ROBO1_MOUSE - dbPTM
ROBO1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ROBO1_MOUSE
UniProt AC O89026
Protein Name Roundabout homolog 1
Gene Name Robo1
Organism Mus musculus (Mouse).
Sequence Length 1612
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Cell projection, axon . Detected at growth cones in thalamus neurons (PubMed:24560577).
Protein Description Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. [PubMed: 10433822]
Protein Sequence MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTLILSCVATGSPAPTILWRKDGVLVSTQDSRIKQLESGVLQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSKNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTAAENVKTETFAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTSQGVDHKQVQRELGNVVLHLHNPTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPRSVTVSKNDGNGTAILVTWQPPPEDTQNGMVQEYKVWCLGNETKYHINKTVDGSTFSVVIPSLVPGIRYSVEVAASTGAGPGVKSEPQFIQLDSHGNPVSPEDQVSLAQQISDVVRQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPATQPWLADTWPNTGNNHNDCSINCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQANLSNNMNNGAGDSSEKHWKPPGQQKPEVAPIQYNIMEQNKLNKDYRANDTIPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKAPKQGGMNWADLLPPPPAHPPPHSNSEEYNMSVDESYDQEMPCPVPPAPMYLQQDELQEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAVVIQKARPAKKQKHQPGHLRREAYADDLPPPPVPPPAIKSPTVQSKAQLEVRPVMVPKLASIEARTDRSSDRKGGSYKGREALDGRQVTDLRTNPSDPREAQEQPNDGKGRGTRQPKRDLPPAKTHLGQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNMAEMQVLGGFERGDENNEELEETES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
121N-linked_GlycosylationLGEAVSHNASLEVAI
CCHHHHCCCEEEEEE		24.58-
424N-linked_GlycosylationVIRQGPVNQTVAVDG
CCCCCCCCCEEEECC		34.63-
751N-linked_GlycosylationTVSKNDGNGTAILVT
EEEECCCCCEEEEEE		47.72-
781N-linked_GlycosylationYKVWCLGNETKYHIN
EEEEECCCCEEEEEE		40.59-
788N-linked_GlycosylationNETKYHINKTVDGST
CCEEEEEEECCCCCE		22.19-
809PhosphorylationSLVPGIRYSVEVAAS
CCCCCCCEEEEEHHH		18.3629899451
898UbiquitinationSTYAGIRKVPSFTFT
CCCCCCCCCCEEEEC		57.48-
901PhosphorylationAGIRKVPSFTFTPTV
CCCCCCCEEEECCEE		39.6525521595
903PhosphorylationIRKVPSFTFTPTVTY
CCCCCEEEECCEEEE		30.8226643407
905PhosphorylationKVPSFTFTPTVTYQR
CCCEEEECCEEEEEE		18.2626643407
907PhosphorylationPSFTFTPTVTYQRGG
CEEEECCEEEEEECC		23.5629472430
909PhosphorylationFTFTPTVTYQRGGEA
EEECCEEEEEECCEE		19.20-
999PhosphorylationMLPESTVYGDVDLSN
CCCCCCEECCCCCHH		14.01-
1013PhosphorylationNKINEMKTFNSPNLK
HHHHCCCCCCCCCCC		27.0928059163
1016PhosphorylationNEMKTFNSPNLKDGR
HCCCCCCCCCCCCCC		15.8029472430
1034PhosphorylationPSGQPTPYATTQLIQ
CCCCCCCCHHHHHHH		21.04-
1075PhosphorylationPEVAPIQYNIMEQNK
CCCCCCCCCHHHHCC		13.84-
1114PhosphorylationTGGSYNSSDRGSSTS
CCCCCCCCCCCCCCC		27.91-
1201PhosphorylationEEDERGPTPPVRGAA
HHHHCCCCCCCCCCC		42.94-
1258PhosphorylationDRRRQPVSPPPPPRP
CCCCCCCCCCCCCCC		38.07-
1396PhosphorylationGRRHFHASQCPRPTS
HCCCCCHHHCCCCCC		24.6023984901
1402PhosphorylationASQCPRPTSPVSTDS
HHHCCCCCCCCCCCC		47.1223984901
1403PhosphorylationSQCPRPTSPVSTDSN
HHCCCCCCCCCCCCC		26.4529472430
1406PhosphorylationPRPTSPVSTDSNMSA
CCCCCCCCCCCCCEE		29.8523984901
1407PhosphorylationRPTSPVSTDSNMSAV
CCCCCCCCCCCCEEE		43.6223984901
1409PhosphorylationTSPVSTDSNMSAVVI
CCCCCCCCCCEEEEE		34.2223984901
1412PhosphorylationVSTDSNMSAVVIQKA
CCCCCCCEEEEEECC		23.3523984901
1453PhosphorylationVPPPAIKSPTVQSKA
CCCCCCCCCCCCCCC		21.4923984901
1455PhosphorylationPPAIKSPTVQSKAQL
CCCCCCCCCCCCCEE		37.9623984901
1458PhosphorylationIKSPTVQSKAQLEVR
CCCCCCCCCCEEEEC		26.1423984901
1489PhosphorylationSSDRKGGSYKGREAL
CCCCCCCCCCCCCCC		32.1320139300
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ROBO1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ROBO1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ROBO1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRGP1_MOUSESrgap1physical
11672528
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ROBO1_MOUSE

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Related Literatures of Post-Translational Modification

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