGFQFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFNFKGRVKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPSRQRAMSMASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHHFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIALGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIVIQRAYRRYLLKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENSTPEKTDVTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MARSVLVPPGP ----CCCCEECCCCC	27.19	25403869
66	Phosphorylation	GKSLPFIYGDIPPEM CCCCCCCCCCCCHHH	14.77	17959797
104	Phosphorylation	GKAISRFSATSALYI CCHHHCEECCCEEHH	29.53	-
106	Phosphorylation	AISRFSATSALYILT HHHCEECCCEEHHHC	17.21	-
107	Phosphorylation	ISRFSATSALYILTP HHCEECCCEEHHHCC	18.92	-
113	Phosphorylation	TSALYILTPFNPIRK CCEEHHHCCCCHHHH	19.10	-
212	N-linked_Glycosylation	TEFVNLGNVSALRTF HHCCCCCCHHHHHHH	27.95	-
285	N-linked_Glycosylation	CLQWPPDNSTFEINI HHCCCCCCCEEEEEE	49.04	-
291	N-linked_Glycosylation	DNSTFEINITSFFNN CCCEEEEEEEEHHCC	25.04	-
297	N-linked_Glycosylation	INITSFFNNSLDWNG EEEEEHHCCCCCCCC	34.86	-
303	N-linked_Glycosylation	FNNSLDWNGTAFNRT HCCCCCCCCCCCCCE	37.29	-
308	N-linked_Glycosylation	DWNGTAFNRTVNMFN CCCCCCCCCEEEECC	35.93	-
340	N-linked_Glycosylation	NDALLCGNSSDAGQC CCEEEECCCCCCCCC	37.03	-
454	Ubiquitination	QQMLEQLKKQQEEAQ HHHHHHHHHHHHHHH	48.51	-
455	Ubiquitination	QMLEQLKKQQEEAQA HHHHHHHHHHHHHHH	66.85	-
468	Phosphorylation	QAAAAAASAESRDFS HHHHHHHHHHHCCCC	28.04	25403869
471	Phosphorylation	AAAASAESRDFSGAG HHHHHHHHCCCCCCC	36.55	25403869
472	Methylation	AAASAESRDFSGAGG HHHHHHHCCCCCCCC	40.26	67036501
484	Phosphorylation	AGGIGVFSESSSVAS CCCEEECCCCHHHHH	33.88	25403869
486	Phosphorylation	GIGVFSESSSVASKL CEEECCCCHHHHHHH	27.07	25403869
487	Phosphorylation	IGVFSESSSVASKLS EEECCCCHHHHHHHC	25.44	25403869
488	Phosphorylation	GVFSESSSVASKLSS EECCCCHHHHHHHCC	30.86	25403869
491	Phosphorylation	SESSSVASKLSSKSE CCCHHHHHHHCCCCH	31.79	28551015
494	Phosphorylation	SSVASKLSSKSEKEL HHHHHHHCCCCHHHH	39.18	22673903
495	Phosphorylation	SVASKLSSKSEKELK HHHHHHCCCCHHHHH	51.11	22673903
526	Phosphorylation	KEDAVRKSASEDSIR HHHHHHHHCCHHHHH	26.85	25403869
528	Phosphorylation	DAVRKSASEDSIRKK HHHHHHCCHHHHHHH	49.37	25403869
531	Phosphorylation	RKSASEDSIRKKGFQ HHHCCHHHHHHHCEE	21.90	25403869
540	Phosphorylation	RKKGFQFSLEGSRLT HHHCEEEEEECCCCE	18.09	22673903
553	Phosphorylation	LTYEKRFSSPHQSLL CEEHHCCCCCCHHHH	47.17	30411139
554	Phosphorylation	TYEKRFSSPHQSLLS EEHHCCCCCCHHHHH	24.56	30411139
558	Phosphorylation	RFSSPHQSLLSIRGS CCCCCCHHHHHHCCC	28.39	30411139
561	Phosphorylation	SPHQSLLSIRGSLFS CCCHHHHHHCCCCCC	18.61	25403869
563	Methylation	HQSLLSIRGSLFSPR CHHHHHHCCCCCCCC	25.85	16185819
568	Phosphorylation	SIRGSLFSPRRNSRA HHCCCCCCCCCCCCC	23.84	30411139
570	Methylation	RGSLFSPRRNSRASL CCCCCCCCCCCCCCH	49.57	58859397
573	Phosphorylation	LFSPRRNSRASLFNF CCCCCCCCCCCHHEE	27.67	9295379
576	Phosphorylation	PRRNSRASLFNFKGR CCCCCCCCHHEECCC	32.17	12359152
589	Phosphorylation	GRVKDIGSENDFADD CCCCCCCCCCCCCCC	33.29	22673903
610	Phosphorylation	DNDSRRDSLFVPHRH CCCCCCCCCCCCCCC	23.15	30411139
623	Phosphorylation	RHGERRPSNVSQASR CCCCCCCCCHHHHHH	48.31	25403869
626	Phosphorylation	ERRPSNVSQASRASR CCCCCCHHHHHHHHC	25.03	30411139
629	Phosphorylation	PSNVSQASRASRGIP CCCHHHHHHHHCCCC	22.27	30411139
632	Phosphorylation	VSQASRASRGIPTLP HHHHHHHHCCCCCCC	29.90	30411139
665	Phosphorylation	GGPSALTSPVGQLLP CCHHHHCCCCHHCCC	20.59	-
686	Phosphorylation	TEIRKRRSSSYHVSM HHHHHHHCCCCCCCH	27.89	25403869
687	Phosphorylation	EIRKRRSSSYHVSMD HHHHHHCCCCCCCHH	32.86	25403869
688	Phosphorylation	IRKRRSSSYHVSMDL HHHHHCCCCCCCHHH	22.09	25403869
689	Phosphorylation	RKRRSSSYHVSMDLL HHHHCCCCCCCHHHH	14.27	25403869
692	Phosphorylation	RSSSYHVSMDLLEDP HCCCCCCCHHHHCCH	8.02	-
706	Phosphorylation	PSRQRAMSMASILTN HHHHHHHHHHHHHHH	15.37	25403869
709	Phosphorylation	QRAMSMASILTNTME HHHHHHHHHHHHHHH	14.97	25403869
712	Phosphorylation	MSMASILTNTMEELE HHHHHHHHHHHHHHH	27.29	25403869
714	Phosphorylation	MASILTNTMEELEES HHHHHHHHHHHHHHH	22.26	28551015
721	Phosphorylation	TMEELEESRQKCPPC HHHHHHHHHHHCCCH	30.54	25403869
730	Phosphorylation	QKCPPCWYKFANMCL HHCCCHHHHHHHCHH	11.71	17959797
1018	Ubiquitination	QKGIDFVKRKIREFI HHCHHHHHHHHHHHH	48.22	-
1034	Ubiquitination	KAFVRKQKALDEIKP HHHHHHHHHHHHCCC	54.69	-
1040	Ubiquitination	QKALDEIKPLEDLNN HHHHHHCCCHHHHCC	41.31	-
1069	Ubiquitination	GKDLNYLKDGNGTTS CCCCCCCCCCCCCCC	53.91	-
1076	Phosphorylation	KDGNGTTSGIGSSVE CCCCCCCCCCCCCEE	28.40	-
1112	Phosphorylation	VPIALGESDFENLNT EEEEECCCHHHCCCH	45.89	19064667
1124	Phosphorylation	LNTEEFSSESDMEES CCHHHCCCHHHHHHH	46.57	19064667
1126	Phosphorylation	TEEFSSESDMEESKE HHHCCCHHHHHHHHH	44.18	19064667
1182	S-palmitoylation	CVRKFKCCQISIEEG HHHHCCEEEEEEECC	4.08	22123950
1368	N-linked_Glycosylation	GKFYHCINYTTGEMF CHHHHHHCCCCCCCE	33.23	-
1382	N-linked_Glycosylation	FDVSVVNNYSECQAL EEEEEECCHHHHHHH	30.05	-
1393	N-linked_Glycosylation	CQALIESNQTARWKN HHHHHHCCCCCCCCC	30.36	-
1429	Phosphorylation	KGWMDIMYAAVDSRN CCHHHHHHHHHHCCC	7.55	-
1497	Phosphorylation	MTEEQKKYYNAMKKL CCHHHHHHHHHHHHH	14.69	17959797
1498	Phosphorylation	TEEQKKYYNAMKKLG CHHHHHHHHHHHHHC	12.81	17959797
1506	Phosphorylation	NAMKKLGSKKPQKPI HHHHHHCCCCCCCCC	48.20	22426212
1893	Phosphorylation	SNPSKVSYEPITTTL CCCCCCCCCCCCHHH	28.81	17959797
1901	Ubiquitination	EPITTTLKRKQEEVS CCCCHHHHHCHHHHH	56.30	-
1930	Phosphorylation	QKVKKVSSIYKKDKG HHHHHHHHHCCCCCC	32.69	20131913
1936	Ubiquitination	SSIYKKDKGKEDEGT HHHCCCCCCCCCCCC	79.39	-
1938	Ubiquitination	IYKKDKGKEDEGTPI HCCCCCCCCCCCCCC	68.67	-
1943	Phosphorylation	KGKEDEGTPIKEDII CCCCCCCCCCCHHHH	21.57	30411139
1946	Ubiquitination	EDEGTPIKEDIITDK CCCCCCCCHHHHHCC	51.00	-
1953	Ubiquitination	KEDIITDKLNENSTP CHHHHHCCCCCCCCC	44.56	-
1958	Phosphorylation	TDKLNENSTPEKTDV HCCCCCCCCCCCCCC	38.88	22673903
1959	Phosphorylation	DKLNENSTPEKTDVT CCCCCCCCCCCCCCC	47.23	22673903
1963	Phosphorylation	ENSTPEKTDVTPSTT CCCCCCCCCCCCCCC	33.76	16641100
1966	Phosphorylation	TPEKTDVTPSTTSPP CCCCCCCCCCCCCCC	17.84	30240740
1968	Phosphorylation	EKTDVTPSTTSPPSY CCCCCCCCCCCCCCC	34.64	30240740
1969	Phosphorylation	KTDVTPSTTSPPSYD CCCCCCCCCCCCCCC	32.28	16641100
1970	Phosphorylation	TDVTPSTTSPPSYDS CCCCCCCCCCCCCCC	43.50	16641100
1971	Phosphorylation	DVTPSTTSPPSYDSV CCCCCCCCCCCCCCC	34.60	30240740
1974	Phosphorylation	PSTTSPPSYDSVTKP CCCCCCCCCCCCCCC	44.98	30240740
1975	Phosphorylation	STTSPPSYDSVTKPE CCCCCCCCCCCCCCH	20.29	16641100
1977	Phosphorylation	TSPPSYDSVTKPEKE CCCCCCCCCCCCHHH	24.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
554	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
554	S	Phosphorylation	Kinase	PKC	-	Uniprot
573	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
573	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
573	S	Phosphorylation	Kinase	PKACA	P00517	PSP
573	S	Phosphorylation	Kinase	PKC	-	Uniprot
573	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
576	S	Phosphorylation	Kinase	PKC	-	Uniprot
576	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
610	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
610	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
610	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
610	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
610	S	Phosphorylation	Kinase	PKACA	P00517	PSP
623	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
623	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
623	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
687	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
687	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
687	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
687	S	Phosphorylation	Kinase	PKACA	P00517	PSP
1112	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1124	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1126	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1506	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
1506	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
1506	S	Phosphorylation	Kinase	PKC	-	Uniprot
1506	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
1966	T	Phosphorylation	Kinase	GSK3B	G1T8E2	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
38	K	Sumoylation	28029095
Sumoylated at Lys-38.
1506	S	Phosphorylation	1658937
Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SCN2A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SCN4B_HUMAN	SCN4B	physical	12930796
NEDD4_MOUSE	Nedd4	physical	15548568

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SCN2A_RAT

Related Literatures of Post-Translational Modification

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