RP9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RP9_HUMAN
• UniProt AC: Q8TA86
• Protein Name: Retinitis pigmentosa 9 protein
• Gene Name: RP9
• Organism: Homo sapiens (Human).
• Sequence Length: 221
• Subcellular Localization: Nucleus.
• Protein Description: Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity)..
• Protein Sequence: MSSRPGREDVGAAGARRPREPPEQELQRRREQKRRRHDAQQLQQLKHLESFYEKPPPGLIKEDETKPEDCIPDVPGNEHAREFLAHAPTKGLWMPLGKEVKVMQCWRCKRYGHRTGDKECPFFIKGNQKLEQFRVAHEDPMYDIIRDNKRHEKDVRIQQLKQLLEDSTSDEDRSSSSSSEGKEKHKKKKKKEKHKKRKKEKKKKKKRKHKSSKSNEGSDSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	QQLKHLESFYEKPPP HHHHHHHHHHHCCCC	39.22	28796482
52	Phosphorylation	LKHLESFYEKPPPGL HHHHHHHHHCCCCCC	32.11	28796482
54	Ubiquitination	HLESFYEKPPPGLIK HHHHHHHCCCCCCCC	51.98	-
54	Acetylation	HLESFYEKPPPGLIK HHHHHHHCCCCCCCC	51.98	26051181
118	Acetylation	YGHRTGDKECPFFIK CCCCCCCCCCCEEEE	63.66	23954790
129	Ubiquitination	FFIKGNQKLEQFRVA EEEECCHHHHEEEEC	58.97	-
129	Acetylation	FFIKGNQKLEQFRVA EEEECCHHHHEEEEC	58.97	25953088
129	Sumoylation	FFIKGNQKLEQFRVA EEEECCHHHHEEEEC	58.97	28112733
142	Phosphorylation	VAHEDPMYDIIRDNK ECCCCCHHHHHHCCC	14.91	25884760
212	Phosphorylation	KKRKHKSSKSNEGSD HHHHHHCCCCCCCCC	44.93	-
214	Phosphorylation	RKHKSSKSNEGSDSE HHHHCCCCCCCCCCC	41.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
212	S	Phosphorylation	Kinase	PIM1	P11309	Uniprot
214	S	Phosphorylation	Kinase	PIM1	P11309	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RP9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RP9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AF1_HUMAN	U2AF1	physical	15474994
A4_HUMAN	APP	physical	21832049
CIR1_HUMAN	CIR1	physical	15652350

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 180104: Retinitis pigmentosa 9 (RP9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.