S26A8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S26A8_HUMAN
• UniProt AC: Q96RN1
• Protein Name: Testis anion transporter 1
• Gene Name: SLC26A8 {ECO:0000312|EMBL:AAK95666.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 970
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Located at the annulus ring structure within the sperm cell.
• Protein Description: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation..
• Protein Sequence: MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	QLERSAISGFSSKSR HHHHHHHCCCCCCHH	33.24	29038488
13	Phosphorylation	RSAISGFSSKSRRNS HHHHCCCCCCHHCCC	40.14	29038488
14	Phosphorylation	SAISGFSSKSRRNSF HHHCCCCCCHHCCCC	32.18	29038488
20	Phosphorylation	SSKSRRNSFAYDVKR CCCHHCCCCHHHHHH	14.94	30622161
30	Phosphorylation	YDVKREVYNEETFQQ HHHHHHHHCHHHHHH	16.47	24114839
34	Phosphorylation	REVYNEETFQQEHKR HHHHCHHHHHHHHHH	22.14	24114839
44	Phosphorylation	QEHKRKASSSGNMNI HHHHHHHHCCCCCCE	28.24	25693802
45	Phosphorylation	EHKRKASSSGNMNIN HHHHHHHCCCCCCEE	47.31	25693802
46	Phosphorylation	HKRKASSSGNMNINI HHHHHHCCCCCCEEE	31.52	25693802
192	N-linked_Glycosylation	PSYLMGYNKSLSVVA CHHHCCCCCCHHHHH	23.01	UniProtKB CARBOHYD
404	Phosphorylation	GLCNVVSSFFRSCVF HHHHHHHHHHHHHHH	19.45	24719451
478	Phosphorylation	ETISNLPSLWRQDQY HHHHCCCHHHHHCCH	43.67	24719451
596	Phosphorylation	EIFSLFNSSDTNLQG HHHHHHCCCCCCCCC	23.43	25693802
597	Phosphorylation	IFSLFNSSDTNLQGG HHHHHCCCCCCCCCC	49.94	25693802
599	Phosphorylation	SLFNSSDTNLQGGKI HHHCCCCCCCCCCEE	39.51	25693802
677	Phosphorylation	QKNQGQQYEEVEEVW CCCCCCCEEEEEEEE	13.23	25693802
693	Phosphorylation	PNNSSRNSSPGLPDV CCCCCCCCCCCCCCH	36.48	30622161
694	Phosphorylation	NNSSRNSSPGLPDVA CCCCCCCCCCCCCHH	26.91	30622161
703	Phosphorylation	GLPDVAESQGRRSLI CCCCHHHHCCCCCCC	28.35	25850435
803	Phosphorylation	LSRKVIGSSELSIDE HHCCHHCCCCCCCCC	14.98	30622161
804	Phosphorylation	SRKVIGSSELSIDES HCCHHCCCCCCCCCC	37.03	30622161
807	Phosphorylation	VIGSSELSIDESETV HHCCCCCCCCCCHHC	24.76	30622161
811	Phosphorylation	SELSIDESETVIRET CCCCCCCCHHCHHHH	34.52	30622161
813	Phosphorylation	LSIDESETVIRETYS CCCCCCHHCHHHHCC	30.43	25693802
818	Phosphorylation	SETVIRETYSETDKN CHHCHHHHCCCCCCC	23.62	29052541
819	Phosphorylation	ETVIRETYSETDKND HHCHHHHCCCCCCCC	10.35	29052541
820	Phosphorylation	TVIRETYSETDKNDN HCHHHHCCCCCCCCC	41.25	29052541
822	Phosphorylation	IRETYSETDKNDNSR HHHHCCCCCCCCCCC	46.46	29052541
833	Phosphorylation	DNSRYKMSSSFLGSQ CCCCEEECHHHHCCC	20.76	-
839	Phosphorylation	MSSSFLGSQKNVSPG ECHHHHCCCCCCCCC	39.88	-
935	Phosphorylation	YWPMYHPSMASTQSQ CCCCCCHHHCCCCCC	17.42	25693802
938	Phosphorylation	MYHPSMASTQSQTQT CCCHHHCCCCCCCCC	20.52	25693802
939	Phosphorylation	YHPSMASTQSQTQTR CCHHHCCCCCCCCCC	23.77	25693802
941	Phosphorylation	PSMASTQSQTQTRTW HHHCCCCCCCCCCCE	34.97	25693802
943	Phosphorylation	MASTQSQTQTRTWSV HCCCCCCCCCCCEEE	36.84	25693802
945	Phosphorylation	STQSQTQTRTWSVER CCCCCCCCCCEEEEC	33.19	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S26A8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S26A8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S26A8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NXF1_HUMAN	NXF1	physical	7707528

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 606766: Spermatogenic failure 3 (SPGF3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.