RPGFL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPGFL_HUMAN
• UniProt AC: Q9UHV5
• Protein Name: Rap guanine nucleotide exchange factor-like 1
• Gene Name: RAPGEFL1
• Organism: Homo sapiens (Human).
• Sequence Length: 662
• Protein Description: Probable guanine nucleotide exchange factor (GEF)..
• Protein Sequence: MKPLEKFLKKQTSQLAGRTVAGGPGGGLGSCGGPGGGGGPGGGGGPAGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEPPVPEEGGEPAGVAEEPGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLNRVLERLAGGATRDSAASDILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Ubiquitination	SVSRLLLPAFLREPP HHHHHHHHHHHCCCC	22.42	-
96	Phosphorylation	AGVAEEPGSGGPCWL CCCCCCCCCCCCCEE	42.05	27251275
107	Phosphorylation	PCWLQLEEVPGPGPL CCEEEEEECCCCCCC	63.71	27251275
151	Phosphorylation	PLGAPERPEHLLNRV CCCCCCCHHHHHHHH	31.53	-
162	Phosphorylation	LNRVLERLAGGATRD HHHHHHHHCCCCCCC	3.66	-
181	Phosphorylation	DILLDDIVLTHSLFL HHHHHHHHHHCCCCC	6.93	-
302	Phosphorylation	RHFRRIDSCLQTRVA HHHHHHHHHHHHCEE	17.85	26657352
313	Phosphorylation	TRVAFRGSDEIFCRV HCEEEECCCEEEEEE	28.01	25849741
332	Phosphorylation	HSYVTIRSRLSASVQ CCEEEEHHHHHHHHH	33.45	24706070
335	Phosphorylation	VTIRSRLSASVQDIL EEEHHHHHHHHHHHH	19.86	24706070
337	Phosphorylation	IRSRLSASVQDILGS EHHHHHHHHHHHHHH	19.55	29083192
344	Phosphorylation	SVQDILGSVTEKLQY HHHHHHHHHHHHHHC	23.56	29083192
346	Phosphorylation	QDILGSVTEKLQYSE HHHHHHHHHHHHCCC	29.15	24706070
369	O-linked_Glycosylation	LILVAVSSSGEKVLL EEEEEECCCCCEEEE	35.45	29351928
370	O-linked_Glycosylation	ILVAVSSSGEKVLLQ EEEEECCCCCEEEEC	43.39	29351928
462	Phosphorylation	GERGRRETANLELLL CCCCCHHHCCHHHHH	21.02	-
528	Phosphorylation	GLDNAAVSRLRLTWE CCCHHHHHHHHCCHH	22.37	-
566	Phosphorylation	KSYREVISKMKPPVI HHHHHHHHHCCCCCC	31.69	-
567	Acetylation	SYREVISKMKPPVIP HHHHHHHHCCCCCCC	39.56	18586879

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPGFL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPGFL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPGFL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.