RAB26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB26_HUMAN
• UniProt AC: Q9ULW5
• Protein Name: Ras-related protein Rab-26
• Gene Name: RAB26
• Organism: Homo sapiens (Human).
• Sequence Length: 256
• Subcellular Localization: Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasmic vesicle, secretory vesicle membrane ; Lipid-anchor ; Cytoplasmic side . Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation a
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland..
• Protein Sequence: MSRKKTPKSKGASTPAASTLPTANGARPARSGTALSGPDAPPNGPLQPGRPSLGGGVDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGVKVKLQMWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKASFDNIQAWLTEIHEYAQHDVALMLLGNKVDSAHERVVKREDGEKLAKEYGLPFMETSAKTGLNVDLAFTAIAKELKQRSMKAPSEPRFRLHDYVKREGRGASCCRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	PKSKGASTPAASTLP CCCCCCCCCCHHCCC	19.20	25627689
52	Phosphorylation	PLQPGRPSLGGGVDF CCCCCCCCCCCCCCH	37.98	28348404
120	Phosphorylation	VKLQMWDTAGQERFR EEEEEECCCCHHHHH	19.71	21964256
128	Phosphorylation	AGQERFRSVTHAYYR CCHHHHHHCHHHHHH	28.76	29083192
130	Phosphorylation	QERFRSVTHAYYRDA HHHHHHCHHHHHHHH	11.31	29083192
133	Phosphorylation	FRSVTHAYYRDAHAL HHHCHHHHHHHHCHH	7.45	29083192
134	Phosphorylation	RSVTHAYYRDAHALL HHCHHHHHHHHCHHH	11.64	29083192
144	Phosphorylation	AHALLLLYDVTNKAS HCHHHHHHHCCCCCC	14.34	29083192
147	Phosphorylation	LLLLYDVTNKASFDN HHHHHHCCCCCCHHH	28.27	29083192
199	Phosphorylation	GEKLAKEYGLPFMET HHHHHHHHCCCCCCC	24.21	23403867
206	Phosphorylation	YGLPFMETSAKTGLN HCCCCCCCCCCCCCC	23.38	23403867
229	Phosphorylation	AKELKQRSMKAPSEP HHHHHHHHCCCCCCC	23.34	-
253	Geranylgeranylation	REGRGASCCRP---- CCCCCCCCCCC----	1.95	-
254	Geranylgeranylation	EGRGASCCRP----- CCCCCCCCCC-----	7.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.