PEX5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX5_RAT
• UniProt AC: Q2M2R8
• Protein Name: Peroxisomal targeting signal 1 receptor
• Gene Name: Pex5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 640
• Subcellular Localization: Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13) (
• Protein Description: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import..
• Protein Sequence: MAMRELVESECGGANPLMKLATHFTQDKALRQEGLRPPWPPGASAAETVSKPLGVGTEDELVAEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWAEEYLEQSEEKLWLGDPEGTSTTDRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEFLKFVRQIGEGQVSLESAAGSGRAQAEQWAAEFIQQQGTSEAWVDQFTRPGNKLAALQVEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSASYDKGYQFEEENPLRDHPQPFEEGLRRLEEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNRTALMALAVSFTNESLQRQACETLRDWLRYSPAYAHLVAPGEEGASGAGLGPSKRVLGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLPALLTMFGLPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Acetylation	ATHFTQDKALRQEGL HHHHHHHHHHHHCCC	39.23	22902405
114	Phosphorylation	GVADLALSENWAQEF CHHHHHCCCCHHHHH	24.23	-
152	Phosphorylation	AEVTDPLSVSPARWA HHCCCCCCCCHHHHH	26.41	-
154	Phosphorylation	VTDPLSVSPARWAEE CCCCCCCCHHHHHHH	14.96	-
166	Phosphorylation	AEEYLEQSEEKLWLG HHHHHHHCCCCCCCC	38.04	22673903
178	Phosphorylation	WLGDPEGTSTTDRWY CCCCCCCCCCCCCCH	22.65	30181290
179	Phosphorylation	LGDPEGTSTTDRWYD CCCCCCCCCCCCCHH	39.92	30181290
180	Phosphorylation	GDPEGTSTTDRWYDE CCCCCCCCCCCCHHH	32.33	30181290
181	Phosphorylation	DPEGTSTTDRWYDEY CCCCCCCCCCCHHHC	24.27	30181290
228	Phosphorylation	QIGEGQVSLESAAGS HHCCCCEEHHHHCCC	20.66	25575281
231	Phosphorylation	EGQVSLESAAGSGRA CCCEEHHHHCCCCHH	28.81	25575281
235	Phosphorylation	SLESAAGSGRAQAEQ EHHHHCCCCHHHHHH	22.00	25575281
280	Phosphorylation	VEFERAKSAIESDVD HHHHHHHHHHHCCCC	33.23	29779826
284	Phosphorylation	RAKSAIESDVDFWDK HHHHHHHCCCCHHHH	36.50	25575281
311	Phosphorylation	AEAHPWLSDYDDLTS HHHCCCCCCHHHHHH	30.20	22276854
313	Phosphorylation	AHPWLSDYDDLTSAS HCCCCCCHHHHHHCC	14.16	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEX5_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
11	C	ubiquitylation	Monoubiquitination at Cys-11 is required for proper export from peroxisomes and recycling.	18359941

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX5_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP74_RAT	Hspa4	physical	11415446

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.