dbPTM

PTC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PTC2_HUMAN
UniProt AC	Q9Y6C5
Protein Name	Protein patched homolog 2
Gene Name	PTCH2
Organism	Homo sapiens (Human).
Sequence Length	1203
Subcellular Localization	Membrane Multi-pass membrane protein.
Protein Description	May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH)..
Protein Sequence	MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGPATG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTRSPPLRE ------CCCCCCHHH	51.68	-
4	Phosphorylation	----MTRSPPLRELP ----CCCCCCHHHCC	38.00	23532336
14	Phosphorylation	LRELPPSYTPPARTA HHHCCCCCCCCCCCC	29.10	22210691
15	Phosphorylation	RELPPSYTPPARTAA HHCCCCCCCCCCCCC	27.42	-
99	Phosphorylation	RVSQELHYTKEKLGE HHHHHHHCCHHHHCH	31.93	29978859
100	Phosphorylation	VSQELHYTKEKLGEE HHHHHHCCHHHHCHH	23.21	29978859
162	Acetylation	DLNKICYKSGVPLIE CHHHHHHHHCCCEEC	36.00	20167786
179	Acetylation	MIERMIEKLFPCVIL HHHHHHHHHCCCEEE	44.49	20167786
197	Acetylation	DCFWEGAKLQGGSAY HHHCCCCCCCCCCCC	52.80	20167786
370	N-linked_Glycosylation	AQEALPENASQQIHA HHHHCCCCHHHHHHC	42.84	UniProtKB CARBOHYD
705	Phosphorylation	GLSLYGATLVQDGLA HHHHHCCHHHCCCCC	24.09	22210691
775	Phosphorylation	AVLPPPATQAPRTWL HHCCCCCCCCCHHHH	30.91	-
806	Phosphorylation	DWASGRITRHSYRNG CCHHCCCCCCCCCCC	22.44	25278378
809	Phosphorylation	SGRITRHSYRNGSED HCCCCCCCCCCCCCC	23.61	25278378
810	Phosphorylation	GRITRHSYRNGSEDG CCCCCCCCCCCCCCC	11.28	25278378
812	N-linked_Glycosylation	ITRHSYRNGSEDGAL CCCCCCCCCCCCCCH	50.54	UniProtKB CARBOHYD
814	Phosphorylation	RHSYRNGSEDGALAY CCCCCCCCCCCCHHH	35.74	25278378
821	Phosphorylation	SEDGALAYKLLIQTG CCCCCHHHHHHHHCC	11.74	25278378
1152	Phosphorylation	ASSSLPQSFARVTTS CCCCCCHHHCEEEEE	20.95	18452278
1157	Phosphorylation	PQSFARVTTSMTVAI CHHHCEEEEEEEEEE	13.96	18452278
1194	Phosphorylation	ATSSGNLSSRGPGPA CCCCCCCCCCCCCCC	23.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PTC2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PTC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PTC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SMO_HUMAN	SMO	physical	9811851

Drug and Disease Associations

Kegg Disease
H00895	Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
OMIM Disease
155255	Medulloblastoma (MDB)
605462	Basal cell carcinoma (BCC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PTC2_HUMAN

Related Literatures of Post-Translational Modification