dbPTM

PKL_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKL_ARATH
UniProt AC	Q9S775
Protein Name	CHD3-type chromatin-remodeling factor PICKLE
Gene Name	PKL
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1384
Subcellular Localization	Nucleus .
Protein Description	Chromatin remodeling factor that represses the expression of embryonic trait genes (such as NFYB9/LEC1) upon and after seed germination and thus enables the developmental switch to post-germinative growth. Silences some MADS-box proteins such as PHE1 and PHE2. Plays a role during carpel differentiation. Regulates late processes in cytokinin signaling..
Protein Sequence	MSSLVERLRIRSDRKPVYNLDDSDDDDFVPKKDRTFEQVEAIVRTDAKENACQACGESTNLVSCNTCTYAFHAKCLVPPLKDASVENWRCPECVSPLNEIDKILDCEMRPTKSSEQGSSDAEPKPIFVKQYLVKWKGLSYLHCSWVPEKEFQKAYKSNHRLKTRVNNFHRQMESFNNSEDDFVAIRPEWTTVDRILACREEDGELEYLVKYKELSYDECYWESESDISTFQNEIQRFKDVNSRTRRSKDVDHKRNPRDFQQFDHTPEFLKGLLHPYQLEGLNFLRFSWSKQTHVILADEMGLGKTIQSIALLASLFEENLIPHLVIAPLSTLRNWEREFATWAPQMNVVMYFGTAQARAVIREHEFYLSKDQKKIKKKKSGQISSESKQKRIKFDVLLTSYEMINLDSAVLKPIKWECMIVDEGHRLKNKDSKLFSSLTQYSSNHRILLTGTPLQNNLDELFMLMHFLDAGKFGSLEEFQEEFKDINQEEQISRLHKMLAPHLLRRVKKDVMKDMPPKKELILRVDLSSLQKEYYKAIFTRNYQVLTKKGGAQISLNNIMMELRKVCCHPYMLEGVEPVIHDANEAFKQLLESCGKLQLLDKMMVKLKEQGHRVLIYTQFQHMLDLLEDYCTHKKWQYERIDGKVGGAERQIRIDRFNAKNSNKFCFLLSTRAGGLGINLATADTVIIYDSDWNPHADLQAMARAHRLGQTNKVMIYRLINRGTIEERMMQLTKKKMVLEHLVVGKLKTQNINQEELDDIIRYGSKELFASEDDEAGKSGKIHYDDAAIDKLLDRDLVEAEEVSVDDEEENGFLKAFKVANFEYIDENEAAALEAQRVAAESKSSAGNSDRASYWEELLKDKFELHQAEELNALGKRKRSRKQLVSIEEDDLAGLEDVSSDGDESYEAESTDGEAAGQGVQTGRRPYRRKGRDNLEPTPLMEGEGRSFRVLGFNQSQRAIFVQTLMRYGAGNFDWKEFVPRLKQKTFEEINEYGILFLKHIAEEIDENSPTFSDGVPKEGLRIEDVLVRIALLILVQEKVKFVEDHPGKPVFPSRILERFPGLRSGKIWKEEHDKIMIRAVLKHGYGRWQAIVDDKELGIQELICKELNFPHISLSAAEQAGLQGQNGSGGSNPGAQTNQNPGSVITGNNNASADGAQVNSMFYYRDMQRRLVEFVKKRVLLLEKAMNYEYAEEYYGLGGSSSIPTEEPEAEPKIADTVGVSFIEVDDEMLDGLPKTDPITSEEIMGAAVDNNQARVEIAQHYNQMCKLLDENARESVQAYVNNQPPSTKVNESFRALKSINGNINTILSITSDQSKSHEDDTKPDLNNVEMKDTAEETKPLRGGVVDLNVVEGEENIAEASGSVDVKMEEAKEEEKPKNMVVD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	RSDRKPVYNLDDSDD CCCCCCCCCCCCCCC	20.66	23776212
23	Phosphorylation	PVYNLDDSDDDDFVP CCCCCCCCCCCCCCC	42.48	30291188
114	Phosphorylation	EMRPTKSSEQGSSDA CCCCCCCCCCCCCCC	35.18	23328941
118	Phosphorylation	TKSSEQGSSDAEPKP CCCCCCCCCCCCCCC	25.41	30291188
119	Phosphorylation	KSSEQGSSDAEPKPI CCCCCCCCCCCCCCC	47.89	30291188
771	Phosphorylation	GSKELFASEDDEAGK HHHHHHCCCCCCCCC	33.94	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PKL_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKL_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKL_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
HY5_ARATH	HY5	physical	23314848

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKL_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, AND MASSSPECTROMETRY.	19376835 [Abstract]
"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana."; Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.; J. Proteomics 72:439-451(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, SUBCELLULARLOCATION, AND MASS SPECTROMETRY.	19245862 [Abstract]