| UniProt ID | PTGES_HUMAN | |
|---|---|---|
| UniProt AC | O14684 | |
| Protein Name | Prostaglandin E synthase | |
| Gene Name | PTGES | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 152 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).. | |
| Protein Sequence | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MPAHSLVMSSPA ---CCCHHHHCCCCH | 25.43 | 24043423 | |
| 9 | Phosphorylation | PAHSLVMSSPALPAF CCHHHHCCCCHHHHH | 26.20 | 24043423 | |
| 10 | Phosphorylation | AHSLVMSSPALPAFL CHHHHCCCCHHHHHH | 8.97 | 24043423 | |
| 20 | Phosphorylation | LPAFLLCSTLLVIKM HHHHHHHHHHHHHHH | 23.27 | 24043423 | |
| 21 | Phosphorylation | PAFLLCSTLLVIKMY HHHHHHHHHHHHHHH | 24.10 | 24043423 | |
| 42 | Ubiquitination | GQVRLRKKAFANPED CCHHHHHHHHCCHHH | 42.16 | 33845483 | |
| 42 | Malonylation | GQVRLRKKAFANPED CCHHHHHHHHCCHHH | 42.16 | 26320211 | |
| 58 | Phosphorylation | LRHGGPQYCRSDPDV HHHCCCCCCCCCHHH | 7.92 | 29214152 | |
| 61 | Phosphorylation | GGPQYCRSDPDVERC CCCCCCCCCHHHHHH | 50.35 | 28152594 | |
| 120 | Ubiquitination | HTVAYLGKLRAPIRS HHHHHHHHCHHCHHH | 32.00 | 21963094 | |
| 120 | 2-Hydroxyisobutyrylation | HTVAYLGKLRAPIRS HHHHHHHHCHHCHHH | 32.00 | - | |
| 148 | Ubiquitination | ALQILWEAARHL--- HHHHHHHHHHCC--- | 9.75 | 21963094 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTGES_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTGES_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTGES_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PTGES_HUMAN | PTGES | physical | 18682561 | |
| PTGES_HUMAN | PTGES | physical | 20369883 | |
| PTGES_HUMAN | PTGES | physical | 21797823 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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