PIPE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIPE_DROME
• UniProt AC: Q86BJ3
• Protein Name: Heparan sulfate 2-O-sulfotransferase pipe
• Gene Name: pip
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 514
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein . Wbl is required for its processing into the Golgi.
• Protein Description: Sulfotransferase involved in dorsoventral axis patterning in early embryos. Required for the specific ventral activation of a series of proteases acting in the perivitelline space between the embryonic membrane and the eggshell. Probably acts by mediating the sulfation of some glycoprotein or glycosaminoglycan stably deposited in the egg, whose ventrally localized modification leads to spatially restricted activation of the protease cascade..
• Protein Sequence: MSLNAERSYKMKLRDVENAFKYRRIPYPKRSVELIALLAISCTFFLFMHTNKLNSRLKEMEVKLQPSEFSALGLTGNHISGHDAGKHDDINTLHGTYQYLKSTGQKVGYNVHDRRSSEEQLRTPTAHGHHHDHHSHHHHMHQQEKIDGHKHKASHDKQLAVPDNKHKEDEVHYEDDEDEVEENDDDLANDVGTTDSEGFNFKADLLNNTKYAEVDFVFFNRVPKVGSQSLMELMARLGKINGFTHARNKGSAHETIVMNKQRQNDLIADLLTRPKPHIYSQHIAYINFTRFHLPKPIYINLIRDPIDRIISWHYYIRAPWYYRDMQAKLGENAIPMPSEEFMNLDLDTCVRNHDPHCTFTQMQIKNPVGDHRRQTLFFCGMNQKLCMPFNSEAAMQKAKRTVETEYAVVGTWEDTNITLSVLEAYIPRYFRNAKVAYYLGKDRLSRVNRNNVTRIVSDETRLILRKNLTNEIEFYEFCKQRLYLQYAALSHGKRFGEDDYLLVPEQQNEYNEDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
207	N-linked_Glycosylation	NFKADLLNNTKYAEV CEEHHHHCCCCEEEE	62.51	-
287	N-linked_Glycosylation	SQHIAYINFTRFHLP ECEEEEEEEEEECCC	21.40	-
416	N-linked_Glycosylation	VGTWEDTNITLSVLE EEEECCCCEEHHHHH	37.25	-
451	N-linked_Glycosylation	LSRVNRNNVTRIVSD HHHCCCCCCEEEECC	33.04	-
467	N-linked_Glycosylation	TRLILRKNLTNEIEF HHHHHHCCCCCHHHH	45.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIPE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIPE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIPE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GD_DROME	gd	genetic	19540119
GD_DROME	gd	genetic	10922064

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.