dbPTM

PHP4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHP4_SCHPO
UniProt AC	O14318
Protein Name	CCAAT-binding factor complex subunit php4
Gene Name	php4
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	295
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole. Iron starvation induces nuclear accumulation and iron induces relocalization to the cytoplasm, in association with exportin crm1.
Protein Description	Component of the transcription regulatory CCAAT-binding complex. Required for the reprogramming of the cell for iron use. Downregulates pcl1, sdh4, and isa1 underlow-iron conditions..
Protein Sequence	MESSKSPSEVEKSSSASPAPQKPMIRVSKQWVVPPRPKPGRKPALDALGRRKAPIKPRPGPTSALSVEEAKFRVREKQYQDTIGKLQKENNELLEQLEMLQAQLKNSTLDSPKEVEVNSEVVKPDSATTENENRYVNQYNYPVEPPCAKNAVYTEIPIELDPHAFLGDSAKRIRVDSDSKDAKSVPSENGRIRVSMSPQNEINFTPENPAVMEKIRKRGVCNSVEGCLYSGSPKSVKRVRESEETKVYAQLLIDLHKSSKSAPMLKAGPSIAFKLPTMEPNFNDVRPVTSISSSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
15	Phosphorylation	SEVEKSSSASPAPQK HHHHCCCCCCCCCCC	25720772
17	Phosphorylation	VEKSSSASPAPQKPM HHCCCCCCCCCCCCE	25720772
195	Phosphorylation	ENGRIRVSMSPQNEI CCCCEEEEECCCCCC	25720772
197	Phosphorylation	GRIRVSMSPQNEINF CCEEEEECCCCCCCC	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHP4_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHP4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHP4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XPO1_SCHPO	crm1	physical	19502236
GLRX4_SCHPO	grx4	physical	19502236
GLRX4_SCHPO	grx4	physical	22523368
GLRX4_SCHPO	grx4	physical	23695164
GLRX4_SCHPO	grx4	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHP4_SCHPO

Related Literatures of Post-Translational Modification