RPA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPA2_MOUSE
• UniProt AC: P70700
• Protein Name: DNA-directed RNA polymerase I subunit RPA2
• Gene Name: Polr1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1135
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)..
• Protein Sequence: MDVDGRWRNLPSGPSLKHLTDPSYGIPPEQQKAALQDLTRAHVDSFNYAALEGLSHAVQAIPPFEFAFKDERISLTIVDAVISPPSVPKGTICKDLNVYPAECRGRKSTYRGRLTADISWAVNGVPKGIIKQFLGYVPIMVKSKLCNLYNLPPRVLIEHHEEAEEMGGYFIINGIEKVIRMLIVPRRNFPIAMVRPKWKSRGLGYTQFGVSMRCVREEHSAVNMNLHYVENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEEDSFFRNSVSQMLRIVIEEGCHSQKQVLNYLGECFRVKLSLPDWYPNVEAAEFLLNQCICIHLQSNTDKFYLLCLMTRKLFALARGECMDDNPDSLVNQEVLSPGQLFLMFLKEKMENWLVSIKIVLDKRAQKANVSINNENLMKIFSMGTELTRPFEYLLATGNLRSKTGLGFLQDSGLCVVADKLNFLRYLSHFRCVHRGAAFAKMRTTTVRRLLPESWGFLCPVHTPDGAPCGLLNHLTAVCEVVTKFVYTASIPALLCGLGVTPVDTAPCRPYSDCYPVLLDGVMVGWVDKDLAPEVADTLRRFKVLREKRIPPWMEVALIPMTGKPSLYPGLFLFTTPCRLVRPVQNLELGREELIGTMEQLFMNVAIFEDEVFGGISTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQNRSDNKLYRLQTPQSPLVRPCMYDFYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKFKQGEDNLVFGVKPGDPRVMQKLDDDGLPFIGAKLEYGDPYYSYLNLNTGEGFVVYYKSKENCVVDNIKVCSNDMGSGKFKCICITVRIPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMMPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGMELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPLGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHMCVECGSLLSPLLEKPPPSWSAMRNRKYNCTVCGRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	TIVDAVISPPSVPKG EEEEEECCCCCCCCC	24.94	26745281
86	Phosphorylation	DAVISPPSVPKGTIC EEECCCCCCCCCCEE	55.20	26745281
459	Ubiquitination	GLCVVADKLNFLRYL CEEEEECHHHHHHHH	35.28	27667366
607	Phosphorylation	MTGKPSLYPGLFLFT CCCCCCCCCCEEEEE	10.29	-
693	Ubiquitination	MYQCQMGKQTMGFPL EEECCCCCCCCCCCE	36.93	22790023
784	Ubiquitination	EFIDLSEKFKQGEDN HEECHHHHHHCCCCC	55.26	22790023
844	Ubiquitination	FVVYYKSKENCVVDN EEEEEECCCCEEEEE	49.12	-
882	Ubiquitination	RNPTIGDKFASRHGQ CCCCCHHHHHHHHCC	37.30	22790023
966	Ubiquitination	LEYFGEMLKAAGYNF HHHHHHHHHHCCCCE	2.73	27667366
1020	Ubiquitination	RTTGARDKVTNQPLG ECCCCCCCCCCCCCC	45.46	27667366
1051	Phosphorylation	ALLAHGTSFLLHDRL HHHHCCCHHHHCCHH	20.63	-
1118	Phosphorylation	SVPYVFRYFVAELAA CHHHHHHHHHHHHHH	7.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMEB2_MOUSE	Gmeb2	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.