RMLCD_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RMLCD_ARATH
• UniProt AC: Q9LQ04
• Protein Name: Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase {ECO:0000305}
• Gene Name: NRS/ER {ECO:0000303|PubMed:15020741}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 301
• Protein Description: Bifunctional enzyme involved in dTDP-beta-L-rhamnose biosynthesis. Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-4-keto-alpha-D-glucose to form dTDP-4-keto-beta-L-rhamnose and its reduction to yield dTDP-beta-L-rhamnose. Can form UDP-beta-L-rhamnose from UDP-6-deoxy-4-keto-alpha-D-glucose, but cannot convert GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose..
• Protein Sequence: MVADANGSSSSSFNFLIYGKTGWIGGLLGKLCEAQGITYTYGSGRLQDRQSIVADIESVKPSHVFNAAGVTGRPNVDWCESHKVETIRTNVAGTLTLADICREKGLVLINYATGCIFEYDSGHPLGSGIGFKEEDTPNFTGSFYSKTKAMVEELLKNYENVCTLRVRMPISSDLTNPRNFITKIARYEKVVDIPNSMTILDELLPISIEMAKRNLTGIYNFTNPGVVSHNEILEMYRDYIDPSFTWKNFTLEEQAKVIVAPRSNNELDATKLKTEFPELMSIKESLIKFVFEPNKKTEVKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
216	Phosphorylation	EMAKRNLTGIYNFTN HHHHCCCCCCCCCCC		22074104
222	Phosphorylation	LTGIYNFTNPGVVSH CCCCCCCCCCCCCCH		22074104
228	Phosphorylation	FTNPGVVSHNEILEM CCCCCCCCHHHHHHH		22074104
280	Sulfoxidation	KTEFPELMSIKESLI CCCCHHHHCHHHHHH		25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RMLCD_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RMLCD_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RMLCD_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHM1_ARATH	RHM1	physical	21798944
RMLCD_ARATH	NRS/ER	physical	26116145

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.