RIC1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIC1_DROME
• UniProt AC: Q9V3C5
• Protein Name: Guanine nucleotide exchange factor subunit Rich {ECO:0000305}
• Gene Name: Rich
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1429
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein . Colocalizes with Rab6 at the Golgi apparatus.
• Protein Description: Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses..
• Protein Sequence: MYYPVGWPKRVGLALPGESASIRHICCDAVKILVAAVGDDFLGIWYANPLIPIAYFRRTEDSLRQYGANQLIVWKPDSRQLALLTASGSLLLYQLDFEANGMGILQQIDPPAASLKRDSAELFIKENIPRLSLRELCSVTLGSVITTVCCISLSELLLATQSCELLRLQWTELEHAENDLELPALSSIKLRDIPFYVQQQPQQSARNVPPLNRDSYVASLEYSPFIGGCAAVFSDRRAAFLIANHLRFETDHMHGFWVPDVEDASVCSVNHKFRLLAYGQESSAVKVYAIDDATGGLEFSHRLILTENILPDSLGSVNELKWSPDGCVLAVSWTNGGLSLWSTFGALLMSTLSWDFGLNVDLVCQNPLKIRRLEWSTEGYQLFMLKLHPEKDKSNVLQLQFVKSALSMNPCMTTSPHILLQGDDCLYLNQGNNLELTYAGSHGTFPSSGLGSDEDISGDGDCLELKQSPHTGSILTESKYWTVLQLPLNYAATNWPIRYAAIDPDGLHLAVAGRTGLAHYSLVTRRWKLFGNESQEKDFVVSGGLLWWHGFVVMGCYSLLDRTDELRCYPADCKLDNQYGHKLQVRAPVISLNSFRHQLIVLTADGIVSLFNMSKNSAYALDIECAYELDVKSICIHPACIVSLTVTNLKNELKPQGQLGGDQAETIIVNVCGRILMIQRDAGEQVPNTLLATCLASCVEVFWLSHSLERCAMRDCLWLYSGAHGMRVWLPILPPGRERREGEQGGAQRLHSFMSKRIMLSFPLKLYPLVVLFDNVIVLGVENESTLYANEQVSHFSLPFAVMERKSQIYLHKVLRQLIKRNLGYSAWEMAQSCCSLPYFPHALELLLHEVLEEEATSKQPIPDAQLPSILDFIREFPVYLETIVQCARKTEIALWPYLFSMAGKPKDLFQMCLQSEQLDTAASYLIILQNLEPSVVSKQYATMLLDIALQQRKWELAKDLIRFLKAIDPNEIDSPRSSMVVNVKIAPPPQVNTQQQVNQNADAFNMVLGPIARERSFSTTVTSNLPKDKQASGTPGVAPVTESSSAGAPSVVRRRSTKQRETFCIDLILQRHARQLLQNHKLMDLGYMCAYLDFHLVSWLSQESERAAKLDDFAGALQALHEELDLPIPFPTAAKDDFAQIRGSLRQTGGGGSSQTSESGYFSLATPNGAATQSPQLQPSIREEEEELQQPSSLPILKTRSGSQLSFDNFRYRRLYSLPTSEDDLAVDILPQKLSIKLRYLLQLFIEANCTDYALVLSILLQDAASISRIVNGIIRSESVHTCRRTESALKQLSQSTFEHSGSLYRGFVLTLQPHVYLLEQYIQSLGDAPCSQLQDAGPGTEQGVDVSTGLQGLQNEVGEFVPNSQQANGNQWTVADLNPNHQRLTRHASLESNGNAVVASGSSAHSTPTQRQLSRQNSREREGCRLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
223	Phosphorylation	YVASLEYSPFIGGCA CEEEEEECCCCCCHH	12.17	22817900
234	Phosphorylation	GGCAAVFSDRRAAFL CCHHEEECHHHHHHH	24.49	22817900
975	Phosphorylation	IDPNEIDSPRSSMVV CCCCCCCCCCCCEEE	28.07	19429919
1019	Phosphorylation	IARERSFSTTVTSNL HHHHCCCEEEECCCC	25.15	21082442
1200	Phosphorylation	SSLPILKTRSGSQLS CCCCCEECCCCCCCE	26.99	19429919
1202	Phosphorylation	LPILKTRSGSQLSFD CCCEECCCCCCCEEC	48.29	19429919
1204	Phosphorylation	ILKTRSGSQLSFDNF CEECCCCCCCEECCC	29.24	19429919
1207	Phosphorylation	TRSGSQLSFDNFRYR CCCCCCCEECCCEEE	23.94	19429919
1217	Phosphorylation	NFRYRRLYSLPTSED CCEEEEECCCCCCCC	13.32	19429919
1218	Phosphorylation	FRYRRLYSLPTSEDD CEEEEECCCCCCCCH	32.25	19429919
1221	Phosphorylation	RRLYSLPTSEDDLAV EEECCCCCCCCHHHH	50.47	19429919
1222	Phosphorylation	RLYSLPTSEDDLAVD EECCCCCCCCHHHHH	36.77	19429919
1391	Phosphorylation	QRLTRHASLESNGNA CHHHCCEEEECCCCE	26.92	19429919
1394	Phosphorylation	TRHASLESNGNAVVA HCCEEEECCCCEEEE	56.16	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIC1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIC1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIC1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB6_DROME	Rab6	genetic	21835342
CADN_DROME	CadN	genetic	21835342

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1207; SER-1391 ANDSER-1394, AND MASS SPECTROMETRY.
PubMed: 18327897