PTPRT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPRT_HUMAN
• UniProt AC: O14522
• Protein Name: Receptor-type tyrosine-protein phosphatase T
• Gene Name: PTPRT
• Organism: Homo sapiens (Human).
• Sequence Length: 1441
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: May be involved in both signal transduction and cellular adhesion in the CNS..
• Protein Sequence: MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	N-linked_Glycosylation	TGSFMMVNSSGRASG CCCEEEECCCCCCCC	16.74	UniProtKB CARBOHYD
98	N-linked_Glycosylation	LLPTLKENDTHCIDF EECCCCCCCCEEEEE	58.87	UniProtKB CARBOHYD
100	Phosphorylation	PTLKENDTHCIDFHY CCCCCCCCEEEEEEE	30.17	28842319
107	Phosphorylation	THCIDFHYYFSSRDR CEEEEEEEEEECCCC	13.24	24260401
108	Phosphorylation	HCIDFHYYFSSRDRS EEEEEEEEEECCCCC	6.60	24260401
110	Phosphorylation	IDFHYYFSSRDRSSP EEEEEEEECCCCCCC	14.35	-
111	Phosphorylation	DFHYYFSSRDRSSPG EEEEEEECCCCCCCC	28.44	-
137	N-linked_Glycosylation	PQGNPVWNVSGVVTE CCCCCEEEEEEEEEC	20.50	UniProtKB CARBOHYD
208	N-linked_Glycosylation	VEVNVGQNATFQCIA EEEEECCCCEEEEEE	34.71	UniProtKB CARBOHYD
240	Phosphorylation	RDTALMVTRVVNHRR CCCEEEEEEEECCCC	12.09	-
249	Phosphorylation	VVNHRRFSATVSVAD EECCCCCEEEEEHHH	22.63	-
251	Phosphorylation	NHRRFSATVSVADTA CCCCCEEEEEHHHHH	16.47	-
253	Phosphorylation	RRFSATVSVADTAQR CCCEEEEEHHHHHHH	13.77	-
261	Phosphorylation	VADTAQRSVSKYRCV HHHHHHHHCCCEEEE	20.75	27251275
329	Phosphorylation	LKEVEYRTTTGTWAE EEEEEEEECCCCCEE	28.01	24043423
330	Phosphorylation	KEVEYRTTTGTWAET EEEEEEECCCCCEEE	17.77	24043423
331	Phosphorylation	EVEYRTTTGTWAETH EEEEEECCCCCEEEE	31.81	24043423
333	Phosphorylation	EYRTTTGTWAETHIV EEEECCCCCEEEEEE	21.29	24043423
337	Phosphorylation	TTGTWAETHIVDSPN CCCCCEEEEEEECCC	14.79	24043423
342	Phosphorylation	AETHIVDSPNYKLWH EEEEEEECCCCEEEE	12.26	24043423
345	Phosphorylation	HIVDSPNYKLWHLDP EEEECCCCEEEECCC	15.73	24043423
404	Phosphorylation	DIRARQLTLQWEPFG EEEEEEEEEEEEECE	14.47	-
412	Phosphorylation	LQWEPFGYAVTRCHS EEEEECEEEEEEEEE	9.77	-
415	Phosphorylation	EPFGYAVTRCHSYNL EECEEEEEEEEECEE	21.29	-
421	N-linked_Glycosylation	VTRCHSYNLTVQYQY EEEEEECEEEEEEEE	32.05	UniProtKB CARBOHYD
448	Phosphorylation	IQTSSHYTLRGLRPF HHHCCCHHCCCCCCC	12.45	24719451
510	N-linked_Glycosylation	YIQWKPPNETNGVIT EEEECCCCCCCCEEE	76.80	UniProtKB CARBOHYD
536	Phosphorylation	LDPSADLSSQRGKVF CCCCCCCHHCCCCEE	25.60	-
537	Phosphorylation	DPSADLSSQRGKVFK CCCCCCHHCCCCEEE	31.06	-
547	N-linked_Glycosylation	GKVFKLRNETHHLFV CCEEECCCCCEEEEE	69.79	UniProtKB CARBOHYD
562	Phosphorylation	GLYPGTTYSFTIKAS EECCCCEEEEEEECC	11.13	25332170
563	Phosphorylation	LYPGTTYSFTIKAST ECCCCEEEEEEECCC	17.52	25332170
565	Phosphorylation	PGTTYSFTIKASTAK CCCEEEEEEECCCCC	18.67	25332170
587	Phosphorylation	TRIATKISAPSMPEY EEEEECCCCCCCCCC	35.37	25072903
590	Phosphorylation	ATKISAPSMPEYDTD EECCCCCCCCCCCCC	46.84	25072903
594	Phosphorylation	SAPSMPEYDTDTPLN CCCCCCCCCCCCCCC	20.48	25072903
596	Phosphorylation	PSMPEYDTDTPLNET CCCCCCCCCCCCCCC	40.65	25072903
598	Phosphorylation	MPEYDTDTPLNETDT CCCCCCCCCCCCCCC	31.59	25072903
601	N-linked_Glycosylation	YDTDTPLNETDTTIT CCCCCCCCCCCCEEE	51.86	UniProtKB CARBOHYD
603	Phosphorylation	TDTPLNETDTTITVM CCCCCCCCCCEEEEE	37.26	25072903
605	Phosphorylation	TPLNETDTTITVMLK CCCCCCCCEEEEEEC	27.76	25072903
606	Phosphorylation	PLNETDTTITVMLKP CCCCCCCEEEEEECC	19.91	25072903
608	Phosphorylation	NETDTTITVMLKPAQ CCCCCEEEEEECCCH	9.58	25072903
654	N-linked_Glycosylation	SVPVSYRNASSLDSL CCCCCCCCCCCCHHH	35.62	UniProtKB CARBOHYD
684	N-linked_Glycosylation	QPFTVGDNKTYNGYW CCEECCCCCCCCCCC	32.42	UniProtKB CARBOHYD
696	Phosphorylation	GYWNPPLSPLKSYSI CCCCCCCCCCCEEEE	33.68	24719451
728	Phosphorylation	RLATKGASTQNSNTV EEECCCCCCCCCCCC	38.91	-
744	Phosphorylation	PEKQVDNTVKMAGVI HHHHHCHHHHHHHHH	19.62	-
767	Phosphorylation	ILLGVMLTIKRRRNA HHHHHHHHHHHHCCH	13.32	-
778	Phosphorylation	RRNAYSYSYYLKLAK HCCHHHHHHHHHHHH	11.02	29759185
794 (in isoform 1)	Phosphorylation	-	15.54	30206219
795 (in isoform 1)	Phosphorylation	-	45.45	30206219
796 (in isoform 1)	Phosphorylation	-	35.02	30206219
797 (in isoform 1)	Phosphorylation	-	36.09	30206219
798 (in isoform 1)	Phosphorylation	-	8.83	30206219
799 (in isoform 1)	Phosphorylation	-	14.58	30206219
801 (in isoform 1)	Phosphorylation	-	5.64	30206219
893	Phosphorylation	GYGFKEEYEALPEGQ CCCCHHHHCCCCCCC	13.95	-
918	Phosphorylation	ENRNKNRYGNIISYD CCCCCCCCCCEEEEC	24.74	18083107
924	Phosphorylation	RYGNIISYDHSRVRL CCCCEEEECCCEEEE	13.78	18083107
957	Phosphorylation	GYHRPRHYIATQGPM CCCCCCCEEECCCCC	8.11	26074081
960	Phosphorylation	RPRHYIATQGPMQET CCCCEEECCCCCHHH	25.21	26074081
967	Phosphorylation	TQGPMQETVKDFWRM CCCCCHHHHHHHHHH	18.90	26074081
1008	Phosphorylation	WPDDTEVYGDIKVTL CCCCCEEECEEEEEE	11.66	-
1208	Phosphorylation	RNHDKNRSMDVLPLD CCCCCCCCCCEEECC	28.82	27251275
1227	Phosphorylation	FLISVDGESSNYINA EEEEECCCCCHHHCH	46.67	27251275
1329	Phosphorylation	MARPQDGYRIVQHLQ CCCCCCCHHHHHHHH	12.88	-
1337	Phosphorylation	RIVQHLQYIGWPAYR HHHHHHHHCCCCCCC	14.04	-
1352	Phosphorylation	DTPPSKRSLLKVVRR CCCCCHHHHHHHHHH	41.62	24719451
1427	Phosphorylation	MVETLEQYKFVYEVA CCHHHHHHHHHHHHH	9.30	29759185
1431	Phosphorylation	LEQYKFVYEVALEYL HHHHHHHHHHHHHHH	14.07	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
915	Y	Phosphorylation	Kinase	FYN	P06241	PSP
1030	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPRT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPRT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT2A2_HUMAN	ATP2A2	physical	27880917
KPB1_HUMAN	PHKA1	physical	27880917
KPBB_HUMAN	PHKB	physical	27880917

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.