RENBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RENBP_HUMAN
• UniProt AC: P51606
• Protein Name: N-acylglucosamine 2-epimerase
• Gene Name: RENBP
• Organism: Homo sapiens (Human).
• Sequence Length: 427
• Protein Description: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded..
• Protein Sequence: MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYDDLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQLQGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVSEGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHGGLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQFRDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPTPACRGAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Acetylation	PARQDMEKERETLQA CCHHHHHHHHHHHHH	56.27	19822099
22	Acetylation	RETLQAWKERVGQEL HHHHHHHHHHHHHHH	38.36	19822107
244	Ubiquitination	ENVSEGGKELPGCLG HCCCCCCCCCCCCCC	67.92	-
355	Phosphorylation	LFYQVAEYTFRQFRD HHHHHHHHHHHHHCC	11.05	24719451
356	Phosphorylation	FYQVAEYTFRQFRDP HHHHHHHHHHHHCCC	12.12	24719451
377	Acetylation	GYLSREGKVALSIKG EEECCCCEEEEEECC	21.41	11697115
381	Phosphorylation	REGKVALSIKGGPFK CCCEEEEEECCCCCC	16.71	28060719
383	Acetylation	GKVALSIKGGPFKGC CEEEEEECCCCCCCC	55.21	11697125
409	Phosphorylation	EMLGALLSRPAPAPS HHHHHHHCCCCCCCC	36.75	25348772
416	Phosphorylation	SRPAPAPSPAPTPAC CCCCCCCCCCCCCCC	35.48	29255136
420	Phosphorylation	PAPSPAPTPACRGAE CCCCCCCCCCCCCCC	26.14	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RENBP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RENBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RENBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBED1_HUMAN	ZBED1	physical	16189514

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.