dbPTM

SAHH2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAHH2_ARATH
UniProt AC	Q9LK36
Protein Name	Adenosylhomocysteinase 2
Gene Name	SAHH2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	485
Subcellular Localization
Protein Description	Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine..
Protein Sequence	MALLVEKTSSGREYKVKDMSQADFGRLEIELAEVEMPGLVSCVTEFGPSQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDATLLIHEGVKAEEIFAKNGTFPDPTSTDNPEFQIVLSIIKDGLQVDPKKYHKMKERLVGVSEETTTGVKRLYQMQETGALLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKVAVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGLQVLTLEDVVSEADIFCTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRWVFPDTNSGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKYEKKVYVLPKHLDEKVAALHLGKLGARLTKLTKDQSDYVSIPVEGPYKPVHYRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	KTSSGREYKVKDMSQ ECCCCCEEEEEECHH	21.52	23776212
15	Ubiquitination	TSSGREYKVKDMSQA CCCCCEEEEEECHHH	37.75	17272265
20	Phosphorylation	EYKVKDMSQADFGRL EEEEEECHHHHCCCE	32.14	23776212
113	Phosphorylation	VFAWKGETLQEYWWC EEEECCCCHHHEEEE	42.27	24299221
203	Phosphorylation	KERLVGVSEETTTGV HHHHCCCCHHHCHHH	24.64	24299221
219	Phosphorylation	RLYQMQETGALLFPA HHHHHHHHCCEEEEE	15.74	19376835
236	Phosphorylation	VNDSVTKSKFDNLYG CCCCCCHHHCCCCCC	29.23	24299221
332	Sulfoxidation	TGNKDIIMVDHMRKM CCCCCEEECCCHHHC	2.71	25693801
336	Sulfoxidation	DIIMVDHMRKMKNNA CEEECCCHHHCCCCE	3.69	25693801
370	Phosphorylation	YPGVKRITIKPQTDR CCCEEEEEECCCCCC	27.29	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAHH2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAHH2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAHH2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SAHH1_ARATH	MEE58	physical	25293756

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAHH2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-219, AND MASSSPECTROMETRY.	19376835 [Abstract]
Ubiquitylation
Reference	PubMed
"Multidimensional protein identification technology (MudPIT) analysisof ubiquitinated proteins in plants."; Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.; Mol. Cell. Proteomics 6:601-610(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-15, AND MASSSPECTROMETRY.	17272265 [Abstract]