RPA49_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPA49_MOUSE
• UniProt AC: Q8K202
• Protein Name: DNA-directed RNA polymerase I subunit RPA49
• Gene Name: Polr1e
• Organism: Mus musculus (Mouse).
• Sequence Length: 482
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF..
• Protein Sequence: MATLESPGMDDQAGDTETEALQSARWLYCGEPDDRQKAVLVQFSNGKLQNPGDMRFTLYNSTDLVNPRQRSHRIVAAETDRLSYVGNNFGTGALKCNALCRHFVGILNKTSGQMEVYDAELFNMQPLFAGMGTEVIKLGGQHLYLLAFCQPSKNLAEAGDLLLSRHRQGHCIAVLLDDDAIEREPPLENQNKTFRDKLDSCIEAFGSTKQKRSLNSRRMNKVGSESLNLSVAKAAESIIDTKGVNALVSDAMQDDLQDGVLYLPPCYADAAKPEDVYRFEDILSPAEYDALESPSEAFRKVTSEDILKMIEENSHCSYVIEMLKSLPIDEVHRNRQARSIWFLDALIRFRAQKVIKGKRALGPGIPHIINTKLLKQFTCLTYNNGRLQNLISSSMRAKITSYAIILALHINNFQVDLTALQKDLKLSEKRMIEIAKAMRLKISKQKVSLADGREESHRLGTLSVPLPPAQNSDRQSKRRKMN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATLESPGMD -----CCCCCCCCCC	29.75	25619855
6	Phosphorylation	--MATLESPGMDDQA --CCCCCCCCCCCCC	29.84	27566939
16	Phosphorylation	MDDQAGDTETEALQS CCCCCCCCHHHHHHH	43.84	25619855
200	Phosphorylation	TFRDKLDSCIEAFGS HHHHHHHHHHHHHCC	27.68	28066266
224	Phosphorylation	RRMNKVGSESLNLSV HHCCHHCHHHHCHHH	27.31	30482847
226	Phosphorylation	MNKVGSESLNLSVAK CCHHCHHHHCHHHHH	25.01	29514104
230	Phosphorylation	GSESLNLSVAKAAES CHHHHCHHHHHHHHH	20.96	28066266
436	Acetylation	KRMIEIAKAMRLKIS HHHHHHHHHHCHHCC	48.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPA49_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
436	K	Acetylation	Acetylated at Lys-436 by CREBBP/CBP, leading to decreased RNA polymerase I transcription.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPA49_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPA2_MOUSE	Polr1b	physical	16582105
RRN3_HUMAN	RRN3	physical	12393749

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.