dbPTM

RAB38_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB38_HUMAN
UniProt AC	P57729
Protein Name	Ras-related protein Rab-38
Gene Name	RAB38
Organism	Homo sapiens (Human).
Sequence Length	211
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Melanosome . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane Lipid-anchor Cytoplasmic side . Melanosome membrane . Recruited to phagosomes containing S.aureus or M.tubercu
Protein Description	May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. [PubMed: 21255211 Plays an important role in the control of melanin production and melanosome biogenesis]
Protein Sequence	MQAPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALKVLHWDPETVVRLQLWDIAGQERFGNMTRVYYREAMGAFIVFDVTRPATFEAVAKWKNDLDSKLSLPNGKPVSVVLLANKCDQGKDVLMNNGLKMDQFCKEHGFVGWFETSAKENINIDEASRCLVKHILANECDLMESIEPDVVKPHLTSTKVASCSGCAKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	GDLGVGKTSIIKRYV ECCCCCCHHHHHHHH	21.16	-
24	Phosphorylation	DLGVGKTSIIKRYVH CCCCCCHHHHHHHHH	26.29	24719451
38	Phosphorylation	HQNFSSHYRATIGVD HHHCCHHHHEEECCC	12.14	27642862
113	Phosphorylation	NDLDSKLSLPNGKPV CCCHHCCCCCCCCEE	45.58	-
121	Phosphorylation	LPNGKPVSVVLLANK CCCCCEEEEEEEECC	18.29	-
187	Phosphorylation	NECDLMESIEPDVVK CCCCCHHHCCCCCCC	20.49	29255136
199	Phosphorylation	VVKPHLTSTKVASCS CCCCCCCCCCEECCC	32.37	25002506
200	Phosphorylation	VKPHLTSTKVASCSG CCCCCCCCCEECCCC	25.05	25002506
205	S-palmitoylation	TSTKVASCSGCAKS- CCCCEECCCCCCCC-	2.67	-
206	Phosphorylation	STKVASCSGCAKS-- CCCEECCCCCCCC--	34.12	30631047
208	Geranylgeranylation	KVASCSGCAKS---- CEECCCCCCCC----	2.18	17114793
208	Geranylgeranylation	KVASCSGCAKS---- CEECCCCCCCC----	2.18	17114793

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RAB38_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAB38_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB38_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB38_HUMAN

Related Literatures of Post-Translational Modification