SC6A4_HUMAN - dbPTM
SC6A4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SC6A4_HUMAN
UniProt AC P31645
Protein Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Organism Homo sapiens (Human).
Sequence Length 630
Subcellular Localization Cell membrane
Multi-pass membrane protein . Endomembrane system
Multi-pass membrane protein . Endosome membrane
Multi-pass membrane protein . Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecu
Protein Description Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner..
Protein Sequence METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationLNSQKQLSACEDGED
CCCHHHHHCCCCCCC		28.51-
40PhosphorylationTPGDKVESGQISNGY
CCCCCCCCCCCCCCC		38.7028270605
44PhosphorylationKVESGQISNGYSAVP
CCCCCCCCCCCCCCC		19.1328270605
47PhosphorylationSGQISNGYSAVPSPG
CCCCCCCCCCCCCCC		9.5628270605
48PhosphorylationGQISNGYSAVPSPGA
CCCCCCCCCCCCCCC		24.9628270605
52PhosphorylationNGYSAVPSPGAGDDT
CCCCCCCCCCCCCCC		29.3928270605
59PhosphorylationSPGAGDDTRHSIPAT
CCCCCCCCCCCCCCC		34.7128270605
62PhosphorylationAGDDTRHSIPATTTT
CCCCCCCCCCCCCHH		27.2928060719
66PhosphorylationTRHSIPATTTTLVAE
CCCCCCCCCHHHEEH		21.2228270605
67PhosphorylationRHSIPATTTTLVAEL
CCCCCCCCHHHEEHH		21.6428270605
68PhosphorylationHSIPATTTTLVAELH
CCCCCCCHHHEEHHC		17.4928270605
69PhosphorylationSIPATTTTLVAELHQ
CCCCCCHHHEEHHCC		19.6928270605
81PhosphorylationLHQGERETWGKKVDF
HCCCCHHCHHHHHHH		45.8220118234
91PhosphorylationKKVDFLLSVIGYAVD
HHHHHHHHHHCCCCC		17.5229457462
142PhosphorylationMELALGQYHRNGCIS
HHHHHCCHHHCCHHH		10.8421992875
149PhosphorylationYHRNGCISIWRKICP
HHHCCHHHHHHHHHH		21.8524719451
208N-linked_GlycosylationKNSWNTGNCTNYFSE
CCCCCCCCCCCCCCC		27.6627049939
217N-linked_GlycosylationTNYFSEDNITWTLHS
CCCCCCCCEEEEEEC		29.5427049939
276PhosphorylationSIWKGVKTSGKVVWV
HHHCCCCCCCCEEEE		40.0616112691
277PhosphorylationIWKGVKTSGKVVWVT
HHCCCCCCCCEEEEE		30.79-
559PhosphorylationIICSFLMSPPQLRLF
HHHHHHCCCCHHHHH		35.2623186163
603PhosphorylationRLIITPGTFKERIIK
HCCCCCCCHHHHHHH		32.51-
611PhosphorylationFKERIIKSITPETPT
HHHHHHHHCCCCCCC		22.6819270731
613PhosphorylationERIIKSITPETPTEI
HHHHHHCCCCCCCCC		23.3519270731
616PhosphorylationIKSITPETPTEIPCG
HHHCCCCCCCCCCCC		36.3919270731
618PhosphorylationSITPETPTEIPCGDI
HCCCCCCCCCCCCCC		54.7024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
13SPhosphorylationKinaseCAMK2AQ9UQM7
PSP
47YPhosphorylationKinaseSRCP12931
PSP
142YPhosphorylationKinaseSRCP12931
PSP
149SPhosphorylationKinasePRKCAP17252
GPS
276TPhosphorylationKinasePRKG1Q13976
GPS
276TPhosphorylationKinasePKG-Uniprot
277SPhosphorylationKinasePRKCAP17252
GPS
603TPhosphorylationKinasePRKCAP17252
GPS
616TPhosphorylationKinaseMAPK1P28482
GPS
616TPhosphorylationKinaseMAPK3P27361
GPS
616TPhosphorylationKinaseMAPK9P45984
GPS
616TPhosphorylationKinaseMAPK14Q16539
GPS
-KUbiquitinationE3 ubiquitin ligaseSTUB1Q9UNE7
PMID:22199232
-KUbiquitinationE3 ubiquitin ligaseSYVN1Q86TM6
PMID:22199232
-KUbiquitinationE3 ubiquitin ligaseTRIM11Q96F44
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
276TPhosphorylation

17913921
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SC6A4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CALX_HUMANCANXphysical
10364189
CALR_HUMANCALRphysical
10364189
SYUA_HUMANSNCAphysical
16882008
HSP7C_HUMANHSPA8physical
25202009
HS90B_HUMANHSP90AB1physical
25202009
STIP1_HUMANSTIP1physical
25202009
CHIP_HUMANSTUB1physical
25202009
TEBP_HUMANPTGES3physical
25202009
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00110 Cocaine (USP); Cocaine (TN)
D00228 Amoxapine (JP16/USP/INN); Asendin (TN)
D00326 Fluoxetine (USAN/INN); Fluoxetine (TN)
D00367 Mazindol (JAN/USP/INN); Sanorex (TN)
D00394 Trimipramine (USAN/INN)
D00809 Amitriptyline hydrochloride (JP16/USP); Elavil (TN)
D00811 Clomipramine hydrochloride (JP16/USP); Anafranil (TN)
D00812 Desipramine hydrochloride (JAN/USP); Norpramin (TN)
D00815 Imipramine hydrochloride (JP16/USP); Tofranil (TN)
D00816 Nortriptyline hydrochloride (JP16/USP/INN); Pamelor (TN)
D00820 Trazodone hydrochloride (JAN/USP); Desyrel (TN)
D00821 Venlafaxine hydrochloride (JAN/USAN); Effexor (TN)
D00822 Citalopram hydrobromide (USAN); Celexa (TN)
D00823 Fluoxetine hydrochloride (JAN/USP); Prozac (TN)
D00824 Fluvoxamine maleate (JP16/USAN); Luvox (TN)
D00825 Sertraline hydrochloride (JAN/USAN); Zoloft (TN)
D01107 Milnacipran hydrochloride (JAN/USAN); Savella (TN); Toledomin (TN)
D01179 Duloxetine hydrochloride (JAN/USAN); Cymbalta (TN)
D01285 Lofepramine hydrochloride (JAN/USAN); Amplit (TN)
D01546 Dosulepin hydrochloride (JAN); Dothiepin hydrochloride (USAN); Dosulepin (TN)
D02074 Amphetamine sulfate (USP); Benzedrine (TN)
D02078 Dextroamphetamine sulfate (USP); Dexedrine (TN); Dextrostat (TN)
D02182 Cocaine hydrochloride (JP16/USP); Cocaine hydrochloride (TN)
D02242 Methamphetamine hydrochloride (JP16/USP); Desoxyn (TN)
D02260 Paroxetine hydrochloride hydrate (JAN); Paxil (TN)
D02360 Sertraline (INN)
D02362 Paroxetine (USP/INN); Paroxetine (TN)
D02408 Trimipramine maleate (JAN/USAN); Surmontil (TN)
D02567 Escitalopram oxalate (JAN/USAN); Lexapro (TN)
D02570 Desvenlafaxine succinate hydrate (JAN); Desvenlafaxine succinate (USAN); Pristiq (TN)
D02571 Sibutramine hydrochloride hydrate (JAN); Sibutramine hydrochloride (USAN); Sibutramine hydrochloride
D02572 Viloxazine hydrochloride (USAN); Vivalan (TN)
D03110 Bicifadine hydrochloride (USAN)
D03649 Dapoxetine hydrochloride (USAN)
D03713 Dexfenfluramine hydrochloride (USAN); d-Fenfluramine hydrochloride; Redux (TN)
D03740 Dextroamphetamine (USAN); Dexamfetamine (INN)
D05374 Paroxetine hydrochloride (USP); Paxil (TN)
D05375 Paroxetine mesylate (USAN); Brisdelle (TN); Pexeva (TN)
D07334 Imipraminoxide (INN)
D07445 Amfetamine (INN); Amphetamine; Amfetamin (TN)
D07448 Amitriptyline (INN); Laroxyl (TN)
D07449 Amitriptylinoxide (INN)
D07704 Citalopram (USP/INN); Citadur (TN)
D07705 Citalopram hydrochloride; Seropram (TN)
D07727 Clomipramine (INN); Anafranil (TN)
D07791 Desipramine (INN)
D07793 Desvenlafaxine (INN)
D07805 Dexfenfluramine (INN)
D07872 Dosulepin (INN); Dothiepin; Dothep (TN)
D07880 Duloxetine (INN); Yentreve (TN)
D07913 Escitalopram (INN); Esertia (TN)
D07984 Fluvoxamine (INN)
D08070 Imipramine (INN); Tofranil (TN)
D08071 Imipramine embonate; Tofranil-pm (TN)
D08140 Lofepramine (INN)
D08187 Metamfetamine (INN); Methamphetamine
D08222 Milnacipran (INN)
D08288 Nortriptyline (INN); Nortrilen (TN)
D08513 Sibutramine (INN); Butramin (TN)
D08626 Trazodone (INN); Trittico (TN)
D08670 Venlafaxine (INN); Efectin (TN)
D08673 Viloxazine (INN)
D09698 Vilazodone (USAN/INN)
D09699 Vilazodone hydrochloride (USAN); Viibryd (TN)
D10072 Levomilnacipran (USAN/INN)
D10088 Amitifadine (USAN)
D10089 Amitifadine hydrochloride (USAN)
D10133 Levomilnacipran hydrochloride (USAN)
D10443 Liafensine (USAN)
DrugBank
DB00321Amitriptyline
DB00543Amoxapine
DB00182Amphetamine
DB00289Atomoxetine
DB09016Butriptyline
DB01114Chlorphenamine
DB00215Citalopram
DB01242Clomipramine
DB00907Cocaine
DB01151Desipramine
DB06700Desvenlafaxine
DB01191Dexfenfluramine
DB06701Dexmethylphenidate
DB00514Dextromethorphan
DB00988Dopamine
DB01142Doxepin
DB00476Duloxetine
DB01363Ephedra
DB01175Escitalopram
DB00472Fluoxetine
DB00176Fluvoxamine
DB00458Imipramine
DB08918Levomilnacipran
DB00408Loxapine
DB00579Mazindol
DB01577Methamphetamine
DB00422Methylphenidate
DB06148Mianserin
DB04896Milnacipran
DB00805Minaprine
DB00370Mirtazapine
DB01149Nefazodone
DB00540Nortriptyline
DB00715Paroxetine
DB00454Pethidine
DB00191Phentermine
DB00344Protriptyline
DB00852Pseudoephedrine
DB01104Sertraline
DB01105Sibutramine
DB06204Tapentadol
DB00193Tramadol
DB00656Trazodone
DB00726Trimipramine
DB00285Venlafaxine
DB00661Verapamil
DB06684Vilazodone
Regulatory Network of SC6A4_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The cellular distribution of serotonin transporter is impeded onserotonin-altered vimentin network.";
Ahmed B.A., Bukhari I.A., Jeffus B.C., Harney J.T., Thyparambil S.,Ziu E., Fraer M., Rusch N.J., Zimniak P., Lupashin V., Tang D.,Kilic F.;
PLoS ONE 4:E4730-E4730(2009).
Cited for: FUNCTION, INTERACTION WITH VIM, SUBCELLULAR LOCATION, INDUCTION BYSEROTONIN, MUTAGENESIS OF SER-611; THR-613 AND THR-616, ANDPHOSPHORYLATION AT SER-611; THR-613 AND THR-616.
"Tyrosine phosphorylation of the human serotonin transporter: a rolein the transporter stability and function.";
Annamalai B., Mannangatti P., Arapulisamy O., Shippenberg T.S.,Jayanthi L.D., Ramamoorthy S.;
Mol. Pharmacol. 81:73-85(2012).
Cited for: PHOSPHORYLATION AT TYR-47 AND TYR-142.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory