RNB3L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNB3L_HUMAN
• UniProt AC: Q86VV4
• Protein Name: Ran-binding protein 3-like
• Gene Name: RANBP3L
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner..
• Protein Sequence: MTTIPRKGSSHLPGSLHTCKLKLQEDRRQQEKSVIAQPIFVFEKGEQTFKRPAEDTLYEAAEPECNGFPTKRVRSSSFTFHITDSQSQGVRKNNVFMTSALVQSSVDIKSAEQGPVKHSKHVIRPAILQLPQARSCAKVRKTFGHKALESCKTKEKTNNKISEGNSYLLSENLSRARISVQLSTNQDFLGATSVGCQPNEDKCSFKSCSSNFVFGENMVERVLGTQKLTQPQLENDSYAKEKPFKSIPKFPVNFLSSRTDSIKNTSLIESAAAFSSQPSRKCLLEKIDVITGEETEHNVLKINCKLFIFNKTTQSWIERGRGTLRLNDTASTDCGTLQSRLIMRNQGSLRLILNSKLWAQMKIQRANHKNVRITATDLEDYSIKIFLIQASAQDTAYLYAAIHHRLVALQSFNKQRDVNQAESLSETAQQLNCESCDENEDDFIQVTKNGSDPSSWTHRQSVACS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTTIPRKGS ------CCCCCCCCC	33.17	27486199
3	Phosphorylation	-----MTTIPRKGSS -----CCCCCCCCCC	27.90	27486199
76	Phosphorylation	PTKRVRSSSFTFHIT CCCCCCCCEEEEEEE	20.93	-
77	Phosphorylation	TKRVRSSSFTFHITD CCCCCCCEEEEEEEC	29.56	-
83	Phosphorylation	SSFTFHITDSQSQGV CEEEEEEECCCCCCC	22.49	-
98	Phosphorylation	RKNNVFMTSALVQSS CCCCEEECCCCEEEC	10.20	25690035
104	Phosphorylation	MTSALVQSSVDIKSA ECCCCEEECCCCCCC	25.50	28555341
110	Phosphorylation	QSSVDIKSAEQGPVK EECCCCCCCCCCCCC	37.05	30576142
119	Phosphorylation	EQGPVKHSKHVIRPA CCCCCCCCCCCCHHH	20.81	28555341
150	Phosphorylation	FGHKALESCKTKEKT HCHHHHHHHCCCCHH	23.05	26074081
153	Phosphorylation	KALESCKTKEKTNNK HHHHHHCCCCHHCCC	49.08	20886841
265	Phosphorylation	RTDSIKNTSLIESAA CCCCCCCCHHHHHHH	21.65	22210691
266	Phosphorylation	TDSIKNTSLIESAAA CCCCCCCHHHHHHHH	36.42	-
279	Phosphorylation	AAFSSQPSRKCLLEK HHHCCCCCHHHHHHE	36.41	22210691
291	Phosphorylation	LEKIDVITGEETEHN HHEECEECCCCCCCC	38.09	-
315	Phosphorylation	IFNKTTQSWIERGRG EEECCHHHHHHCCCC	28.12	23927012
382	Phosphorylation	ATDLEDYSIKIFLIQ EECHHHCEEEEEEEE	29.72	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNB3L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNB3L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNB3L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPRTN_HUMAN	SPRTN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.