dbPTM

PP2D1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PP2D1_HUMAN
UniProt AC	A8MPX8
Protein Name	Protein phosphatase 2C-like domain-containing protein 1
Gene Name	PP2D1
Organism	Homo sapiens (Human).
Sequence Length	630
Subcellular Localization
Protein Description
Protein Sequence	MSTNNALRVFWKSREWNMKTSTFDSDEDILLLPKRKRFRKKKSRPVRHTKRHEEEQVYEQGTTLPCSICKHEIDLTGIFLHKKQHVALATLGFQWMGRKKPQPSVIAVQRQFMISKLLSSFMFTEKTLQSINNAFELLWKKQIPAYYKIFDNIDRSVIYSQKICHLLIKGVGICEDRNSTWKADMNDKFTVVSNFGNKPNVCFFGLFDGHHGASAAELTSMELPVLLLHQLSKFDPSYQMTTDEQQIINSFYTVFREEYAAIEDLFSAINKTEAVRCEYEDTHKAFAKAFWRMDRLLGLGRKEVSRVQWSGCSAVTCILEGKPKSPYAHKNWKRKNTHDGLAESSPSQEMPKIISGILHVANTGNVQAVLCRNGKGFCLTKEHTTRNTNERRRILQNGAVISSNEPYGLVEGQVKTTRGLGFHGNLKLKKSIIPAPQTISVPIDDLCQFLIVATNGLWEVLDKEEVTALAMTTFHMYKETYCPIIPNKSPSKGPLLFSTSEPNLTKSQSNIHVLFQYKSVSEVRVSTTNSKENLSDSNYSKYCIYNPENVETFPAETTHRKPCSEKVTDRPTSVNDVATNEKESDTKSFYEGAAEYVSHELVNAALLAGSRDNITVMVIFLNGSEYQLLT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
119	Phosphorylation	FMISKLLSSFMFTEK HHHHHHHHHCCCCHH	31.78	30576142
384	Phosphorylation	FCLTKEHTTRNTNER EEECCCCCCCCHHHH	28.66	24114839
385	Phosphorylation	CLTKEHTTRNTNERR EECCCCCCCCHHHHH	24.67	24114839
489	Phosphorylation	CPIIPNKSPSKGPLL CCCCCCCCCCCCCCE	40.83	27461979
491	Phosphorylation	IIPNKSPSKGPLLFS CCCCCCCCCCCCEEE	58.28	27461979
498	Phosphorylation	SKGPLLFSTSEPNLT CCCCCEEECCCCCCC	30.87	30622161
499	Phosphorylation	KGPLLFSTSEPNLTK CCCCEEECCCCCCCC	29.76	30622161
500	Phosphorylation	GPLLFSTSEPNLTKS CCCEEECCCCCCCCC	50.27	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PP2D1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PP2D1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PP2D1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PP2D1_HUMAN

Related Literatures of Post-Translational Modification