PRDX6_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDX6_RAT
• UniProt AC: O35244
• Protein Name: Peroxiredoxin-6
• Gene Name: Prdx6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 224
• Subcellular Localization: Cytoplasm . Lysosome . Also found in lung secretory organelles (lamellar bodies).
• Protein Description: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis..
• Protein Sequence: MPGGLLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHFAWSKDINAYNGAAPTEKLPFPIIDDKDRDLAILLGMLDPAEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTASNPVATPVDWKKGESVMVLPTLPEEEAKQLFPKGVFTKELPSGKKYLRYTPQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	FSHPRDFTPVCTTEL CCCCCCCCCCEEHHH	21.07	29779826
49	Phosphorylation	DFTPVCTTELGRAAK CCCCCEEHHHHHHHH	24.88	25575281
56	Acetylation	TELGRAAKLAPEFAK HHHHHHHHHCHHHHH	44.17	22902405
63	Acetylation	KLAPEFAKRNVKLIA HHCHHHHHCCCEEEE	50.23	22902405
89	Phosphorylation	WSKDINAYNGAAPTE HHCCCCCCCCCCCCC	15.05	-
95	Phosphorylation	AYNGAAPTEKLPFPI CCCCCCCCCCCCCCE	40.81	23984901
97	Acetylation	NGAAPTEKLPFPIID CCCCCCCCCCCCEEC	65.03	22902405
106	Succinylation	PFPIIDDKDRDLAIL CCCEECCCCCHHHHH	51.41	26843850
122	Succinylation	GMLDPAEKDEKGMPV CCCCHHHCCCCCCCC	73.60	26843850
141	Acetylation	VFIFGPDKKLKLSIL EEEECCCCCEEEEEE	64.24	22902405
141	Succinylation	VFIFGPDKKLKLSIL EEEECCCCCEEEEEE	64.24	26843850
177	Phosphorylation	TASNPVATPVDWKKG ECCCCCCCCCCCCCC	24.87	22817900
182	Acetylation	VATPVDWKKGESVMV CCCCCCCCCCCEEEE	46.57	22902405
183	Succinylation	ATPVDWKKGESVMVL CCCCCCCCCCEEEEE	64.75	26843850
204	Acetylation	EAKQLFPKGVFTKEL HHHHHCCCCCEECCC	61.44	22902405
209	Acetylation	FPKGVFTKELPSGKK CCCCCEECCCCCCCE	45.87	22902405
209	Succinylation	FPKGVFTKELPSGKK CCCCCEECCCCCCCE	45.87	-
209	Succinylation	FPKGVFTKELPSGKK CCCCCEECCCCCCCE	45.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
177	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
177	T	Phosphorylation	Kinase	MAPK	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
47	C	Oxidation	Irreversibly inactivated by overoxidation of Cys-47 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.	-
177	T	Phosphorylation	Phosphorylation at Thr-177 by MAP kinases increases the phospholipase activity of the enzyme.	19140803

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDX6_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SFTPA_RAT	Sftpa1	physical	16330552

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.