dbPTM

PHOP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHOP2_HUMAN
UniProt AC	Q8TCD6
Protein Name	Pyridoxal phosphate phosphatase PHOSPHO2
Gene Name	PHOSPHO2
Organism	Homo sapiens (Human).
Sequence Length	241
Subcellular Localization
Protein Description	Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate..
Protein Sequence	MKILLVFDFDNTIIDDNSDTWIVQCAPNKKLPIELRDSYRKGFWTEFMGRVFKYLGDKGVREHEMKRAVTSLPFTPGMVELFNFIRKNKDKFDCIIISDSNSVFIDWVLEAASFHDIFDKVFTNPAAFNSNGHLTVENYHTHSCNRCPKNLCKKVVLIEFVDKQLQQGVNYTQIVYIGDGGNDVCPVTFLKNDDVAMPRKGYTLQKTLSRMSQNLEPMEYSVVVWSSGVDIISHLQFLIKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	HEMKRAVTSLPFTPG HHHHHHHHCCCCCHH	24.46	27282143
71	Phosphorylation	EMKRAVTSLPFTPGM HHHHHHHCCCCCHHH	27.69	27282143
75	Phosphorylation	AVTSLPFTPGMVELF HHHCCCCCHHHHHHH	19.59	27282143
171	Phosphorylation	QLQQGVNYTQIVYIG HHHCCCCEEEEEEEC	9.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHOP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHOP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHOP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TDIF1_HUMAN	DNTTIP1	physical	28514442
SIGL5_HUMAN	SIGLEC5	physical	28514442
CPNE4_HUMAN	CPNE4	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHOP2_HUMAN

Related Literatures of Post-Translational Modification