PLCD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCD4_HUMAN
• UniProt AC: Q9BRC7
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
• Gene Name: PLCD4
• Organism: Homo sapiens (Human).
• Sequence Length: 762
• Subcellular Localization: Membrane; Peripheral membrane protein. Nucleus. Cytoplasm . Endoplasmic reticulum. Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
• Protein Description: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation..
• Protein Sequence: MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASLLQDQLT -----CCHHHHHHCC	28.45	24043423
10	Phosphorylation	SLLQDQLTTDQDLLL HHHHHHCCCHHHHHH	23.77	24043423
11	Phosphorylation	LLQDQLTTDQDLLLM HHHHHCCCHHHHHHH	40.01	24043423
56	Phosphorylation	HARQARGSAKPSFSI EEEECCCCCCCCCCH	27.80	-
62	Phosphorylation	GSAKPSFSISDVETI CCCCCCCCHHHHHHH	26.06	28387310
64	Phosphorylation	AKPSFSISDVETIRN CCCCCCHHHHHHHHC	34.11	28387310
128	Phosphorylation	LLVDLVTSMDHQERL HHHHHHHCCCHHHHH	18.09	28842319
457	Phosphorylation	AEPELEESELALESQ CCCCHHHHHHHHHHH	28.65	-
504	Phosphorylation	VIYLKSVSFRSFTHS HHHHHHCCCCCCCCC	23.25	24719451
635	Phosphorylation	TLLIQVISGQQLPKV EEEEEHHCCCCCCCC	31.52	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.