PINK1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PINK1_MOUSE
• UniProt AC: Q99MQ3
• Protein Name: Serine/threonine-protein kinase PINK1, mitochondrial
• Gene Name: Pink1
• Organism: Mus musculus (Mouse).
• Sequence Length: 580
• Subcellular Localization: Mitochondrion outer membrane ; Single-pass membrane protein . Mitochondrion inner membrane ; Single-pass membrane protein . Cytoplasm, cytosol .
• Protein Description: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. [PubMed: 24652937 Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN]
• Protein Sequence: MAVRQALGRGLQLGRALLLRFAPKPGPLFGWGKPGPAAAWGRGERPGQVVSPGAQPRPVGLPLPDRYRFFRQSVAGLAARIQRQFMVRARGGAGPCGRAVFLAFGLGLGLIEEKQAEGRRAASACQEIQAIFTQKTKRVSDPLDTRCWQGFRLEDYLIGQAIGKGCNAAVYEATMPTLPQHLEKAKHLGLIGKGPDVVLKGADGEQAPGTPTFPFAIKMMWNISAGSSSEAILSKMSQELVPASRVALAGEYGAVTYRRSRDGPKQLAPHPNIIRVFRAFTSSVPLLPGALADYPDMLPPHYYPEGLGHGRTLFLVMKNYPCTLRQYLEEQTPSSRLATMMTLQLLEGVDHLVQQGIAHRDLKSDNILVEWDSDGCPWLVISDFGCCLADQHVGLRLPFNSSSVERGGNGSLMAPEVSTAHSGPSAVIDYSKADTWAVGAIAYEIFGLANPFYGQGSAHLESRSYQEAQLPEMPESVPPEARRLVRSLLQREASKRPSARLAANVLHLSLWGEHLLALKNLKLDKMIAWLLQQSAATLLADRLREKSCVETKLQMLFLANLECEALCQAALLLSSWRAAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	Ubiquitination	IQAIFTQKTKRVSDP HHHHHCCCCCCCCCC	53.62	-
227	Phosphorylation	MWNISAGSSSEAILS HHEECCCCCHHHHHH	30.33	-
260	Phosphorylation	GAVTYRRSRDGPKQL CEEEEEECCCCCCCC	26.23	21454597
401	Phosphorylation	GLRLPFNSSSVERGG CEECCCCCCCCCCCC	25.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PINK1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
227	S	Phosphorylation	Autophosphorylation at Ser-227 and Ser-401 is essential for selective recruitment of PRKN to depolarized mitochondria, via PINK1-dependent phosphorylation of ubiquitin and PRKN (By similarity).	25474007
227	S	ubiquitylation	Autophosphorylation at Ser-227 and Ser-401 is essential for selective recruitment of PRKN to depolarized mitochondria, via PINK1-dependent phosphorylation of ubiquitin and PRKN (By similarity).	25474007
401	S	Phosphorylation	Autophosphorylation at Ser-227 and Ser-401 is essential for selective recruitment of PRKN to depolarized mitochondria, via PINK1-dependent phosphorylation of ubiquitin and PRKN (By similarity).	25474007
401	S	ubiquitylation	Autophosphorylation at Ser-227 and Ser-401 is essential for selective recruitment of PRKN to depolarized mitochondria, via PINK1-dependent phosphorylation of ubiquitin and PRKN (By similarity).	25474007

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PINK1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PINK1_MOUSE	Pink1	physical	14607334

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.