dbPTM

PKD2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKD2_SCHPO
UniProt AC	Q09917
Protein Name	TRP-like ion channel pkd2
Gene Name	pkd2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	710
Subcellular Localization	Cell membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein .
Protein Description	Acts as a key signaling component in the regulation of cell shape and cell wall synthesis through interaction with GTPase Rho1..
Protein Sequence	MRLWRSPLLLLVVVVELFSWADALTRFISADSLSTCMTDSQLSASKLYASYFPDNQSVAFDISIQSLVSTNVSIDVDISAYGIEIKKVIDPCDMEISGFCPMQTGNIALSGSHTLTGEALSILDSIPSIAYTVPDLDAVVTINIYESDTNTQLACVRTTVQNGRSVYHRAVYWVMCMVIGIPLLIFLLISPVLQTPALWEIVETMITLFQFAQIQALYSMMATSLPAIIYSWGRNFMWSMGIIRIGFMQDVFTWYVKSTGGTPSTLVDLGIHANVALAKRGIDLGSLAKRATTTVTTSTSDSITLRGIKRISYMMGIETTNFFATGFSFFIILLFFSLLVAMASRFIVEMVLLASRNQALKKQRIRLYWKSISKGFFYRVIFVGFTQMSVLSMWEIYTRDSSALAFLSMYVIVDMAVLLCYAFVRTIQIIRKTGPYSHPDVLYNLYSDTQHLMRWGFMYVQLDVRFFYFTFPLLLITLVRSMFIGFGQGSPKVQGCAMFGISVVVFALMVILRPYATKHMNTLHIGVALMNLISGSFILVMCQAFYVEELARQVIGIIFFALNAITMLLLILGIFIRTLIVLFRKSGHGTYYRILDDQSEKATSYNKSIKDMSSSDMAFSDPAYSGTTLRSSVDLNTPEYPFSNRNDSDSTFTNNKYVSPWDAIEEASYANLRGNTDVEQPFMESDYTRISENNNNAERRRKPLPNNAFR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
599	Phosphorylation	YRILDDQSEKATSYN EEEECCCCHHHHHCC	48.32	28889911
603	Phosphorylation	DDQSEKATSYNKSIK CCCCHHHHHCCCCCC	42.69	25720772
604	Phosphorylation	DQSEKATSYNKSIKD CCCHHHHHCCCCCCC	31.41	25720772
605	Phosphorylation	QSEKATSYNKSIKDM CCHHHHHCCCCCCCC	23.43	25720772
608	Phosphorylation	KATSYNKSIKDMSSS HHHHCCCCCCCCCCC	31.09	29996109
631	Phosphorylation	YSGTTLRSSVDLNTP CCCCCCCCCCCCCCC	37.51	28889911
632	Phosphorylation	SGTTLRSSVDLNTPE CCCCCCCCCCCCCCC	17.14	28889911
648	Phosphorylation	PFSNRNDSDSTFTNN CCCCCCCCCCCCCCC	36.69	25720772
650	Phosphorylation	SNRNDSDSTFTNNKY CCCCCCCCCCCCCCC	29.40	25720772
651	Phosphorylation	NRNDSDSTFTNNKYV CCCCCCCCCCCCCCC	39.20	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PKD2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKD2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKD2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHO1_SCHPO	rho1	physical	15537393
YKH3_SCHPO	syn1	physical	19543678
BGS1_SCHPO	bgs1	physical	19543678

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKD2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-599 AND SER-632, ANDMASS SPECTROMETRY.	18257517 [Abstract]