PTGR1_HUMAN - dbPTM
PTGR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTGR1_HUMAN
UniProt AC Q14914
Protein Name Prostaglandin reductase 1
Gene Name PTGR1
Organism Homo sapiens (Human).
Sequence Length 329
Subcellular Localization Cytoplasm.
Protein Description Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4..
Protein Sequence MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFLTVDPYMRVAAKRLKEGDTMMGQQVAKVVESKNVALPKGTIVLASPGWTTHSISDGKDLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGDNLGKTIVKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MVRTKTWTLKK
----CCCEEEEEEEE		22.7825072903
6Phosphorylation--MVRTKTWTLKKHF
--CCCEEEEEEEECC		24.0625072903
8PhosphorylationMVRTKTWTLKKHFVG
CCCEEEEEEEECCCC		33.6525072903
11AcetylationTKTWTLKKHFVGYPT
EEEEEEEECCCCCCC		45.4427452117
11UbiquitinationTKTWTLKKHFVGYPT
EEEEEEEECCCCCCC		45.4429967540
16PhosphorylationLKKHFVGYPTNSDFE
EEECCCCCCCCCCCE		11.1128152594
18PhosphorylationKHFVGYPTNSDFELK
ECCCCCCCCCCCEEE		38.5828258704
20PhosphorylationFVGYPTNSDFELKTA
CCCCCCCCCCEEEEC		46.2728258704
26PhosphorylationNSDFELKTAELPPLK
CCCCEEEECCCCCCC		37.6824275569
55UbiquitinationPYMRVAAKRLKEGDT
HHHHHHHHHHHCCCC		48.8322817900
58UbiquitinationRVAAKRLKEGDTMMG
HHHHHHHHCCCCCHH		64.7821906983
63SulfoxidationRLKEGDTMMGQQVAK
HHHCCCCCHHHHHHH		3.1930846556
64SulfoxidationLKEGDTMMGQQVAKV
HHCCCCCHHHHHHHH		4.8130846556
70UbiquitinationMMGQQVAKVVESKNV
CHHHHHHHHHHCCCE		48.2121906983
74PhosphorylationQVAKVVESKNVALPK
HHHHHHHCCCEECCC		20.23-
75MalonylationVAKVVESKNVALPKG
HHHHHHCCCEECCCC		41.7726320211
752-HydroxyisobutyrylationVAKVVESKNVALPKG
HHHHHHCCCEECCCC		41.77-
75UbiquitinationVAKVVESKNVALPKG
HHHHHHCCCEECCCC		41.7733845483
81MalonylationSKNVALPKGTIVLAS
CCCEECCCCEEEEEC		70.3226320211
81UbiquitinationSKNVALPKGTIVLAS
CCCEECCCCEEEEEC		70.3222817900
82UbiquitinationKNVALPKGTIVLASP
CCEECCCCEEEEECC		20.8022817900
88PhosphorylationKGTIVLASPGWTTHS
CCEEEEECCCCEEEE		21.5625159151
100AcetylationTHSISDGKDLEKLLT
EEECCCCHHHHHHHH		65.2223954790
100UbiquitinationTHSISDGKDLEKLLT
EEECCCCHHHHHHHH		65.2229967540
107PhosphorylationKDLEKLLTEWPDTIP
HHHHHHHHHCCCCCC		46.5720068231
168UbiquitinationIAKLKGCKVVGAVGS
HHHHCCCEEEEEECC		48.9333845483
1682-HydroxyisobutyrylationIAKLKGCKVVGAVGS
HHHHCCCEEEEEECC		48.93-
178AcetylationGAVGSDEKVAYLQKL
EEECCHHHHHHHHHC		36.84-
1782-HydroxyisobutyrylationGAVGSDEKVAYLQKL
EEECCHHHHHHHHHC		36.84-
178UbiquitinationGAVGSDEKVAYLQKL
EEECCHHHHHHHHHC		36.8421906983
184UbiquitinationEKVAYLQKLGFDVVF
HHHHHHHHCCCEEEE		48.2433845483
2042-HydroxyisobutyrylationESLEETLKKASPDGY
HHHHHHHHHHCCCCC		54.43-
204UbiquitinationESLEETLKKASPDGY
HHHHHHHHHHCCCCC		54.4322817900
205UbiquitinationSLEETLKKASPDGYD
HHHHHHHHHCCCCCC		58.1522817900
230SulfoxidationSNTVIGQMKKFGRIA
EEEHHHHHHHCCEEE		4.2630846556
231AcetylationNTVIGQMKKFGRIAI
EEHHHHHHHCCEEEE		36.7419809781
2312-HydroxyisobutyrylationNTVIGQMKKFGRIAI
EEHHHHHHHCCEEEE		36.74-
232AcetylationTVIGQMKKFGRIAIC
EHHHHHHHCCEEEEE		47.9419809789
262PhosphorylationPPPEIVIYQELRMEA
CCCCEEEEEEEECEE		5.7627259358
273PhosphorylationRMEAFVVYRWQGDAR
ECEEEEEEECCCHHH		10.7920068231
280MethylationYRWQGDARQKALKDL
EECCCHHHHHHHHHH		43.1854557191
285MalonylationDARQKALKDLLKWVL
HHHHHHHHHHHHHHH		51.7126320211
289UbiquitinationKALKDLLKWVLEGKI
HHHHHHHHHHHHCCC		42.4229967540
289AcetylationKALKDLLKWVLEGKI
HHHHHHHHHHHHCCC		42.4223954790
324UbiquitinationLKGDNLGKTIVKA--
HCCCCCCCCCCCC--		37.9433845483
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTGR1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTGR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTGR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VATA_HUMANATP6V1Aphysical
22939629
ADHX_HUMANADH5physical
26344197
ADK_HUMANADKphysical
26344197
AK1A1_HUMANAKR1A1physical
26344197
ASSY_HUMANASS1physical
26344197
COF1_HUMANCFL1physical
26344197
AATC_HUMANGOT1physical
26344197
AATM_HUMANGOT2physical
26344197
HINT1_HUMANHINT1physical
26344197
PRDX6_HUMANPRDX6physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTGR1_HUMAN

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Related Literatures of Post-Translational Modification

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