REG1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REG1A_HUMAN
• UniProt AC: P05451
• Protein Name: Lithostathine-1-alpha
• Gene Name: REG1A
• Organism: Homo sapiens (Human).
• Sequence Length: 166
• Subcellular Localization: Secreted.
• Protein Description: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration..
• Protein Sequence: MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVSYKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Pyrrolidone_carboxylic_acid	FLSQSQGQEAQTELP HHHHHCCHHHHHCCC	34.90	-
23	Pyrrolidone_carboxylic_acid	FLSQSQGQEAQTELP HHHHHCCHHHHHCCC	34.90	2493268
23	Pyrrolidone_carboxylic_acid	FLSQSQGQEAQTELP HHHHHCCHHHHHCCC	34.90	2493268
27	O-linked_Glycosylation	SQGQEAQTELPQARI HCCHHHHHCCCCCEE	46.68	UniProtKB CARBOHYD
27	O-linked_Glycosylation	SQGQEAQTELPQARI HCCHHHHHCCCCCEE	46.68	2493268
43	Phosphorylation	CPEGTNAYRSYCYYF CCCCCCCCHHEEEEE	11.36	-
45	Phosphorylation	EGTNAYRSYCYYFNE CCCCCCHHEEEEEEC	13.59	28387310
49	Phosphorylation	AYRSYCYYFNEDRET CCHHEEEEEECCCCE	9.07	28387310
86	Phosphorylation	AEGAFVASLIKESGT CCCHHHHHHHHHHCC	25.89	24719451
91	Phosphorylation	VASLIKESGTDDFNV HHHHHHHHCCCCEEE	41.83	22210691
121	Phosphorylation	SSGSLVSYKSWGIGA CCCCEEEEEECCCCC	11.10	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REG1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REG1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REG1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RFWD2_HUMAN	RFWD2	physical	23269672

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.