RELN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RELN_HUMAN
• UniProt AC: P78509
• Protein Name: Reelin
• Gene Name: RELN
• Organism: Homo sapiens (Human).
• Sequence Length: 3460
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity)..
• Protein Sequence: MERSGWARQTFLLALLLGATLRARAAAGYYPRFSPFFFLCTHHGELEGDGEQGEVLISLHIAGNPTYYVPGQEYHVTISTSTFFDGLLVTGLYTSTSVQASQSIGGSSAFGFGIMSDHQFGNQFMCSVVASHVSHLPTTNLSFIWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLCEQGAPTDVTVHPHLAEIHSDSIILRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYGPRELITTGLNTTTASVLQFSIGSGSCRFSYSDPSIIVLYAKNNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVGEVYEACWALDNILIINSAHRQVVLEDSLDPVDTGNWLFFPGATVKHSCQSDGNSIYFHGNEGSEFNFATTRDVDLSTEDIQEQWSEEFESQPTGWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGGICDPGNSHENDIILYAKIEGRKEHITLDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNMWAIDNVYIGPSCLKFCSGRGQCTRHGCKCDPGFSGPACEMASQTFPMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMTSVLFNSISLDFTNLVEVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDEWALDSIYIGQQCPNMCSGHGSCDHGICRCDQGYQGTECHPEAALPSTIMSDFENQNGWESDWQEVIGGEIVKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESASCNKPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIILSEKQKQIIPVINPTLPQNFYEKPAFDYPMNQMSVWLMLANEGMVKNETFCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPVLLQYSHDAGMSWFLVKEGCYPASAGKGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYISEPCPSYCSGHGDCISGVCFCDLGYTAAQGTCVSNVPNHNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRTRNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIGMNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQLQYSLNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVLASGCPWMCSGRGICDAGRCVCDRGFGGPYCVPVVPLPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPERSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGNNVNNPVMLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCNGQGSCINGTKCICDPGYSGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNISGNTVLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCIDMCSGHGRCIQGNCVCDEQWGGLYCDDPETSLPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPNNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLISGSADQRTVMLDTFSSAPVPQHERSPADAGPVGRIAFDMFMEDKTSVNEHWLFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTEGWIMQFKISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCLDNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEVVLVSTRKQNYMMNFSRQHGLRHFYNRRRRSLRRYP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RSGWARQTFLLALLL CCHHHHHHHHHHHHH	15.65	-
29	Phosphorylation	RARAAAGYYPRFSPF HHHHHCCCCCCCCCE	12.93	-
30	Phosphorylation	ARAAAGYYPRFSPFF HHHHCCCCCCCCCEE	6.24	-
140	N-linked_Glycosylation	VSHLPTTNLSFIWIA HHCCCCCCEEEEEEC	35.84	UniProtKB CARBOHYD
184	O-linked_Glycosylation	LCEQGAPTDVTVHPH HHHCCCCCCCEECHH	42.44	OGP
257	N-linked_Glycosylation	ELITTGLNTTTASVL HHEECCCCCCCCEEE	36.40	UniProtKB CARBOHYD
278	Phosphorylation	GSCRFSYSDPSIIVL CCCEEEECCCEEEEE	41.67	-
281	Phosphorylation	RFSYSDPSIIVLYAK EEEECCCEEEEEEEC	29.91	-
286	Phosphorylation	DPSIIVLYAKNNSAD CCEEEEEEECCCCCC	12.49	-
289	N-linked_Glycosylation	IIVLYAKNNSADWIQ EEEEEECCCCCCCEE	39.25	UniProtKB CARBOHYD
299	Acetylation	ADWIQLEKIRAPSNV CCCEEEEECCCCCCC	46.19	20167786
305	N-linked_Glycosylation	EKIRAPSNVSTIIHI EECCCCCCCCEEEEE	30.60	19159218
308	Phosphorylation	RAPSNVSTIIHILYL CCCCCCCEEEEEEEC	21.48	30622161
314	Phosphorylation	STIIHILYLPEDAKG CEEEEEEECCCCCCC	21.43	30622161
463	Phosphorylation	DGERKLCTPSMDTTG CCCEEEECCCCCCCC	28.91	26552605
465	Phosphorylation	ERKLCTPSMDTTGYG CEEEECCCCCCCCCC	15.90	26552605
468	Phosphorylation	LCTPSMDTTGYGNLR EECCCCCCCCCCCEE	17.30	26552605
469	Phosphorylation	CTPSMDTTGYGNLRF ECCCCCCCCCCCEEE	24.92	26552605
471	Phosphorylation	PSMDTTGYGNLRFYF CCCCCCCCCCEEEEE	10.76	26552605
628	N-linked_Glycosylation	STVYSSENYSGWNRI CCEECCCCCCCCCCE	37.91	UniProtKB CARBOHYD
728	Phosphorylation	SSYHNFYSIRGAEVS CCCCCEEEECCCEEE	11.15	24719451
735	Phosphorylation	SIRGAEVSFGCGVLA EECCCEEEECCEEEE	13.87	-
743	Phosphorylation	FGCGVLASGKALVFN ECCEEEECCCEEEEC	36.34	-
764	Phosphorylation	LITSFLDSSQSRFLQ HHHHHHCCCHHHHHH	32.21	-
773	Phosphorylation	QSRFLQFTLRLGSKS HHHHHHHHEECCCCC	9.67	19664995
779	Ubiquitination	FTLRLGSKSVLSTCR HHEECCCCCHHHCCC	42.67	-
833	Ubiquitination	VELPGDAKQFGIQFR EECCCCHHHHCEEEE	51.40	-
914	Phosphorylation	KLASSMRYVETQSMQ HHHHCCEEEECCCCC	8.26	22210691
917	Phosphorylation	SSMRYVETQSMQIGA HCCEEEECCCCCCCH	18.85	22210691
926	Phosphorylation	SMQIGASYMIQFSLV CCCCCHHHHEEEEEE	9.56	28985074
1054	Phosphorylation	ICRCDQGYQGTECHP CCCCCCCCCCCCCCC	9.72	22210691
1067	Phosphorylation	HPEAALPSTIMSDFE CCCCCCCCCHHHCCC	31.26	22210691
1081	Phosphorylation	ENQNGWESDWQEVIG CCCCCCCCCCEEHHC	37.33	22210691
1221	Phosphorylation	VDDIIILSEKQKQII CCEEEEEEHHHHCEE	32.13	24719451
1266	N-linked_Glycosylation	ANEGMVKNETFCAAT HCCCCCCCCCEEEEC	41.97	UniProtKB CARBOHYD
1315	Phosphorylation	GCANQFSSTAPVLLQ CCCCCCCCCCCEEEE	29.85	28985074
1323	Phosphorylation	TAPVLLQYSHDAGMS CCCEEEEEECCCCCC	14.14	28985074
1330	Phosphorylation	YSHDAGMSWFLVKEG EECCCCCCEEEEECC	17.48	28985074
1351	Phosphorylation	GKGCEGNSRELSEPT CCCCCCCCCCCCCCC	37.68	-
1355	Phosphorylation	EGNSRELSEPTMYHT CCCCCCCCCCCEEEC	36.46	-
1466	Phosphorylation	SPLWYKITGAQVGTG CCCCCCCCCCEEECC	23.47	22210691
1472	Phosphorylation	ITGAQVGTGCGTLND CCCCEEECCCEECCC	30.37	22210691
1476	Phosphorylation	QVGTGCGTLNDGKSL EEECCCEECCCCCEE	26.85	22210691
1520	Phosphorylation	GSKTSGITCIKPRTR CCCCCCEEEECCCCC	16.23	22798277
1599	N-linked_Glycosylation	DDVLIGMNDSSQTGF EEEEECCCCCCCCCC	40.58	UniProtKB CARBOHYD
1749	N-linked_Glycosylation	RFRWIQANYTVGADS CEEEEECCCEECCCC	19.34	UniProtKB CARBOHYD
1802	Phosphorylation	VPVVPLPSILKDDFN EEEEECCHHHCCCCC	48.51	24719451
1873	Phosphorylation	LRFIAKSTPERSHSI EEHHHCCCCCCCCEE	28.58	28555341
1915	Phosphorylation	FINVPLPYTAQTNAT EEECCCCCCCCCCCC	23.53	-
1916	Phosphorylation	INVPLPYTAQTNATR EECCCCCCCCCCCCE	15.45	-
1919	Phosphorylation	PLPYTAQTNATRFRL CCCCCCCCCCCEEEE	25.10	-
1920	N-linked_Glycosylation	LPYTAQTNATRFRLW CCCCCCCCCCEEEEE	27.51	19159218
2144	N-linked_Glycosylation	NGQGSCINGTKCICD CCCCCCCCCCEEEEC	57.31	UniProtKB CARBOHYD
2154	Phosphorylation	KCICDPGYSGPTCKI EEEECCCCCCCCCEE	18.82	-
2155	Phosphorylation	CICDPGYSGPTCKIS EEECCCCCCCCCEEE	44.18	-
2268	N-linked_Glycosylation	LQEFLFSNSSNVGRY HHHHHCCCCCCCCEE	41.97	UniProtKB CARBOHYD
2316	N-linked_Glycosylation	DQILIGGNISGNTVL EEEEECCCCCCCCCC	21.75	UniProtKB CARBOHYD
2342	O-linked_Glycosylation	WLLHPGGTKMPVCGS EEECCCCCCCCCCCC	30.04	OGP
2424	Phosphorylation	TNVECSRYHLQRILV CCCCCHHHHHHHHHE	7.21	23836654
2432	Phosphorylation	HLQRILVSDTFNKWT HHHHHHEECCCCCEE	27.73	23403867
2434	Phosphorylation	QRILVSDTFNKWTRI HHHHEECCCCCEEEE	22.92	23403867
2439	Phosphorylation	SDTFNKWTRITLPLP ECCCCCEEEEECCCC	17.50	23836654
2442	Phosphorylation	FNKWTRITLPLPPYT CCCEEEEECCCCCCC	21.02	25690035
2568	N-linked_Glycosylation	LLVTVDLNLTNAEFI EEEEEECCCCCHHHH	40.11	UniProtKB CARBOHYD
2675	O-linked_Glycosylation	TVMLDTFSSAPVPQH EEEEECCCCCCCCCC	27.90	OGP
2676	O-linked_Glycosylation	VMLDTFSSAPVPQHE EEEECCCCCCCCCCC	32.19	OGP
2821	Phosphorylation	KGWKRITYPLPESLV CCCCEEEEECCHHHC	10.62	-
2840	Phosphorylation	RFRFYQKYSDMQWAI EEEEEHHHCCCEEEE	8.38	30576142
2851	Phosphorylation	QWAIDNFYLGPGCLD EEEEEEEEECCCHHH	19.60	30576142
2932	Phosphorylation	TALYFGGSTVRQAVT EEEEECCHHHHHHHH	24.90	25332170
2961	N-linked_Glycosylation	GRIGSENNMTSCHRP HCCCCCCCCCCCCCC	30.93	UniProtKB CARBOHYD
3015	N-linked_Glycosylation	LPEDALTNTTRLRWW CCHHHCCCCCCCCCC	40.06	19159218
3072	N-linked_Glycosylation	EGTSHEENWSFYPNA CCCCHHHCCCCCCCC	36.39	UniProtKB CARBOHYD
3108	Phosphorylation	DKTHNALSSRELIIQ CCCCCCCCCCEEEEC	25.57	-
3118	Phosphorylation	ELIIQPGYMMQFKIV EEEECCCCEEEEEEE	8.97	-
3123	Acetylation	PGYMMQFKIVVGCEA CCCEEEEEEEEEEEE	20.07	7704215
3166	Phosphorylation	CLPSSSNSIGCSPFQ ECCCCCCCCCCCCCC	23.47	28985074
3184	N-linked_Glycosylation	ATIYNSVNSSSWKRI EEEEECCCCCCCEEE	35.67	UniProtKB CARBOHYD
3186	Phosphorylation	IYNSVNSSSWKRITI EEECCCCCCCEEEEE	34.71	28985074
3319	Phosphorylation	CQIRQAATKPLDLTR CCCCCCCCCCCCCCH	35.89	-
3411	N-linked_Glycosylation	RWWQPRHNGTGHDQW EEECCCCCCCCCCCC	51.50	UniProtKB CARBOHYD
3435	Phosphorylation	VSTRKQNYMMNFSRQ EECCCCCCCCCHHHH	8.68	27251275
3438	N-linked_Glycosylation	RKQNYMMNFSRQHGL CCCCCCCCHHHHHHH	18.40	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RELN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RELN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RELN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP8_HUMAN	LRP8	physical	12899622
VLDLR_HUMAN	VLDLR	physical	12899622
LRP8_HUMAN	LRP8	physical	12670700
VLDLR_HUMAN	VLDLR	physical	12670700
VLDLR_HUMAN	VLDLR	physical	10571241
RELN_HUMAN	RELN	physical	12135781

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 257320: Lissencephaly 2 (LIS2)
• 616436: Epilepsy, familial temporal lobe, 7 (ETL7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-305; ASN-1920 ANDASN-3015, AND MASS SPECTROMETRY.
PubMed: 19159218