PX11A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PX11A_HUMAN
• UniProt AC: O75192
• Protein Name: Peroxisomal membrane protein 11A
• Gene Name: PEX11A
• Organism: Homo sapiens (Human).
• Sequence Length: 247
• Subcellular Localization: Peroxisome membrane ; Multi-pass membrane protein .
• Protein Description: May be involved in peroxisomal proliferation and may regulate peroxisomes division. [PubMed: 9792670 May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity Promotes membrane protrusion and elongation on the peroxisomal surface]
• Protein Sequence: MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRKWFRLGNVVHAIQATEQSIHATDLVPRLCLTLANLNRVIYFICDTILWVRSVGLTSGINKEKWRTRAAHHYYYSLLLSLVRDLYEISLQMKRVTCDRAKKEKSASQDPLWFSVAEEETEWLQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNPGIIGLGGLVSSIAGMITVAYPQMKLKTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	RLFRATQYTCMLLRY HHHHHHHHHHHHHHH	9.50	-
47	Ubiquitination	KVVMKLKKLESSVST HHHHHHHHHHHHHHC	68.85	-
50	Phosphorylation	MKLKKLESSVSTGRK HHHHHHHHHHHCCCH	46.61	30177828
51	Phosphorylation	KLKKLESSVSTGRKW HHHHHHHHHHCCCHH	15.65	30177828
53	Phosphorylation	KKLESSVSTGRKWFR HHHHHHHHCCCHHHH	27.39	30177828
54	Phosphorylation	KLESSVSTGRKWFRL HHHHHHHCCCHHHHH	38.56	30177828
116	Acetylation	GLTSGINKEKWRTRA CCCCCCCHHHHHHHH	59.77	26051181
118	Acetylation	TSGINKEKWRTRAAH CCCCCHHHHHHHHHH	43.51	19818997
127	Phosphorylation	RTRAAHHYYYSLLLS HHHHHHHHHHHHHHH	8.33	-
128	Phosphorylation	TRAAHHYYYSLLLSL HHHHHHHHHHHHHHH	5.13	-
129	Phosphorylation	RAAHHYYYSLLLSLV HHHHHHHHHHHHHHH	5.91	-
134	Phosphorylation	YYYSLLLSLVRDLYE HHHHHHHHHHHHHHH	25.45	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PX11A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PX11A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PX11A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM1L_HUMAN	DNM1L	genetic	20826455
FIS1_HUMAN	FIS1	genetic	20826455
PX11A_HUMAN	PEX11A	physical	20826455
FIS1_HUMAN	FIS1	physical	20826455
SUFU_HUMAN	SUFU	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.