PDM2B_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDM2B_DROME
• UniProt AC: Q9VK71
• Protein Name: POU domain protein 2, isoform B
• Gene Name: pdm2 {ECO:0000312|EMBL:AAF53208.2}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 893
• Subcellular Localization: Nucleus .
• Protein Description: DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system..
• Protein Sequence: MPLLLATTLANNSHHQHLSTTATETAAAAATAKAAATAAAAATATMLLTSPTAATHCLAAATSAAGVNVQITGQGVSATLNDDQLQLPANYAANVGHLNGFNPKDNCPPVPPTSERAFEGLLRLPQIQVKQEFMESPPERPSCHPMNHQQAPANSALATSCRGKTILNPWYLRPADGIGYHNYNSNNNNSGSGEINKDVSQQMTSACGGSDGQTCLPVSYFGMETLASVKQRQKSLPDFLIPLHEIMFQQQHHYQQRTMGTLINSLPPGLVGYPPQKTETFKSLTPPKALQHHQNNQNHQIPQNHTGDHSFVRHFHERDRLIREHQLKHQQLRDVEEVLQEQEQDEEQEHETLRKPHVVPSELEHNHHWHGVVCDANGHATRLLHIAPPRAGPTPLPTHQQPPVGEVLPPNSTSFSTIVDPPKEPSIYEQPAPNGRHCRPANKVMRHMSNSPTPPSPLRSLSDCGKSFEEEELELGENCEMPQNLSSKRQARELDSELENEVLDLAPPPKRLAEEQEEEKVASVNPPQPVAFAPEEMHQALQLQLHSYIEMVRQLAPEAFPNPNLATQFLLQNSLQALAQFQALQQMKQQQREDPLPSYSTPLAKSPLRSPSLSPVPRHSKSQQRTPPNSMTANSLGMSSAVMTPNTPSMQQQPQLQQSTPKPTSGLTVASAMAKLEQSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADSTVAKSGGGVFNINTMTSTLSSTPESILGRRRKKRTSIETTVRTTLEKAFLMNCKPTSEEISQLSERLNMDKEVIRVWFCNRRQKEKRINPSLDLDSPTGTPLSSHAFGYPPQALNMSHMQMEGGSGSFCGSSISSGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
467	Phosphorylation	SLSDCGKSFEEEELE CHHHCCCCCCHHHHH	24.15	18327897
606	Phosphorylation	YSTPLAKSPLRSPSL CCCCCCCCCCCCCCC	24.45	22817900
610	Phosphorylation	LAKSPLRSPSLSPVP CCCCCCCCCCCCCCC	26.90	22817900
612	Phosphorylation	KSPLRSPSLSPVPRH CCCCCCCCCCCCCCC	42.60	22817900
614	Phosphorylation	PLRSPSLSPVPRHSK CCCCCCCCCCCCCCC	28.34	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDM2B_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDM2B_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDM2B_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUMB_DROME	numb	genetic	14973280
PDM1_DROME	nub	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.