RN220_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN220_MOUSE
• UniProt AC: Q6PDX6
• Protein Name: E3 ubiquitin-protein ligase Rnf220
• Gene Name: Rnf220
• Organism: Mus musculus (Mouse).
• Sequence Length: 566
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. [PubMed: 20170641 Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity]
• Protein Sequence: MDLHRAAFKMENSSYLPNPLASPALMVLASTAEASRDASIPCQQPRPFGVPVSVDKDVHIPFTNGSYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSGVGAFRPFASTEDRESYQSAFTPAKRLKNCHDTESPHLRFSDADGKEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLISDRETSSSPEDRNDRCKKKAVALFDSQAPLCPICQVLLRPSELQEHMEQELEQLAQLPASKNSLLKDAMAPGTPKSLLLSASIKREGDSPTASPHSSATEDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQREGSCMAEDDAVDIEHADSNRFEEYEWCGQKRIRATTLLEGGFRGSGFVMCSGKENPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPEFSKWASDEMPSTSNGEGSKQEAMQKTCKNSDIEKITEESAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKLCPQCNTITAPGDLRRIYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
173	Phosphorylation	GTQLPSSSPGSLKVD CCCCCCCCCCCEEEC	37.30	29899451
256	Phosphorylation	QLPASKNSLLKDAMA CCCHHCCHHHHHHCC	38.52	28059163
362	Ubiquitination	EYEWCGQKRIRATTL CCCCCCCCCCEEEEE	34.77	-
390	Phosphorylation	SGKENPDSDADLDVD CCCCCCCCCCCCCCC	35.64	21082442
401	Phosphorylation	LDVDGDDTLEYGKPQ CCCCCCCCCCCCCCC	26.65	25293948
404	Phosphorylation	DGDDTLEYGKPQYTE CCCCCCCCCCCCCCC	33.30	26643407
409	Phosphorylation	LEYGKPQYTEADVIP CCCCCCCCCCCCEEE	18.31	26643407
410	Phosphorylation	EYGKPQYTEADVIPC CCCCCCCCCCCEEEC	21.32	26643407
451	Acetylation	RITPEFSKWASDEMP CCCHHHHHHCCCCCC	52.69	7718573
451	Ubiquitination	RITPEFSKWASDEMP CCCHHHHHHCCCCCC	52.69	-
466	Phosphorylation	STSNGEGSKQEAMQK CCCCCCCHHHHHHHH	27.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Rnf220	Q6PDX6	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN220_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN220_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3B_MOUSE	Sin3b	physical	20170641

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.