RHG27_HUMAN - dbPTM
RHG27_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHG27_HUMAN
UniProt AC Q6ZUM4
Protein Name Rho GTPase-activating protein 27
Gene Name ARHGAP27
Organism Homo sapiens (Human).
Sequence Length 889
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein.
Protein Description Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity)..
Protein Sequence MAADVVGDVYVLVEHPFEYTGKDGRRVAIRPNERYRLLRRSTEHWWHVRREPGGRPFYLPAQYVRELPALGNPAAAAPPGPHPSPAAPEPLAYDYRFVSAAATAGPDGAPEESGGRASSLCGPAQRGAATQRSSLAPGLPACLYLRPAAPVRPAQSLNDLACAAVSPPAGLLGSSGSFKACSVAGSWVCPRPLARSDSENVYEVIQDLHVPPPEESAEQVDDPPEPVYANIERQPRATSPGAAAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWESPFEAAEGAASPATSPASVDSHVSLETEWGQYWDEESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10 (in isoform 4)Phosphorylation-7.8827642862
41PhosphorylationRYRLLRRSTEHWWHV
HHHHHHHHCCCCEEE		31.5423898821
41 (in isoform 4)Phosphorylation-31.5427251275
42PhosphorylationYRLLRRSTEHWWHVR
HHHHHHHCCCCEEEE		30.0228348404
84PhosphorylationAPPGPHPSPAAPEPL
CCCCCCCCCCCCCCC		24.9223312004
84 (in isoform 4)Phosphorylation-24.9224719451
93PhosphorylationAAPEPLAYDYRFVSA
CCCCCCCCCCCCCHH		22.6127259358
93 (in isoform 4)Phosphorylation-22.6127642862
95 (in isoform 4)Phosphorylation-8.0227642862
95PhosphorylationPEPLAYDYRFVSAAA
CCCCCCCCCCCHHHH		8.0223312004
113PhosphorylationPDGAPEESGGRASSL
CCCCCCCCCCCCHHH		44.9024719451
113 (in isoform 4)Phosphorylation-44.9024719451
114 (in isoform 2)Phosphorylation-32.6527251275
118PhosphorylationEESGGRASSLCGPAQ
CCCCCCCHHHCCHHH		23.6028348404
119 (in isoform 4)Phosphorylation-27.0527251275
119PhosphorylationESGGRASSLCGPAQR
CCCCCCHHHCCHHHC		27.0528348404
125 (in isoform 2)Phosphorylation-47.6924719451
130PhosphorylationPAQRGAATQRSSLAP
HHHCCCCHHHHHCCC		24.79-
133PhosphorylationRGAATQRSSLAPGLP
CCCCHHHHHCCCCCC		21.6427251275
134PhosphorylationGAATQRSSLAPGLPA
CCCHHHHHCCCCCCE		30.6427251275
134 (in isoform 4)Phosphorylation-30.6427251275
140 (in isoform 2)Phosphorylation-27.1727251275
144PhosphorylationPGLPACLYLRPAAPV
CCCCEEEEEECCCCC		10.6828348404
144 (in isoform 4)Phosphorylation-10.6827251275
156PhosphorylationAPVRPAQSLNDLACA
CCCCCCCCCCHHHHH		31.1123898821
156 (in isoform 4)Phosphorylation-31.1127251275
166PhosphorylationDLACAAVSPPAGLLG
HHHHHHHCCCCHHCC		22.0523898821
174 (in isoform 4)Phosphorylation-31.3427251275
174PhosphorylationPPAGLLGSSGSFKAC
CCCHHCCCCCCCCCC		31.3428348404
175PhosphorylationPAGLLGSSGSFKACS
CCHHCCCCCCCCCCE		36.3428348404
177PhosphorylationGLLGSSGSFKACSVA
HHCCCCCCCCCCEEC		26.0628348404
182PhosphorylationSGSFKACSVAGSWVC
CCCCCCCEECCCEEC		21.6225849741
182 (in isoform 4)Phosphorylation-21.6224719451
186PhosphorylationKACSVAGSWVCPRPL
CCCEECCCEECCCCC		13.4428102081
196 (in isoform 4)Phosphorylation-39.6227642862
202 (in isoform 4)Phosphorylation-18.9627642862
210 (in isoform 2)Ubiquitination-11.2121890473
216PhosphorylationHVPPPEESAEQVDDP
CCCCCHHHHCCCCCC		35.13-
228PhosphorylationDDPPEPVYANIERQP
CCCCCCCCCCCCCCC		12.4925147952
238PhosphorylationIERQPRATSPGAAAA
CCCCCCCCCCCCCCC		36.4126657352
239PhosphorylationERQPRATSPGAAAAP
CCCCCCCCCCCCCCC		21.9826657352
249PhosphorylationAAAAPLPSPVWETHT
CCCCCCCCCCEEEEC		39.5126657352
254PhosphorylationLPSPVWETHTDAGTG
CCCCCEEEECCCCCC		17.8626074081
256PhosphorylationSPVWETHTDAGTGRP
CCCEEEECCCCCCCC		34.6626074081
260PhosphorylationETHTDAGTGRPYYYN
EEECCCCCCCCCEEC		31.5723312004
291 (in isoform 2)Phosphorylation-22.1524719451
297 (in isoform 2)Phosphorylation-24.5124719451
339 (in isoform 2)Phosphorylation-48.6624719451
347PhosphorylationLEMQPGLSPGSPGDP
HCCCCCCCCCCCCCC		32.88-
358PhosphorylationPGDPRPPTPETDYPE
CCCCCCCCCCCCCCH		36.1226074081
408PhosphorylationSQDKQMLYTNHFTQE
CCCCCEEEECCCCHH		10.5124043423
409PhosphorylationQDKQMLYTNHFTQEQ
CCCCEEEECCCCHHH		20.4624043423
413PhosphorylationMLYTNHFTQEQWVRL
EEEECCCCHHHCEEC		24.5224043423
430PhosphorylationPHGKPYFYNPEDSSV
CCCCCCCCCCCCCCC		24.7823312004
435PhosphorylationYFYNPEDSSVRWELP
CCCCCCCCCCCEECC		29.1323312004
436PhosphorylationFYNPEDSSVRWELPQ
CCCCCCCCCCEECCC		28.2023312004
451PhosphorylationVPVPAPRSIHKSSQD
CCCCCCCCCCCCCCC		28.1723663014
455PhosphorylationAPRSIHKSSQDGDTP
CCCCCCCCCCCCCCC		21.0423401153
456PhosphorylationPRSIHKSSQDGDTPA
CCCCCCCCCCCCCCC		36.7728176443
461PhosphorylationKSSQDGDTPAQASPP
CCCCCCCCCCCCCCC		26.5028176443
466PhosphorylationGDTPAQASPPEEKVP
CCCCCCCCCCHHHCC		28.9823401153
481PhosphorylationAELDEVGSWEEVSPA
CCCCCCCCHHHCCCC		36.1728464451
486PhosphorylationVGSWEEVSPATAAVR
CCCHHHCCCCHHHHH		16.4625159151
499MethylationVRTKTLDKAGVLHRT
HHCCCCCCCCCCCCE		50.59-
524UbiquitinationKKHWSASWTVLEGGV
HHHCCEEEEEEECCE		7.1121890473
524 (in isoform 3)Ubiquitination-7.1121890473
536AcetylationGGVLTFFKDSKTSAA
CCEEEEEECCCCCCC		57.83133715
538PhosphorylationVLTFFKDSKTSAAGG
EEEEEECCCCCCCCC		38.1222210691
550PhosphorylationAGGLRQPSKFSTPEY
CCCCCCCCCCCCCCE		37.6928857561
551UbiquitinationGGLRQPSKFSTPEYT
CCCCCCCCCCCCCEE		50.4421890473
551 (in isoform 1)Ubiquitination-50.4421890473
575PhosphorylationWAPKDKSSRKNVLEL
CCCCCCCCCCCEEEE		53.6821712546
615PhosphorylationAQGIQELSAELPPEE
HHHHHHHHCCCCCCC		20.9528450419
623PhosphorylationAELPPEESESSRVDF
CCCCCCCCCCCCCCC		40.9130576142
625PhosphorylationLPPEESESSRVDFGS
CCCCCCCCCCCCCCC		32.4927251275
626PhosphorylationPPEESESSRVDFGSS
CCCCCCCCCCCCCCC		32.0728450419
632PhosphorylationSSRVDFGSSERLGSW
CCCCCCCCCCCCCCH		29.0823401153
633PhosphorylationSRVDFGSSERLGSWQ
CCCCCCCCCCCCCHH		27.4130278072
638PhosphorylationGSSERLGSWQEKEED
CCCCCCCCHHHHHCC		30.1222617229
666UbiquitinationGLESDLSKVRHKLRK
CCHHHHHHHHHHHHH		51.05-
680PhosphorylationKFLQRRPTLQSLREK
HHHHHCHHHHHHHHC		35.3026657352
683PhosphorylationQRRPTLQSLREKGYI
HHCHHHHHHHHCCCC		32.2923882029
743UbiquitinationGNLATIQKLRYKVDH
CCCHHHHHHCCCCCC		30.95-
786O-linked_GlycosylationPEPLFPFSHFRQFIA
CCCCCCHHHHHHHHH		23.1930379171
821PhosphorylationLPAPNHDTLRMLFQH
CCCCCHHHHHHHHHH		14.55-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHG27_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHG27_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHG27_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAC1_HUMANRAC1physical
15147912
CDC42_HUMANCDC42physical
15147912
SH3K1_HUMANSH3KBP1physical
15147912
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHG27_HUMAN

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Related Literatures of Post-Translational Modification

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