ROS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ROS1_HUMAN
• UniProt AC: P08922
• Protein Name: Proto-oncogene tyrosine-protein kinase ROS
• Gene Name: ROS1
• Organism: Homo sapiens (Human).
• Sequence Length: 2347
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2..
• Protein Sequence: MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	N-linked_Glycosylation	LDLGTPHNLSEPCIQ CCCCCCCCCCCCCCC	46.60	UniProtKB CARBOHYD
114	N-linked_Glycosylation	ASSIGSHNMTLRWKS HHHCCCCCEEEEEEE	27.17	UniProtKB CARBOHYD
123	N-linked_Glycosylation	TLRWKSANFSGVKYI EEEEEECCCCCCCEE	38.41	UniProtKB CARBOHYD
135	Phosphorylation	KYIIQWKYAQLLGSW CEEEEEEHHHHHCCE	9.16	-
143	Phosphorylation	AQLLGSWTYTKTVSR HHHHCCEEEEEEECC	24.02	-
144	Phosphorylation	QLLGSWTYTKTVSRP HHHCCEEEEEEECCC	10.44	-
145	Phosphorylation	LLGSWTYTKTVSRPS HHCCEEEEEEECCCC	16.92	-
188	Phosphorylation	PPSPSYRTHPHGVPE CCCCCCCCCCCCCCC	31.37	-
196	Phosphorylation	HPHGVPETAPLIRNI CCCCCCCCCHHEECC	27.75	-
299	Phosphorylation	WLFLSRKTSLRKRSL HHHHCCHHHHHHHHH	31.70	22468782
305	Phosphorylation	KTSLRKRSLKHLVDE HHHHHHHHHHHHHHH	44.82	22468782
324	N-linked_Glycosylation	RLDAIYHNITGISVD HHHHHHHCCCCEEEE	19.28	UniProtKB CARBOHYD
352	N-linked_Glycosylation	IWAKKAANMSDVSDL EEEEECCCCCCCCCE	35.04	UniProtKB CARBOHYD
366	Phosphorylation	LRIFYRGSGLISSIS EEEEECCCCHHHEEE	22.79	27273156
373	Phosphorylation	SGLISSISIDWLYQR CCHHHEEEHHHHHHH	19.22	27273156
378	Phosphorylation	SISIDWLYQRMYFIM EEEHHHHHHHHHHHH	6.99	27273156
396	N-linked_Glycosylation	VCVCDLENCSNIEEI EEEEECCCCCCCCCC	41.64	UniProtKB CARBOHYD
469	Phosphorylation	PQAKRIIYFNDTAQV CCCEEEEEECCHHHH	8.24	24043423
471	N-linked_Glycosylation	AKRIIYFNDTAQVFM CEEEEEECCHHHHHH	28.84	UniProtKB CARBOHYD
473	Phosphorylation	RIIYFNDTAQVFMST EEEEECCHHHHHHHH	21.79	24043423
479	Phosphorylation	DTAQVFMSTFLDGSA CHHHHHHHHHCCCCC	12.44	24043423
480	Phosphorylation	TAQVFMSTFLDGSAS HHHHHHHHHCCCCCH	19.21	24043423
485	Phosphorylation	MSTFLDGSASHLILP HHHHCCCCCHHCCCC	26.68	24043423
487	Phosphorylation	TFLDGSASHLILPRI HHCCCCCHHCCCCCC	22.11	24043423
501	Phosphorylation	IPFADVKSFACENND CCCCCCEEEEECCCC	20.23	23663014
607	N-linked_Glycosylation	LGPSAWQNWTYEVKV HCCCHHCCCEEEEEE	23.50	UniProtKB CARBOHYD
628	N-linked_Glycosylation	EVTHIFLNISGTMLN CCEEEEEECCCCCCC	18.68	UniProtKB CARBOHYD
645	Phosphorylation	ELQSAMKYKVSVRAS HHHHHHEEEEEEEEC	11.97	22210691
652	Phosphorylation	YKVSVRASSPKRPGP EEEEEEECCCCCCCC	36.29	22210691
653	Phosphorylation	KVSVRASSPKRPGPW EEEEEECCCCCCCCC	33.19	22210691
688	Phosphorylation	VKEDGLWSKPLNSFG ECCCCCCCCCCCCCC	29.45	24719451
706	N-linked_Glycosylation	FLSSDIGNVSDMDWY CCCCCCCCCCCCCCC	30.38	UniProtKB CARBOHYD
714	N-linked_Glycosylation	VSDMDWYNNSLYYSD CCCCCCCCCCEEEEC	27.62	UniProtKB CARBOHYD
732	N-linked_Glycosylation	DVFVWLLNGTDISEN CEEEEEECCCCCCCC	49.50	UniProtKB CARBOHYD
773	Phosphorylation	TYVIQRQSVLTGHTD EEEEEECHHHCCCCH	22.68	24043423
776	Phosphorylation	IQRQSVLTGHTDIVT EEECHHHCCCCHHHH	25.43	24043423
779	Phosphorylation	QSVLTGHTDIVTHVK CHHHCCCCHHHHHHH	28.85	24043423
783	Phosphorylation	TGHTDIVTHVKLLVN CCCCHHHHHHHHHHC	22.68	24043423
800	Phosphorylation	VVDSVGGYLYWTTLY EECCCCCEEEEEEEE	7.24	-
802	Phosphorylation	DSVGGYLYWTTLYSV CCCCCEEEEEEEEEE	7.69	-
807	Phosphorylation	YLYWTTLYSVESTRL EEEEEEEEEEEEEEC	14.47	-
818	Phosphorylation	STRLNGESSLVLQTQ EEECCCCCEEEEEEC	30.30	-
939	N-linked_Glycosylation	SLKPLPGNFSFTPKV ECCCCCCCCCCCCCC	27.70	UniProtKB CARBOHYD
961	N-linked_Glycosylation	SSFRIEGNASSFQIL CCEEEECCCCCEEEE	24.69	UniProtKB CARBOHYD
1015	N-linked_Glycosylation	LEPYALFNLSVTPYT CCCEEEEEEEEECCC	32.05	UniProtKB CARBOHYD
1031	Phosphorylation	WGKGPKTSLSLRAPE CCCCCCCEEEEECCC	23.30	17081983
1033	Phosphorylation	KGPKTSLSLRAPETV CCCCCEEEEECCCCC	18.64	17081983
1054	Phosphorylation	PRIFILPSGKCCNKN CCEEEECCCCCCCCC	47.65	24719451
1087	N-linked_Glycosylation	TKFEIFYNISNQSIT EEEEEEEEECCCCCC	22.06	UniProtKB CARBOHYD
1090	N-linked_Glycosylation	EIFYNISNQSITNKT EEEEEECCCCCCCCC	35.50	UniProtKB CARBOHYD
1095	N-linked_Glycosylation	ISNQSITNKTCEDWI ECCCCCCCCCCCCEE	35.65	UniProtKB CARBOHYD
1147	Phosphorylation	ADVVKSTTSEINPFP HHHEECCCCCCCCCC	31.30	27174698
1148	Phosphorylation	DVVKSTTSEINPFPH HHEECCCCCCCCCCH	36.25	27174698
1158	Phosphorylation	NPFPHLITLLGNKIV CCCCHHHHHHCCEEE	23.45	27174698
1185	Phosphorylation	FSAERVISAVCYTAD EEHHHEEEEEEEECC	16.28	-
1190	Phosphorylation	VISAVCYTADNEMGY EEEEEEEECCCCCEE	23.55	-
1211	N-linked_Glycosylation	LFLLHLHNRSSSELF EEEEEECCCCCCHHH	52.46	UniProtKB CARBOHYD
1259	Acetylation	FDVDLEHKVKYPREV EEEECCCCCCCCCEE	30.92	24246823
1272	N-linked_Glycosylation	EVKIHNRNSTIISFS EEEEECCCCCEEEEE	49.15	UniProtKB CARBOHYD
1273	Phosphorylation	VKIHNRNSTIISFSV EEEECCCCCEEEEEH	20.11	-
1274	Phosphorylation	KIHNRNSTIISFSVY EEECCCCCEEEEEHH	26.36	-
1330	N-linked_Glycosylation	KRNQCSCNVTEFELS HCCCCCCCEEEEEEE	27.70	UniProtKB CARBOHYD
1375	Phosphorylation	CQCWRVITVPAMLAG CCCEEEEEHHHHHCC	19.99	-
1458	N-linked_Glycosylation	TVEPTILNATNTSLT CCCCEEECCCCCEEE	40.65	UniProtKB CARBOHYD
1461	N-linked_Glycosylation	PTILNATNTSLTIRL CEEECCCCCEEEEEE	25.84	UniProtKB CARBOHYD
1474	N-linked_Glycosylation	RLPLAKTNLTWYGIT EEEEECCCCEEEECC	34.46	UniProtKB CARBOHYD
1499	N-linked_Glycosylation	AEVNDRKNSSDLKYR EEECCCCCCCCCCHH	47.87	UniProtKB CARBOHYD
1504	Acetylation	RKNSSDLKYRILEFQ CCCCCCCCHHHHEEH	37.16	19817273
1535	Phosphorylation	IQIAVKNYYSDPLEH EEHHHHHHCCCCHHH	9.91	22817900
1565	N-linked_Glycosylation	PEAVQLINTTVRSDT CHHHHHHHEECCCCC	37.99	UniProtKB CARBOHYD
1570	O-linked_Glycosylation	LINTTVRSDTSLIIS HHHEECCCCCEEEEE	40.69	29237092
1577	O-linked_Glycosylation	SDTSLIISWRESHKP CCCEEEEEEHHHCCC	17.06	29237092
1577	Phosphorylation	SDTSLIISWRESHKP CCCEEEEEEHHHCCC	17.06	24719451
1581	O-linked_Glycosylation	LIISWRESHKPNGPK EEEEEHHHCCCCCCH	28.39	29237092
1606	Phosphorylation	HLALIPETPLRQSEF HHHCCCCCCCCCCCC	23.44	24719451
1669	N-linked_Glycosylation	PYSLVPENTSLQFNW CCCCCCCCCCEEEEC	28.97	UniProtKB CARBOHYD
1715	N-linked_Glycosylation	QGPAYVCNITNLQPY CCCEEEEECCCCCCC	33.79	UniProtKB CARBOHYD
1738	N-linked_Glycosylation	VVYKTGENSTSLPES EEEECCCCCCCCCHH	52.51	UniProtKB CARBOHYD
1749	Acetylation	LPESFKTKAGVPNKP CCHHHCCCCCCCCCC	43.67	18527139
1782	Phosphorylation	EDNGCRITYYILEIR HHCCCEEEEEEEEEH	7.30	25003641
1783	Phosphorylation	DNGCRITYYILEIRK HCCCEEEEEEEEEHH	6.02	25003641
1784	Phosphorylation	NGCRITYYILEIRKS CCCEEEEEEEEEHHH	7.15	25003641
1791	Phosphorylation	YILEIRKSTSNNLQN EEEEEHHHCCCCCCC	27.50	27174698
1792	Phosphorylation	ILEIRKSTSNNLQNQ EEEEHHHCCCCCCCC	38.21	27174698
1793	Phosphorylation	LEIRKSTSNNLQNQN EEEHHHCCCCCCCCC	30.71	27174698
1808	N-linked_Glycosylation	LRWKMTFNGSCSSVC CEEEEEECCCCCCEE	32.10	UniProtKB CARBOHYD
1812	Phosphorylation	MTFNGSCSSVCTWKS EEECCCCCCEEEEEC	27.74	23879269
1813	Phosphorylation	TFNGSCSSVCTWKSK EECCCCCCEEEEECC	26.07	23879269
1819	Phosphorylation	SSVCTWKSKNLKGIF CCEEEEECCCCCCEE	20.52	30631047
1923	Phosphorylation	VGLANACYAIHTLPT HHHHHHHHHHHCCCC	13.23	22817900
1927	Phosphorylation	NACYAIHTLPTQEEI HHHHHHHCCCCHHHH	28.46	-
1930	Phosphorylation	YAIHTLPTQEEIENL HHHHCCCCHHHHHCC	52.29	19060867
1944	Acetylation	LPAFPREKLTLRLLL CCCCCHHHHHHHHHH	48.31	19828873
1981	Phosphorylation	EIKVAVKTLKKGSTD EEEEEEEEHHCCCCC	36.89	28509920
1986	Phosphorylation	VKTLKKGSTDQEKIE EEEHHCCCCCHHHHH	37.38	28509920
1987	Phosphorylation	KTLKKGSTDQEKIEF EEHHCCCCCHHHHHH	50.82	28509920
2002	Phosphorylation	LKEAHLMSKFNHPNI HHHHHHHHHCCCHHH	40.22	-
2023	Phosphorylation	CLLNEPQYIILELME CHHCCCCEEEEEECC	10.72	24043423
2036	Phosphorylation	MEGGDLLTYLRKARM CCCCCHHHHHHHHHH	28.01	24043423
2037	Phosphorylation	EGGDLLTYLRKARMA CCCCHHHHHHHHHHH	12.41	24043423
2045	Phosphorylation	LRKARMATFYGPLLT HHHHHHHHHHHHHHH	14.19	26074081
2047	Phosphorylation	KARMATFYGPLLTLV HHHHHHHHHHHHHHH	17.30	26074081
2069	Phosphorylation	DISKGCVYLERMHFI HHHCCCHHHHHHHHH	13.61	-
2110	Phosphorylation	FGLARDIYKNDYYRK CCCCCHHHCCCHHHH	14.18	21253578
2114	Phosphorylation	RDIYKNDYYRKRGEG CHHHCCCHHHHCCCC	17.98	21253578
2115	Phosphorylation	DIYKNDYYRKRGEGL HHHCCCHHHHCCCCC	16.72	21253578
2173	Phosphorylation	SNLDVLNYVQTGGRL CCCCCHHCCCCCCCC	6.97	-
2227	Phosphorylation	NFFLNSIYKSRDEAN HHHHHHHHCCCCCHH	11.61	27642862
2255	Phosphorylation	GDVICLNSDDIMPVA CCEEEECCCCCEEEE	24.58	23917254
2266	Phosphorylation	MPVALMETKNREGLN EEEEEEECCCCCCCC	21.47	23917254
2274	Phosphorylation	KNREGLNYMVLATEC CCCCCCCEEEEEEEC	8.14	12538861
2323	Phosphorylation	CQEKQVAYCPSGKPE HHHHCEEECCCCCCC	13.16	22817900
2326	Phosphorylation	KQVAYCPSGKPEGLN HCEEECCCCCCCCCC	56.75	-
2334	Phosphorylation	GKPEGLNYACLTHSG CCCCCCCEEEECCCC	12.06	12538861
2338	Phosphorylation	GLNYACLTHSGYGDG CCCEEEECCCCCCCC	17.55	-
2340	Phosphorylation	NYACLTHSGYGDGSD CEEEECCCCCCCCCC	28.60	21082442
2342	Phosphorylation	ACLTHSGYGDGSD-- EEECCCCCCCCCC--	18.30	18083107
2346	Phosphorylation	HSGYGDGSD------ CCCCCCCCC------	44.90	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ROS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ROS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ROS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN6_HUMAN	PTPN6	physical	11266449
PTN11_HUMAN	PTPN11	physical	11266449
VAV3_HUMAN	VAV3	physical	11094073
GRB2_HUMAN	GRB2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• H00014: Non-small cell lung cancer
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.