PP14C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP14C_HUMAN
• UniProt AC: Q8TAE6
• Protein Name: Protein phosphatase 1 regulatory subunit 14C
• Gene Name: PPP1R14C
• Organism: Homo sapiens (Human).
• Sequence Length: 165
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Inhibitor of the PP1 regulatory subunit PPP1CA..
• Protein Sequence: MSVATGSSETAGGASGGGARVFFQSPRGGAGGSPGSSSGSGSSREDSAPVATAAAAGQVQQQQQRRHQQGKVTVKYDRKELRKRLVLEEWIVEQLGQLYGCEEEEMPEVEIDIDDLLDADSDEERASKLQEALVDCYKPTEEFIKELLSRIRGMRKLSPPQKKSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSVATGSSE ------CCCCCCCCC	22.06	22814378
25	Phosphorylation	GARVFFQSPRGGAGG CEEEEEECCCCCCCC	16.06	30266825
27	Methylation	RVFFQSPRGGAGGSP EEEEECCCCCCCCCC	62.52	58858209
33	Phosphorylation	PRGGAGGSPGSSSGS CCCCCCCCCCCCCCC	25.77	23927012
36	Phosphorylation	GAGGSPGSSSGSGSS CCCCCCCCCCCCCCC	25.39	23927012
37	Phosphorylation	AGGSPGSSSGSGSSR CCCCCCCCCCCCCCC	44.63	28450419
38	Phosphorylation	GGSPGSSSGSGSSRE CCCCCCCCCCCCCCC	38.38	28450419
40	Phosphorylation	SPGSSSGSGSSREDS CCCCCCCCCCCCCCC	37.13	23927012
42	Phosphorylation	GSSSGSGSSREDSAP CCCCCCCCCCCCCCC	28.11	28450419
43	Phosphorylation	SSSGSGSSREDSAPV CCCCCCCCCCCCCCH	43.12	28450419
47	Phosphorylation	SGSSREDSAPVATAA CCCCCCCCCCHHHHH	29.71	25394399
52	Phosphorylation	EDSAPVATAAAAGQV CCCCCHHHHHHHHHH	19.64	28450419
73	Phosphorylation	RHQQGKVTVKYDRKE HHHCCCCEEEECHHH	18.11	12747765
75	Acetylation	QQGKVTVKYDRKELR HCCCCEEEECHHHHH	31.87	30589651
75	Methylation	QQGKVTVKYDRKELR HCCCCEEEECHHHHH	31.87	30589651
149	Phosphorylation	EFIKELLSRIRGMRK HHHHHHHHHHCHHHH	37.98	24719451
156	Acetylation	SRIRGMRKLSPPQKK HHHCHHHHCCCCCCC	44.41	12431669
158	Phosphorylation	IRGMRKLSPPQKKSV HCHHHHCCCCCCCCC	37.25	30631047
162	Acetylation	RKLSPPQKKSV---- HHCCCCCCCCC----	53.44	12431681

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
73	T	Phosphorylation	Kinase	ILK	Q13418	PSP
73	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
73	T	Phosphorylation	Kinase	STK24	Q9Y6E0	GPS
73	T	Phosphorylation	Kinase	MST4	Q9P289	PSP
73	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP14C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP14C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS35_HUMAN	VPS35	physical	22939629
UBL7_HUMAN	UBL7	physical	22939629
HMCS1_HUMAN	HMGCS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.