dbPTM

RBM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RBM3_MOUSE
UniProt AC	O89086
Protein Name	RNA-binding protein 3
Gene Name	Rbm3
Organism	Mus musculus (Mouse).
Sequence Length	153
Subcellular Localization	Nucleus. Cytoplasm. Cell projection, dendrite. Localizes in mRNA granules in dentrites..
Protein Description	Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation..
Protein Sequence	MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASDAMRAMNGESLDGRQIRVDHAGKSARGSRGGAFGGRGRSYSRGGGDQGYGSGRYDSRPGGYGYGYGRSRDYSGSQGGYDRYSGGNYRDNYDN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Methylation	DRETQRSRGFGFITF CCCCCHHCCEEEEEE	46.80	24129315
53	Phosphorylation	SRGFGFITFTNPEHA HCCEEEEEECCHHHH	23.34	18779572
55	Phosphorylation	GFGFITFTNPEHASD CEEEEEECCHHHHHH	41.01	18779572
61	Phosphorylation	FTNPEHASDAMRAMN ECCHHHHHHHHHHHC	28.01	18779572
71	Phosphorylation	MRAMNGESLDGRQIR HHHHCCCCCCCCEEE	32.91	25266776
87	Methylation	DHAGKSARGSRGGAF ECCCCCCCCCCCCCC	51.19	18960567
87	Dimethylation	DHAGKSARGSRGGAF ECCCCCCCCCCCCCC	51.19	-
90	Methylation	GKSARGSRGGAFGGR CCCCCCCCCCCCCCC	50.84	12018999
90	Dimethylation	GKSARGSRGGAFGGR CCCCCCCCCCCCCCC	50.84	-
97	Methylation	RGGAFGGRGRSYSRG CCCCCCCCCCCCCCC	37.42	12019009
97	Dimethylation	RGGAFGGRGRSYSRG CCCCCCCCCCCCCCC	37.42	-
99	Methylation	GAFGGRGRSYSRGGG CCCCCCCCCCCCCCC	30.94	12019019
99	Dimethylation	GAFGGRGRSYSRGGG CCCCCCCCCCCCCCC	30.94	-
100	Phosphorylation	AFGGRGRSYSRGGGD CCCCCCCCCCCCCCC	30.22	26643407
101	Phosphorylation	FGGRGRSYSRGGGDQ CCCCCCCCCCCCCCC	10.88	23970565
102	Phosphorylation	GGRGRSYSRGGGDQG CCCCCCCCCCCCCCC	26.20	26643407
103	Methylation	GRGRSYSRGGGDQGY CCCCCCCCCCCCCCC	39.27	24129315
103	Asymmetric dimethylarginine	GRGRSYSRGGGDQGY CCCCCCCCCCCCCCC	39.27	-
115	Phosphorylation	QGYGSGRYDSRPGGY CCCCCCCCCCCCCCC	23.07	22499769
117	Phosphorylation	YGSGRYDSRPGGYGY CCCCCCCCCCCCCCC	31.29	22499769
118	Methylation	GSGRYDSRPGGYGYG CCCCCCCCCCCCCCC	30.87	24129315
122	Phosphorylation	YDSRPGGYGYGYGRS CCCCCCCCCCCCCCC	17.06	22499769
124	Phosphorylation	SRPGGYGYGYGRSRD CCCCCCCCCCCCCCC	9.93	22499769
126	Phosphorylation	PGGYGYGYGRSRDYS CCCCCCCCCCCCCCC	10.81	22499769
128	Methylation	GYGYGYGRSRDYSGS CCCCCCCCCCCCCCC	21.75	24129315
129	Phosphorylation	YGYGYGRSRDYSGSQ CCCCCCCCCCCCCCC	25.74	27087446
130	Methylation	GYGYGRSRDYSGSQG CCCCCCCCCCCCCCC	45.59	18966541
132	Phosphorylation	GYGRSRDYSGSQGGY CCCCCCCCCCCCCCC	17.51	24759943
133	Phosphorylation	YGRSRDYSGSQGGYD CCCCCCCCCCCCCCC	35.94	25521595
135	Methylation	RSRDYSGSQGGYDRY CCCCCCCCCCCCCCC	21.51	-
135	Phosphorylation	RSRDYSGSQGGYDRY CCCCCCCCCCCCCCC	21.51	27087446
139	Phosphorylation	YSGSQGGYDRYSGGN CCCCCCCCCCCCCCC	12.22	25521595
141	Methylation	GSQGGYDRYSGGNYR CCCCCCCCCCCCCCC	21.02	58859233
142	Phosphorylation	SQGGYDRYSGGNYRD CCCCCCCCCCCCCCC	14.58	22499769
143	Phosphorylation	QGGYDRYSGGNYRDN CCCCCCCCCCCCCCC	40.91	25521595
147	Phosphorylation	DRYSGGNYRDNYDN- CCCCCCCCCCCCCC-	23.71	22499769
151	Phosphorylation	GGNYRDNYDN----- CCCCCCCCCC-----	22.58	22499769

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RBM3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
103	R	Methylation		24129315
Arg-103 is dimethylated, probably to asymmetric dimethylarginine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RBM3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RL4_MOUSE	Rpl4	physical	15684048

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RBM3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND MASSSPECTROMETRY.	19367708 [Abstract]

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