PERK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PERK1_ARATH
• UniProt AC: Q9LV48
• Protein Name: Proline-rich receptor-like protein kinase PERK1
• Gene Name: PERK1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 652
• Subcellular Localization: Cell membrane ; Single-pass membrane protein .
• Protein Sequence: MSTAPSPGTTPSPSPPSPPTNSTTTTPPPAASSPPPTTTPSSPPPSPSTNSTSPPPSSPLPPSLPPPSPPGSLTPPLPQPSPSAPITPSPPSPTTPSNPRSPPSPNQGPPNTPSGSTPRTPSNTKPSPPSDSSDGLSTGVVVGIAIGGVAILVILTLICLLCKKKRRRRHDDEAAYYVPPPPPSGPKAGGPYGGQQQYWQQQNASRPSDNHVVTSLPPPKPPSPPRKPPPPPPPPAFMSSSGGSDYSDLPVLPPPSPGLVLGFSKSTFTYEELSRATNGFSEANLLGQGGFGYVHKGILPSGKEVAVKQLKAGSGQGEREFQAEVEIISRVHHRHLVSLIGYCMAGVQRLLVYEFVPNNNLEFHLHGKGRPTMEWSTRLKIALGSAKGLSYLHEDCNPKIIHRDIKASNILIDFKFEAKVADFGLAKIASDTNTHVSTRVMGTFGYLAPEYAASGKLTEKSDVFSFGVVLLELITGRRPVDANNVYVDDSLVDWARPLLNRASEEGDFEGLADSKMGNEYDREEMARMVACAAACVRHSARRRPRMSQIVRALEGNVSLSDLNEGMRPGHSNVYSSYGGSTDYDTSQYNDDMIKFRKMALGTQEYGTTGEYSNPTSDYGLYPSGSSSEGQATREMEMGKIKKTGQGYSGPSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	N-linked_Glycosylation	SPPSPPTNSTTTTPP CCCCCCCCCCCCCCC	43.03	-
50	N-linked_Glycosylation	PPPSPSTNSTSPPPS CCCCCCCCCCCCCCC	47.86	-
223	Phosphorylation	LPPPKPPSPPRKPPP CCCCCCCCCCCCCCC	56.94	17317660
269	Phosphorylation	GFSKSTFTYEELSRA EEECCCCCHHHHHHH	30.06	-
301	Phosphorylation	VHKGILPSGKEVAVK EECCCCCCCCEEEEE	60.08	19880383
353	Phosphorylation	GVQRLLVYEFVPNNN HHHEEEEEEECCCCC	12.01	-
408	Phosphorylation	IHRDIKASNILIDFK ECCCHHHCCEEEEEE	21.28	-
434	Phosphorylation	KIASDTNTHVSTRVM EHHHCCCCCCCCEEE	26.25	25561503
437	Phosphorylation	SDTNTHVSTRVMGTF HCCCCCCCCEEEHHC	11.68	23111157
438	Phosphorylation	DTNTHVSTRVMGTFG CCCCCCCCEEEHHCC	26.62	19880383
443	Phosphorylation	VSTRVMGTFGYLAPE CCCEEEHHCCCCCHH	8.87	-
451	Phosphorylation	FGYLAPEYAASGKLT CCCCCHHHHHCCCCC	13.35	24894044
605	Phosphorylation	MALGTQEYGTTGEYS HHHCCCCCCCCCCCC	15.23	30407730
607	Phosphorylation	LGTQEYGTTGEYSNP HCCCCCCCCCCCCCC	30.63	30407730
608	Phosphorylation	GTQEYGTTGEYSNPT CCCCCCCCCCCCCCC	24.53	30407730
611	Phosphorylation	EYGTTGEYSNPTSDY CCCCCCCCCCCCCCC	18.32	30407730
612	Phosphorylation	YGTTGEYSNPTSDYG CCCCCCCCCCCCCCC	31.84	30407730
615	Phosphorylation	TGEYSNPTSDYGLYP CCCCCCCCCCCCCCC	38.18	30407730
616	Phosphorylation	GEYSNPTSDYGLYPS CCCCCCCCCCCCCCC	30.05	30407730
618	Phosphorylation	YSNPTSDYGLYPSGS CCCCCCCCCCCCCCC	14.59	30407730
621	Phosphorylation	PTSDYGLYPSGSSSE CCCCCCCCCCCCCCC	7.32	30407730
623	Phosphorylation	SDYGLYPSGSSSEGQ CCCCCCCCCCCCCCC	37.44	30407730
625	Phosphorylation	YGLYPSGSSSEGQAT CCCCCCCCCCCCCCC	34.72	30407730
626	Phosphorylation	GLYPSGSSSEGQATR CCCCCCCCCCCCCCC	35.61	30407730
627	Phosphorylation	LYPSGSSSEGQATRE CCCCCCCCCCCCCCE	47.66	30407730
632	Phosphorylation	SSSEGQATREMEMGK CCCCCCCCCEEECCC	21.19	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PERK1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PERK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PERK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PERK1_ARATH	PERK1	physical	25969537

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.