dbPTM

POF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POF1_SCHPO
UniProt AC	P87053
Protein Name	F-box/WD repeat-containing protein pof1
Gene Name	pof1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	605
Subcellular Localization	Nucleus .
Protein Description	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Required for the inactivation of zip1 via ubiquitination..
Protein Sequence	MTTGYESVPTSEPSDNLAPRAELWQRHLLEKKEGDQSISVSAFNISSMHNELSGLSEKSRQRVEAVWAAFSEASCSERKLALQGILNNCSSSLLSFASSTLDSLVRLDFLSLLPVEISFRILSFLDARSLCQAAQVSKHWKELADDDVIWHRMCEQHINRKCEKCGWGLPLLERNTLYAAKASIQKRYERLTKRGVDQAHESSPVKKAKLDDYPTSSNEETISSVKPPSPNSDSKFFLPFKTRPWKEVYAERCRVECNWRHGRCRQVVLSGHSDGVMCLQLVRNILASGSYDATIRLWNLATFQQVALLEGHSSGVTCLQFDQCKLISGSMDKTIRIWNYRTSECISILHGHTDSVLCLTFDSTLLVSGSADCTVKLWHFSGGKRITLRGHTGPVNSVRIIRDRGLVLSGSDDSTIKIWSLETNTCLHTFSAHIGPVQSLALADSRLFSCSLDGTIKQWDIEKKKCVHTLFGHIEGVWEIAADHLRLISGAHDGVVKVWEACECVHTLKNHSEPVTSVALGDCEVVSGSEDGKIYLWLFNNAPNESPVSTQSVPISSLNGQRSNSSVQRALSSVPNYSSSLSNISTRNLNIPPSNANNDDVSIQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
202	Phosphorylation	GVDQAHESSPVKKAK CCCCCCCCCCCCCCC	30.03	24763107
203	Phosphorylation	VDQAHESSPVKKAKL CCCCCCCCCCCCCCC	30.63	21712547
215	Phosphorylation	AKLDDYPTSSNEETI CCCCCCCCCCCCCCH	38.26	29996109
216	Phosphorylation	KLDDYPTSSNEETIS CCCCCCCCCCCCCHH	27.02	21712547
217	Phosphorylation	LDDYPTSSNEETISS CCCCCCCCCCCCHHC	51.22	29996109
229	Phosphorylation	ISSVKPPSPNSDSKF HHCCCCCCCCCCCCC	45.28	28889911
232	Phosphorylation	VKPPSPNSDSKFFLP CCCCCCCCCCCCCCC	46.79	28889911
234	Phosphorylation	PPSPNSDSKFFLPFK CCCCCCCCCCCCCCC	31.05	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of POF1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZIP1_SCHPO	zip1	genetic	15660136
CUL1_SCHPO	cul1	physical	15660136
CUL1_SCHPO	cul1	physical	19748355
SKP1_SCHPO	skp1	physical	19748355
RPN12_SCHPO	rpn12	genetic	15660136
ZIP1_SCHPO	zip1	physical	15660136
CUL1_SCHPO	cul1	physical	23535663
SKP1_SCHPO	skp1	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POF1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229 AND SER-232, ANDMASS SPECTROMETRY.	18257517 [Abstract]