RN141_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN141_HUMAN
• UniProt AC: Q8WVD5
• Protein Name: RING finger protein 141
• Gene Name: RNF141
• Organism: Homo sapiens (Human).
• Sequence Length: 230
• Subcellular Localization: Membrane ; Lipid-anchor .
• Protein Description: May be involved in spermatogenesis..
• Protein Sequence: MGQQISDQTQLVINKLPEKVAKHVTLVRESGSLTYEEFLGRVAELNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITSQAAGVLAQSSTSEEPDENSSSVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGQQISDQT ------CCCCCCHHH	28.27	25807930
6	Phosphorylation	--MGQQISDQTQLVI --CCCCCCHHHHHHH	21.23	25690035
30	Phosphorylation	HVTLVRESGSLTYEE HCEEEECCCCCCHHH	24.10	-
32	Phosphorylation	TLVRESGSLTYEEFL EEEECCCCCCHHHHH	27.15	-
34	Phosphorylation	VRESGSLTYEEFLGR EECCCCCCHHHHHHH	30.50	-
35	Phosphorylation	RESGSLTYEEFLGRV ECCCCCCHHHHHHHH	20.82	-
51	Ubiquitination	ELNDVTAKVASGQEK HHHHCEEEECCCCCE	29.03	30230243
82	S-nitrosylation	KVVVRVVCTKINKSS HHHHHHHHCCCCCCC	2.68	24105792
135	Phosphorylation	DENSSSVTSCQASLW CCCCCCHHHHHHHHH	26.23	27251275
136	Phosphorylation	ENSSSVTSCQASLWM CCCCCHHHHHHHHHH	11.32	27251275
140	Phosphorylation	SVTSCQASLWMGRVK CHHHHHHHHHHCCEE	9.18	27251275
147	Ubiquitination	SLWMGRVKQLTDEEE HHHHCCEEECCCCCC	37.92	29901268
174	S-nitrosylation	LPCAHSFCQKCIDKW HHCHHHHHHHHHHHH	4.19	24105792
176	Ubiquitination	CAHSFCQKCIDKWSD CHHHHHHHHHHHHHH	34.05	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN141_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN141_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN141_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DTX3_HUMAN	DTX3	physical	22493164
TRIM8_HUMAN	TRIM8	physical	22493164

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.