dbPTM

PP2BA_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PP2BA_RAT
UniProt AC	P63329
Protein Name	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Name	Ppp3ca
Organism	Rattus norvegicus (Rat).
Sequence Length	521
Subcellular Localization	Cytoplasm . Cell membrane Peripheral membrane protein . Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (PubMed:111
Protein Description	Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. [PubMed: 1322410]
Protein Sequence	MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNIQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEPKAIDP ------CCCCCCCCC	63.71	-
10	Acetylation	EPKAIDPKLSTTDRV CCCCCCCCCCCCCCE	51.85	22902405
32	Ubiquitination	PSHRLTAKEVFDNDG CCCCCCHHHHCCCCC	49.53	-
32	Acetylation	PSHRLTAKEVFDNDG CCCCCCHHHHCCCCC	49.53	22902405
40	Acetylation	EVFDNDGKPRVDILK HHCCCCCCCHHHHHH	32.30	22902405
47	Acetylation	KPRVDILKAHLMKEG CCHHHHHHHHHHHCC	33.81	22902405
107	Phosphorylation	KLFEVGGSPANTRYL HHHCCCCCCCCCEEE	18.21	25403869
111	Phosphorylation	VGGSPANTRYLFLGD CCCCCCCCEEEECCC	23.85	25403869
224	Nitration	RFKEPPAYGPMCDIL HCCCCCCCCCCCCEE	27.77	-
224	Nitrated tyrosine	RFKEPPAYGPMCDIL HCCCCCCCCCCCCEE	27.77	-
228	S-nitrosocysteine	PPAYGPMCDILWSDP CCCCCCCCCEEECCC	3.11	-
228	S-nitrosylation	PPAYGPMCDILWSDP CCCCCCCCCEEECCC	3.11	16418269
258	Phosphorylation	NTVRGCSYFYSYPAV CCCCCCCHHHCCHHH	15.60	-
260	Phosphorylation	VRGCSYFYSYPAVCD CCCCCHHHCCHHHHH	10.08	-
318	Ubiquitination	YLDVYNNKAAVLKYE EEHHCCCCEEEEEEE	33.80	-
323	Ubiquitination	NNKAAVLKYENNVMN CCCEEEEEEECCEEC	43.87	-
411	Phosphorylation	GKMARVFSVLREESE HHHHHHHHHHHHHCC	19.86	19608982
427	Phosphorylation	VLTLKGLTPTGMLPS EEEECCCCCCCCCCC	27.72	25403869
429	Phosphorylation	TLKGLTPTGMLPSGV EECCCCCCCCCCCCC	29.95	25403869
434	Phosphorylation	TPTGMLPSGVLSGGK CCCCCCCCCCCCCCC	37.26	25403869
438	Phosphorylation	MLPSGVLSGGKQTLQ CCCCCCCCCCCHHHH	42.99	25403869
452 (in isoform 2)	Phosphorylation	-	2.58	27115346
458 (in isoform 2)	Phosphorylation	-	4.16	27115346
459	Ubiquitination	IEADEAIKGFSPQHK HHHHHHHCCCCCCCC	62.03	-
459 (in isoform 2)	Phosphorylation	-	62.03	27115346
462	Phosphorylation	DEAIKGFSPQHKITS HHHHCCCCCCCCCCC	32.11	28432305
469	Phosphorylation	SPQHKITSFEEAKGL CCCCCCCCHHHHCCH	33.85	25403869
492	Phosphorylation	PRRDAMPSDANLNSI CCCCCCCCCCCHHHH	35.95	23984901
498	Phosphorylation	PSDANLNSINKALAS CCCCCHHHHHHHHHH	30.61	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
411	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
411	S	Phosphorylation	Kinase	CAMK2D	Q13557	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PP2BA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PP2BA_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SYNJ1_RAT	Synj1	physical	14704270
DYN1_RAT	Dnm1	physical	14704270

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PP2BA_RAT

Related Literatures of Post-Translational Modification