dbPTM

PIP11_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIP11_ARATH
UniProt AC	P61837
Protein Name	Aquaporin PIP1-1
Gene Name	PIP1-1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	286
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg(2+)..
Protein Sequence	MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPFFEPGELSSWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRALYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHSWDDHWVFWVGPFIGAALAALYHVVVIRAIPFKSRS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGKEEDV -------CCCCHHHC	16.10	16839310
23	Phosphorylation	PERQPIGTSAQSDKD CCCCCCCCCCCCCCC	22.93	30407730
24	Phosphorylation	ERQPIGTSAQSDKDY CCCCCCCCCCCCCCC	21.06	26811356
27	Phosphorylation	PIGTSAQSDKDYKEP CCCCCCCCCCCCCCC	46.47	26811356
284	Phosphorylation	IRAIPFKSRS----- HHCCCCCCCC-----	37.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIP11_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIP11_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIP11_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PIP27_ARATH	PIP3	physical	21798944

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIP11_ARATH

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Methylation of aquaporins in plant plasma membrane."; Santoni V., Verdoucq L., Sommerer N., Vinh J., Pflieger D., Maurel C.; Biochem. J. 400:189-197(2006). Cited for: ACETYLATION AT MET-1, AND MASS SPECTROMETRY.	16839310 [Abstract]