PTHR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTHR_HUMAN
• UniProt AC: P12272
• Protein Name: Parathyroid hormone-related protein
• Gene Name: PTHLH
• Organism: Homo sapiens (Human).
• Sequence Length: 177
• Subcellular Localization: Cytoplasm. Nucleus. Secreted.
• Protein Description: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.; Osteostatin is a potent inhibitor of osteoclastic bone resorption..
• Protein Sequence: MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RRLVQQWSVAVFLLS HHHHHHHHHHHHHHH	8.89	-
17	Phosphorylation	SVAVFLLSYAVPSCG HHHHHHHHHCCCCCC	17.13	-
31	Phosphorylation	GRSVEGLSRRLKRAV CCCHHHHHHHHHHHH	26.64	-
50	Phosphorylation	LLHDKGKSIQDLRRR HHHCCCCCHHHHHHH	33.86	24825855
85	Phosphorylation	VSPNSKPSPNTKNHP CCCCCCCCCCCCCCC	34.22	-
108	Phosphorylation	GRYLTQETNKVETYK CCEECCCCCCCEECC	30.44	10373465
108	O-linked_Glycosylation	GRYLTQETNKVETYK CCEECCCCCCCEECC	30.44	114083
113	Phosphorylation	QETNKVETYKEQPLK CCCCCCEECCCCCCC	42.77	-
121	Phosphorylation	YKEQPLKTPGKKKKG CCCCCCCCCCCCCCC	44.98	12504010
167	O-linked_Glycosylation	DHLSDTSTTSLELDS CCCCCCCCCEEECCC	23.61	OGP
169	Phosphorylation	LSDTSTTSLELDSRR CCCCCCCEEECCCCC	21.67	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
108	T	Phosphorylation	Kinase	CDK1	P06493	PhosphoELM
121	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTHR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTHR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMB1_HUMAN	KPNB1	physical	12504010
IMB1_HUMAN	KPNB1	physical	11401507
ARRB1_HUMAN	ARRB1	physical	12220636
ELAV1_HUMAN	ELAVL1	physical	19056930

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613382: Brachydactyly E2 (BDE2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.