RAC3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAC3_ARATH
• UniProt AC: Q38912
• Protein Name: Rac-like GTP-binding protein ARAC3
• Gene Name: ARAC3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 198
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Associated with the membrane when activated.
• Protein Description: Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation. May be involved in cell polarity control during the actin-dependent tip growth of root hairs. [PubMed: 11387211 SPK1-dependent activation is required for auxin-mediated inhibition of PIN2 internalization during gravitropic responses]
• Protein Sequence: MSASRFIKCVTVGDGAVGKTCLLISYTSNTFPTDYVPTVFDNFSANVIVDGNTINLGLWDTAGQEDYNRLRPLSYRGADVFLLAFSLVSKASYENVSKKWVPELRHYAPGVPIILVGTKLDLRDDKQFFAEHPGAVPISTAQGEELKKLIGAPAYIECSAKTQQNVKAVFDAAIKVVLQPPKNKKKKKRKSQKGCSIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	S-palmitoylation	DGAVGKTCLLISYTS CCCCCCEEEEEEEEC	3.11	20451389
158	S-palmitoylation	GAPAYIECSAKTQQN CCCEEEECCHHCHHH	3.30	-
158	S-palmitoylation	GAPAYIECSAKTQQN CCCEEEECCHHCHHH	3.30	20451389
195	Geranylgeranylation	KRKSQKGCSIL---- CCCCCCCCCCC----	2.70	17242203
195	Methylation	KRKSQKGCSIL---- CCCCCCCCCCC----	2.70	-
195	S-palmitoylation	KRKSQKGCSIL---- CCCCCCCCCCC----	2.70	28894027
195	Geranylgeranylation	KRKSQKGCSIL---- CCCCCCCCCCC----	2.70	17242203

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAC3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAC3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAC3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDIR_ARATH	SCN1	physical	10798620
RIC1_ARATH	RIC1	physical	19818614
ROGF8_ARATH	ROPGEF8	physical	19070620

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Palmitoylation

"Activation status-coupled transient S acylation determines membranepartitioning of a plant Rho-related GTPase.";
Sorek N., Poraty L., Sternberg H., Bar E., Lewinsohn E., Yalovsky S.;
Mol. Cell. Biol. 27:2144-2154(2007).
Cited for: SUBCELLULAR LOCATION,PALMITOYLATION AT CYS-158, ISOPRENYLATION ATCYS-195, MUTAGENESIS OF CYS-158, AND MASS SPECTROMETRY.
PubMed: 17242203

Prenylation

"Activation status-coupled transient S acylation determines membranepartitioning of a plant Rho-related GTPase.";
Sorek N., Poraty L., Sternberg H., Bar E., Lewinsohn E., Yalovsky S.;
Mol. Cell. Biol. 27:2144-2154(2007).
Cited for: SUBCELLULAR LOCATION,PALMITOYLATION AT CYS-158, ISOPRENYLATION ATCYS-195, MUTAGENESIS OF CYS-158, AND MASS SPECTROMETRY.
PubMed: 17242203