PTTG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTTG2_HUMAN
• UniProt AC: Q9NZH5
• Protein Name: Securin-2
• Gene Name: PTTG2
• Organism: Homo sapiens (Human).
• Sequence Length: 202
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Sequence: MATLIYVDKEIGEPGTRVAAKDVLKLESRPSIKALDGISQVLTRRFGKTYDAPSALPKATRKALGTVNRATEKSVKTNGPRKQKQPSFSAKKMTEKTVKTKSSVPASDDAYPEIEKFFPFNLLDFESFDLPEERQIAHLPLSGVPLMILDEEGELEKLFQLGPPSPVKMPSPPWECNLLQSPSSILSTLDVELPAVCYDIDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATLIYVDKE -----CCEEEEECCC	16.64	25348772
16	Phosphorylation	KEIGEPGTRVAAKDV CCCCCCCCCEEHHHH	32.46	25348772
31	Phosphorylation	LKLESRPSIKALDGI HHHCCCCCHHHHHHH	35.29	-
54	Phosphorylation	GKTYDAPSALPKATR CCCCCCCCCCCHHHH	44.13	17192257
66	Phosphorylation	ATRKALGTVNRATEK HHHHHHHCCHHHHHH	18.56	-
87	Phosphorylation	PRKQKQPSFSAKKMT CCCCCCCCCCCCCCC	29.37	21712546
89	Phosphorylation	KQKQPSFSAKKMTEK CCCCCCCCCCCCCCC	43.44	21815630
107	Phosphorylation	TKSSVPASDDAYPEI CCCCCCCCCCCCHHH	29.92	28842319
111	Phosphorylation	VPASDDAYPEIEKFF CCCCCCCCHHHHHHC	14.37	29978859
165	Phosphorylation	LFQLGPPSPVKMPSP HHCCCCCCCCCCCCC	45.52	19664994
165 (in isoform 2)	Phosphorylation	-	45.52	25849741
171	Phosphorylation	PSPVKMPSPPWECNL CCCCCCCCCCCCCCC	39.84	26074081
184	Phosphorylation	NLLQSPSSILSTLDV CCCCCHHHHHHHCCC	30.82	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
165	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTTG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTTG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.
PubMed: 18691976