PPRC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPRC1_HUMAN
• UniProt AC: Q5VV67
• Protein Name: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
• Gene Name: PPRC1
• Organism: Homo sapiens (Human).
• Sequence Length: 1664
• Subcellular Localization: Nucleus . Colocalizes with NRF1..
• Protein Description: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes..
• Protein Sequence: MAARRGRRDGVAPPPSGGPGPDPGGGARGSGWGSRSQAPYGTLGAVSGGEQVLLHEEAGDSGFVSLSRLGPSLRDKDLEMEELMLQDETLLGTMQSYMDASLISLIEDFGSLGESRLSLEDQNEVSLLTALTEILDNADSENLSPFDSIPDSELLVSPREGSSLHKLLTLSRTPPERDLITPVDPLGPSTGSSRGSGVEMSLPDPSWDFSPPSFLETSSPKLPSWRPPRSRPRWGQSPPPQQRSDGEEEEEVASFSGQILAGELDNCVSSIPDFPMHLACPEEEDKATAAEMAVPAAGDESISSLSELVRAMHPYCLPNLTHLASLEDELQEQPDDLTLPEGCVVLEIVGQAATAGDDLEIPVVVRQVSPGPRPVLLDDSLETSSALQLLMPTLESETEAAVPKVTLCSEKEGLSLNSEEKLDSACLLKPREVVEPVVPKEPQNPPANAAPGSQRARKGRKKKSKEQPAACVEGYARRLRSSSRGQSTVGTEVTSQVDNLQKQPQEELQKESGPLQGKGKPRAWARAWAAALENSSPKNLERSAGQSSPAKEGPLDLYPKLADTIQTNPIPTHLSLVDSAQASPMPVDSVEADPTAVGPVLAGPVPVDPGLVDLASTSSELVEPLPAEPVLINPVLADSAAVDPAVVPISDNLPPVDAVPSGPAPVDLALVDPVPNDLTPVDPVLVKSRPTDPRRGAVSSALGGSAPQLLVESESLDPPKTIIPEVKEVVDSLKIESGTSATTHEARPRPLSLSEYRRRRQQRQAETEERSPQPPTGKWPSLPETPTGLADIPCLVIPPAPAKKTALQRSPETPLEICLVPVGPSPASPSPEPPVSKPVASSPTEQVPSQEMPLLARPSPPVQSVSPAVPTPPSMSAALPFPAGGLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCLPPPPTVPLVSGTPGAYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPASIGRAVPQPKMESRGTPAGPPENVLPLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKHKVSALVQSPQMKALACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLPAVHPARLRKLSFLPTPRTQGSEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKECPPPAPADSLAVGNSGGVDIPQEKRPLDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGVTEAKHPAAVRLQEGVHGPSRVHVGSGDHDYCVRSRTPPKKMPALVIPEVGSRWNVKRHQDITIKPVLSLGPAAPPPPCIAASREPLDHRTSSEQADPSAPCLAPSSLLSPEASPCRNDMNTRTPPEPSAKQRSMRCYRKACRSASPSSQGWQGRRGRNSRSVSSGSNRTSEASSSSSSSSSSSRSRSRSLSPPHKRWRRSSCSSSGRSRRCSSSSSSSSSSSSSSSSSSSSRSRSRSPSPRRRSDRRRRYSSYRSHDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11 (in isoform 2)	Phosphorylation	-	9.41	24532841
67	Phosphorylation	DSGFVSLSRLGPSLR CCCCEEHHHCCCCHH	20.25	24719451
72	Phosphorylation	SLSRLGPSLRDKDLE EHHHCCCCHHCCCCC	33.95	26852163
166	Acetylation	REGSSLHKLLTLSRT CCCCCHHHHHHHCCC	50.95	25953088
166	Ubiquitination	REGSSLHKLLTLSRT CCCCCHHHHHHHCCC	50.95	-
169	Phosphorylation	SSLHKLLTLSRTPPE CCHHHHHHHCCCCCC	32.88	28270605
171	Phosphorylation	LHKLLTLSRTPPERD HHHHHHHCCCCCCCC	28.95	25159151
173	Phosphorylation	KLLTLSRTPPERDLI HHHHHCCCCCCCCCC	39.56	25159151
181	Phosphorylation	PPERDLITPVDPLGP CCCCCCCCCCCCCCC	25.26	21815630
189	Phosphorylation	PVDPLGPSTGSSRGS CCCCCCCCCCCCCCC	43.53	23312004
190	Phosphorylation	VDPLGPSTGSSRGSG CCCCCCCCCCCCCCC	44.19	23312004
192	Phosphorylation	PLGPSTGSSRGSGVE CCCCCCCCCCCCCCC	19.56	20068231
193	Phosphorylation	LGPSTGSSRGSGVEM CCCCCCCCCCCCCCC	41.84	23312004
213	Phosphorylation	SWDFSPPSFLETSSP CCCCCCCHHHCCCCC	45.94	28985074
217	Phosphorylation	SPPSFLETSSPKLPS CCCHHHCCCCCCCCC	36.33	28985074
224	Phosphorylation	TSSPKLPSWRPPRSR CCCCCCCCCCCCCCC	46.27	28985074
230	Phosphorylation	PSWRPPRSRPRWGQS CCCCCCCCCCCCCCC	53.03	20068231
237	Phosphorylation	SRPRWGQSPPPQQRS CCCCCCCCCCCCCCC	35.12	30266825
369	Phosphorylation	PVVVRQVSPGPRPVL CEEEEECCCCCCCEE	18.79	26074081
411	Acetylation	KVTLCSEKEGLSLNS EEEECCCCCCCCCCC	40.57	26051181
411	Ubiquitination	KVTLCSEKEGLSLNS EEEECCCCCCCCCCC	40.57	-
415	Phosphorylation	CSEKEGLSLNSEEKL CCCCCCCCCCCHHHC	36.04	25159151
424	Phosphorylation	NSEEKLDSACLLKPR CCHHHCCCCCCCCCH	31.17	27251275
453	Phosphorylation	PANAAPGSQRARKGR CCCCCCCCHHHHCCC	18.55	26434776
481	Phosphorylation	GYARRLRSSSRGQST HHHHHHHHCCCCCCC	36.94	29978859
482	Phosphorylation	YARRLRSSSRGQSTV HHHHHHHCCCCCCCC	20.02	29978859
483	Phosphorylation	ARRLRSSSRGQSTVG HHHHHHCCCCCCCCC	41.50	29978859
487	Phosphorylation	RSSSRGQSTVGTEVT HHCCCCCCCCCCHHH	28.08	29978859
488	Phosphorylation	SSSRGQSTVGTEVTS HCCCCCCCCCCHHHH	18.31	29978859
491	Phosphorylation	RGQSTVGTEVTSQVD CCCCCCCCHHHHHHH	23.97	29978859
518	Acetylation	ESGPLQGKGKPRAWA HHCCCCCCCCHHHHH	51.29	23749302
520	Acetylation	GPLQGKGKPRAWARA CCCCCCCCHHHHHHH	34.51	23749302
535	Phosphorylation	WAAALENSSPKNLER HHHHHHCCCHHHHHH	38.35	30266825
536	Phosphorylation	AAALENSSPKNLERS HHHHHCCCHHHHHHH	52.02	30266825
543	Phosphorylation	SPKNLERSAGQSSPA CHHHHHHHCCCCCCC	27.63	29514088
547	Phosphorylation	LERSAGQSSPAKEGP HHHHCCCCCCCCCCC	37.05	23401153
548	Phosphorylation	ERSAGQSSPAKEGPL HHHCCCCCCCCCCCC	22.46	28464451
691	Phosphorylation	VLVKSRPTDPRRGAV EEECCCCCCCCCCHH	58.48	23403867
700	Phosphorylation	PRRGAVSSALGGSAP CCCCHHHHHHCCCCC	22.40	30576142
713	Phosphorylation	APQLLVESESLDPPK CCEEEEECCCCCCCC	25.63	30576142
721	Phosphorylation	ESLDPPKTIIPEVKE CCCCCCCCCCHHHHH	29.88	30576142
737	Phosphorylation	VDSLKIESGTSATTH HHHCEECCCCCCCCC	51.34	24719451
752	Phosphorylation	EARPRPLSLSEYRRR CCCCCCCCHHHHHHH	32.31	24719451
754	Phosphorylation	RPRPLSLSEYRRRRQ CCCCCCHHHHHHHHH	29.25	24719451
767	Phosphorylation	RQQRQAETEERSPQP HHHHHHHHHHCCCCC	46.27	27794612
771	Phosphorylation	QAETEERSPQPPTGK HHHHHHCCCCCCCCC	31.03	28985074
776	Phosphorylation	ERSPQPPTGKWPSLP HCCCCCCCCCCCCCC	59.06	27794612
785	Phosphorylation	KWPSLPETPTGLADI CCCCCCCCCCCCCCC	24.98	27273156
825	Phosphorylation	CLVPVGPSPASPSPE EEEECCCCCCCCCCC	27.46	26074081
828	Phosphorylation	PVGPSPASPSPEPPV ECCCCCCCCCCCCCC	29.33	26074081
830	Phosphorylation	GPSPASPSPEPPVSK CCCCCCCCCCCCCCC	39.12	26074081
836	Phosphorylation	PSPEPPVSKPVASSP CCCCCCCCCCCCCCC	36.70	26074081
841	Phosphorylation	PVSKPVASSPTEQVP CCCCCCCCCCCCCCC	36.76	25850435
842	Phosphorylation	VSKPVASSPTEQVPS CCCCCCCCCCCCCCC	26.55	25850435
844	Phosphorylation	KPVASSPTEQVPSQE CCCCCCCCCCCCCCC	40.78	26074081
849	Phosphorylation	SPTEQVPSQEMPLLA CCCCCCCCCCCCCCC	39.66	26074081
859	Phosphorylation	MPLLARPSPPVQSVS CCCCCCCCCCCCCCC	35.96	-
891	Phosphorylation	GGLGMPPSLPPPPLQ CCCCCCCCCCCCCCC	47.87	26074081
901	Phosphorylation	PPPLQPPSLPLSMGP CCCCCCCCCCCCCCC	49.67	26074081
905	Phosphorylation	QPPSLPLSMGPVLPD CCCCCCCCCCCCCCC	21.54	26074081
1015	Sumoylation	GRAVPQPKMESRGTP CCCCCCCCCCCCCCC	50.48	-
1015	Sumoylation	GRAVPQPKMESRGTP CCCCCCCCCCCCCCC	50.48	-
1063	Phosphorylation	EVKPVPASPHPKHKV EEEECCCCCCCCCCH	20.05	25159151
1069	Acetylation	ASPHPKHKVSALVQS CCCCCCCCHHHHHCC	43.97	26051181
1076	Phosphorylation	KVSALVQSPQMKALA CHHHHHCCCCHHHHE	15.04	30266825
1101	Sumoylation	EPASERLKPETQETR CCHHHCCCCCCCCCC	47.21	-
1101	Sumoylation	EPASERLKPETQETR CCHHHCCCCCCCCCC	47.21	-
1101	Ubiquitination	EPASERLKPETQETR CCHHHCCCCCCCCCC	47.21	-
1112	Acetylation	QETRPREKPPLPATK CCCCCCCCCCCCCCC	53.89	30591497
1144	Phosphorylation	PARLRKLSFLPTPRT HHHHCCCCCCCCCCC	27.98	23898821
1148	Phosphorylation	RKLSFLPTPRTQGSE CCCCCCCCCCCCCCH	27.78	-
1229	Phosphorylation	LANVAGLTPPATPPH HHHHCCCCCCCCCHH	26.72	27273156
1233	Phosphorylation	AGLTPPATPPHQLWK CCCCCCCCCHHHCHH	43.03	27273156
1246	Phosphorylation	WKPLAAVSLLAKAKS HHHHHHHHHHHHCCC	16.97	-
1253	Phosphorylation	SLLAKAKSPKSTAQE HHHHHCCCCCCCCCC	42.28	20068231
1302	Phosphorylation	DHDYCVRSRTPPKKM CCCEECCCCCCCCCC	21.80	23312004
1304	Phosphorylation	DYCVRSRTPPKKMPA CEECCCCCCCCCCCE	45.23	23312004
1319	Phosphorylation	LVIPEVGSRWNVKRH EEECCCCCCCCCCCC	39.02	20068231
1332	Acetylation	RHQDITIKPVLSLGP CCCCCEEEECEECCC	22.03	26051181
1358	Phosphorylation	REPLDHRTSSEQADP CCCCCCCCCCCCCCC	32.93	29449344
1359	Phosphorylation	EPLDHRTSSEQADPS CCCCCCCCCCCCCCC	31.66	29449344
1360	Phosphorylation	PLDHRTSSEQADPSA CCCCCCCCCCCCCCC	32.87	29449344
1366	Phosphorylation	SSEQADPSAPCLAPS CCCCCCCCCCCCCCH	45.44	29449344
1373	Phosphorylation	SAPCLAPSSLLSPEA CCCCCCCHHHCCCCC	28.19	28348404
1374	Phosphorylation	APCLAPSSLLSPEAS CCCCCCHHHCCCCCC	32.07	28348404
1377	Phosphorylation	LAPSSLLSPEASPCR CCCHHHCCCCCCCCC	26.45	29978859
1381	Phosphorylation	SLLSPEASPCRNDMN HHCCCCCCCCCCCCC	23.91	29978859
1389	Phosphorylation	PCRNDMNTRTPPEPS CCCCCCCCCCCCCCC	29.31	29449344
1391	Phosphorylation	RNDMNTRTPPEPSAK CCCCCCCCCCCCCHH	40.95	28985074
1398	Acetylation	TPPEPSAKQRSMRCY CCCCCCHHHHHHHHH	51.05	25953088
1411	Phosphorylation	CYRKACRSASPSSQG HHHHHHHCCCCCCCC	32.74	25159151
1413	Phosphorylation	RKACRSASPSSQGWQ HHHHHCCCCCCCCCC	26.93	25159151
1415	Phosphorylation	ACRSASPSSQGWQGR HHHCCCCCCCCCCCC	32.57	23663014
1416	Phosphorylation	CRSASPSSQGWQGRR HHCCCCCCCCCCCCC	35.78	30108239
1429	Phosphorylation	RRGRNSRSVSSGSNR CCCCCCCCCCCCCCC	26.60	-
1434	Phosphorylation	SRSVSSGSNRTSEAS CCCCCCCCCCCCCCC	25.70	-
1441	Phosphorylation	SNRTSEASSSSSSSS CCCCCCCCCCCCCCC	27.05	-
1442	Phosphorylation	NRTSEASSSSSSSSS CCCCCCCCCCCCCCC	41.09	-
1443	Phosphorylation	RTSEASSSSSSSSSS CCCCCCCCCCCCCCC	31.57	26552605
1444	Phosphorylation	TSEASSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	26552605
1445	Phosphorylation	SEASSSSSSSSSSSR CCCCCCCCCCCCCCC	35.87	26552605
1446	Phosphorylation	EASSSSSSSSSSSRS CCCCCCCCCCCCCCC	35.87	26552605
1447	Phosphorylation	ASSSSSSSSSSSRSR CCCCCCCCCCCCCCC	35.87	26552605
1448	Phosphorylation	SSSSSSSSSSSRSRS CCCCCCCCCCCCCCC	35.87	26552605
1449	Phosphorylation	SSSSSSSSSSRSRSR CCCCCCCCCCCCCCC	33.99	26552605
1450	Phosphorylation	SSSSSSSSSRSRSRS CCCCCCCCCCCCCCC	31.55	26552605
1451	Phosphorylation	SSSSSSSSRSRSRSL CCCCCCCCCCCCCCC	35.90	26552605
1455	Phosphorylation	SSSSRSRSRSLSPPH CCCCCCCCCCCCCCC	27.71	-
1457	Phosphorylation	SSRSRSRSLSPPHKR CCCCCCCCCCCCCHH	34.15	27732954
1459	Phosphorylation	RSRSRSLSPPHKRWR CCCCCCCCCCCHHHC	37.32	27732954
1476	Phosphorylation	SCSSSGRSRRCSSSS CCCCCCCCCCCCCCC	27.83	-
1480	Phosphorylation	SGRSRRCSSSSSSSS CCCCCCCCCCCCCCC	31.29	-
1481	Phosphorylation	GRSRRCSSSSSSSSS CCCCCCCCCCCCCCC	37.55	-
1482	Phosphorylation	RSRRCSSSSSSSSSS CCCCCCCCCCCCCCC	20.25	-
1483	Phosphorylation	SRRCSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1484	Phosphorylation	RRCSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1485	Phosphorylation	RCSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1486	Phosphorylation	CSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1487	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	21118733
1488	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	21118733
1489	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	21118733
1490	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	21118733
1491	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	26552605
1492	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	26552605
1493	Phosphorylation	SSSSSSSSSSSSSSR CCCCCCCCCCCCCCC	35.87	26552605
1494	Phosphorylation	SSSSSSSSSSSSSRS CCCCCCCCCCCCCCC	35.87	26552605
1495	Phosphorylation	SSSSSSSSSSSSRSR CCCCCCCCCCCCCCC	35.87	26552605
1496	Phosphorylation	SSSSSSSSSSSRSRS CCCCCCCCCCCCCCC	35.87	26552605
1497	Phosphorylation	SSSSSSSSSSRSRSR CCCCCCCCCCCCCCC	33.99	26552605
1498	Phosphorylation	SSSSSSSSSRSRSRS CCCCCCCCCCCCCCC	31.55	26552605
1499	Phosphorylation	SSSSSSSSRSRSRSP CCCCCCCCCCCCCCC	35.90	26552605
1501	Phosphorylation	SSSSSSRSRSRSPSP CCCCCCCCCCCCCCC	36.23	29632367
1503	Phosphorylation	SSSSRSRSRSPSPRR CCCCCCCCCCCCCCC	38.05	29632367
1505	Phosphorylation	SSRSRSRSPSPRRRS CCCCCCCCCCCCCHH	30.86	26657352
1507	Phosphorylation	RSRSRSPSPRRRSDR CCCCCCCCCCCHHHH	32.08	28102081
1512	Phosphorylation	SPSPRRRSDRRRRYS CCCCCCHHHHHHHHH	33.39	24719451
1521 (in isoform 2)	Ubiquitination	-	15.36	21906983
1523 (in isoform 2)	Ubiquitination	-	25.65	21906983
1549	Ubiquitination	RRVVFIGKIPGRMTR CEEEEEECCCCCCCH	40.69	-
1555	Phosphorylation	GKIPGRMTRSELKQR ECCCCCCCHHHHHHH	29.68	23312004
1557	Phosphorylation	IPGRMTRSELKQRFS CCCCCCHHHHHHHHE	37.81	23312004
1603	Ubiquitination	AAIESGHKLRQADEQ HHHHHCCCCCCCCCC	49.22	-
1626	Phosphorylation	RRQFCKRSYSDLDSN CHHHHHCCHHHCCCC	17.93	25159151
1627	Phosphorylation	RQFCKRSYSDLDSNR HHHHHCCHHHCCCCC	15.38	27732954
1628	Phosphorylation	QFCKRSYSDLDSNRE HHHHCCHHHCCCCCC	32.70	28985074
1632	Phosphorylation	RSYSDLDSNREDFDP CCHHHCCCCCCCCCC	45.12	23312004
1643	Ubiquitination	DFDPAPVKSKFDSLD CCCCCCCCHHHHCCC	47.04	21906983
1643 (in isoform 1)	Ubiquitination	-	47.04	21906983
1645	Sumoylation	DPAPVKSKFDSLDFD CCCCCCHHHHCCCHH	47.69	-
1645	Sumoylation	DPAPVKSKFDSLDFD CCCCCCHHHHCCCHH	47.69	-
1645	Ubiquitination	DPAPVKSKFDSLDFD CCCCCCHHHHCCCHH	47.69	21906983
1645 (in isoform 1)	Ubiquitination	-	47.69	21906983
1656	Ubiquitination	LDFDTLLKQAQKNLR CCHHHHHHHHHHHHC	46.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPRC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPRC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPRC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRF1_HUMAN	NRF1	physical	11340167

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.