SCN4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCN4B_HUMAN
• UniProt AC: Q8IWT1
• Protein Name: Sodium channel subunit beta-4
• Gene Name: SCN4B
• Organism: Homo sapiens (Human).
• Sequence Length: 228
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom..
• Protein Sequence: MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	N-linked_Glycosylation	ATDIYAVNGTEILLP CCEEEEECCCEEEEE	43.42	UniProtKB CARBOHYD
69	Phosphorylation	EDLHFRWTYNSSDAF CCEEEEEEECCCHHE	14.47	-
70	Phosphorylation	DLHFRWTYNSSDAFK CEEEEEEECCCHHEE	13.19	-
71	N-linked_Glycosylation	LHFRWTYNSSDAFKI EEEEEEECCCHHEEE	27.88	UniProtKB CARBOHYD
72	Phosphorylation	HFRWTYNSSDAFKIL EEEEEECCCHHEEEE	21.12	-
73	Phosphorylation	FRWTYNSSDAFKILI EEEEECCCHHEEEEE	29.35	-
83	Phosphorylation	FKILIEGTVKNEKSD EEEEEEEEECCCCCC	18.60	22210691
92	Acetylation	KNEKSDPKVTLKDDD CCCCCCCCEEECCCC	53.49	20167786
113	N-linked_Glycosylation	STKEKMNNISIVLRD CCHHHHCCEEEEEEC	26.36	UniProtKB CARBOHYD
115	Phosphorylation	KEKMNNISIVLRDLE HHHHCCEEEEEECEE	14.57	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCN4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCN4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCN4B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SCN4B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00720: Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
• OMIM Disease
• 611819: Long QT syndrome 10 (LQT10)
• 611819: Atrial fibrillation, familial, 17 (ATFB17)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.